Results 131 to 140 of about 48,894 (301)

Research on new immunomodulators from marine animals

, 2000
A review on the mechanism of action of Rapamycine and FK-506 and the discovery of bistramide, an immunosuppressive compound from Lissoclinum bistratum, were discussed.
Pusset, Jacques
core  

P79 Inflammatory bowel disease associated colorectal cancer: chemopreventive effects of 5-ASAs, immunomodulators, and biologics

Introduction The incidence and mortality of colorectal cancer (CRC) remains elevated in the inflammatory bowel disease (IBD) population. We aimed to examine the association between biologics, 5-aminosalicylates (5-ASAs), and immunomodulators, with the ...
John Morris, A, Raine, Tim, Kefayat, Amirhosein, Gordon, Morris, Nigam, Gaurav, Lamb, Christopher, Watson, Eleanor, Din, Shahida, Churchhouse, Antonia, Rutter, Matthew, Porter, Ross, Blackwell, Jonathan, East, James, Ford, Alexander   +13 more
core   +1 more source

Dual biologic therapy in inflammatory bowel disease, a retrospective cohort study of vedolizumab and anti‐tumor necrosis factor alpha therapy in children

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Despite advances in pediatric inflammatory bowel disease (PIBD) with biologics, remission rates remain at 47%–60% with loss‐of‐response rates at 60%–68%. Evidence for efficacy of dual biologic therapy (DBT) with anti‐tumor necrosis factor alpha therapy (anti‐TNF‐α)‐ vedolizumab (VDZ) for children refractory to anti‐TNF‐α therapy is ...
Jonathan E. M. O'Donnell, Carlie Bolles, Claire R. Reilly, Manal Morgan, Christopher Burgess, Fariha Balouch, Peter J. Lewindon   +6 more
wiley   +1 more source

Anaemia in patients diagnosed with paediatric‐onset inflammatory bowel disease: A Danish nationwide cohort study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Anaemia impairs daily activities and quality of life in patients with paediatric‐onset inflammatory bowel disease (PIBD). This study aimed to investigate the prevalence of anaemia at PIBD‐diagnosis and the following 5 years. Furthermore, anaemia subtypes and the association between anaemia and disease activity were assessed over ...
Julie Rahbek Norup, Sabine Jansson, Vibeke Wewer, Mikkel Malham   +3 more
wiley   +1 more source

Association of attention‐deficit/hyperactivity disorder and autism with inflammatory bowel disease activity

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To estimate the effect of attention deficit hyperactivity disorder (ADHD) and autism on the disease activity of inflammatory bowel disease (IBD) in pediatric and young patients. Methods Patients diagnosed with IBD between the ages of 6 and 24 years were identified in Danish nationwide registries 1996–2022.
Sabine Jansson, Mads Damsgaard Wewer, Johan Burisch, Matthew P. Fox, Michael E. Benros, Charlotte Ulrikka Rask, Vibeke Wewer, Mikkel Malham   +7 more
wiley   +1 more source

Disability in pediatric inflammatory bowel diseases: A systematic review and a single center experience

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Toward development of a pediatric IBD disability index (PIDI), we aimed to review the literature on disability in pediatric inflammatory bowel disease (PIBD) and to estimate disability rates in a pediatric inception cohort. Methods A systematic review identified studies reporting disability in PIBD and in adult randomized controlled
Reut Rappaport, Ouriel Hannaux, Gili Focht, Liron Marcovitch, Elana Gotkine, Ohad Atia, Esther Orlanski‐Meyer, Raffi Lev‐Tzion, Oren Ledder, Dotan Yogev, Eileen Crowley, Anthony Otley, Anne M. Griffiths, Dan Turner   +13 more
wiley   +1 more source

COVID-19 outcomes in patients with psoriasis and psoriatic arthritis: A prospective cohort study

JAAD International, 2022
Di Yan, MD, Avani M. Kolla, BPhil, Trevor Young, MD, Lauren Fried, MD, Shruthi Shankar, BS, Lauren Rangel, MD, Lu Yin, MD, Rochelle Castillo, MD, Alexa Steuer, MD, Katerina Svigos, MD, Peter Izmirly, MD, Vaish Sekar, MD, Robert Lesser, MD, Gary Solomon, MD, Rebecca B. Blank, MD, Rebecca H. Haberman, MD, Andrea L. Neimann, MD, Jose U. Scher, MD   +17 more
doaj   +1 more source

Proactive therapeutic drug monitoring of infliximab leads to treatment durability in paediatric Crohn's disease: A single‐centre Australian experience

JPGN Reports, EarlyView.
Abstract Objectives To evaluate the durability and predictors of loss of response of infliximab (IFX) over 2 years in paediatric Crohn's disease (CD) utilizing a proactive therapeutic drug monitoring (TDM) strategy. Methods A retrospective, single‐centre cohort study was conducted at The Children's Hospital at Westmead (CHW), Australia, from January ...
Cher Wei Chuah, Jessica Eldredge, Annabel Magoffin, Edward Vincent O'Loughlin, Calvin Joomann Park, Juliana Puppi, Susan Siew, Michael Stormon, Kunal Thacker, Shoma Dutt   +9 more
wiley   +1 more source

Making Every Vaccine Better: Discovery and Development of Vaccine Immunomodulators

This thesis investigates the discovery, development, and application of small molecule immunomodulators for vaccines. Over the past 5 years, modifiers of the immune system were identified via high-throughput screening that can reduce negative ...
Kim, Jeremiah Yoonsung
core   +1 more source

Outcomes of adalimumab biosimilar nonmedical switches in children and young adults with inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Objectives Adalimumab biosimilars are as safe and effective compared to the originator. Adult patients with inflammatory bowel disease (IBD) who switched to a biosimilar have comparable outcomes, but pediatric data are limited. This study evaluates clinical outcomes of children and young adults with IBD following a nonmedical, insurance‐driven
Daniel Himelstein, Megan McNicol, Mahmoud Abdel‐Rasoul, Brendan M. Boyle, Hilary K. Michel, Ross Maltz   +5 more
wiley   +1 more source