Results 151 to 160 of about 48,894 (301)

Immunomodulators as therapeutic strategies for managing multiple sclerosis

, 2011
Immunomodulation and immunosuppression are important strategies for monitoring autoimmune disorders. As imbalances in immune function affect other physiological processes, immunomodulators may have an important role in restoring and maintaining regular ...
Brenu, E. W., Staines, D. R., Tajouri, L., Marshall-Gradisnik, S.   +3 more
core  

Effectiveness and safety of efgartigimod in patients with anti‐NMDAR or anti‐LGI1 encephalitis and its 18F‐DPA714 PET imaging evaluation: A multicenter, single‐arm, prospective, observational real‐world study

Neuroprotection, EarlyView.
Abstract Background Efgartigimod disrupts the recycling of pathogenic IgG autoantibodies and may represent a candidate therapy for autoimmune encephalitis. This real‐world study evaluated the clinical efficacy, safety, and impact of efgartigimod on brain inflammation.
Huanyu Meng, Siqi Tu, Yifan Zhou, Ruinan Shen, Xiaoyu Chen, Zhaozhao Cheng, Limei Wang, Yan Wu, Jie Lu, Shengjun Wang, Yan Xu, Wanhui Lin, Sheng Chen   +12 more
wiley   +1 more source

Colchicine vs pentoxifylline vs minocycline for generalized granuloma annulare: A retrospective cohort study

JAAD International
Jonathan D. Greenzaid, BS, Matthew L. Hrin, MD, Steven R. Feldman, MD, PhD, Lindsay C. Strowd, MD   +3 more
doaj   +1 more source

The Prognostic Role of CD8+ Tumor‐Infiltrating Lymphocyte Density in Head and Neck Mucosal Melanoma

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To explore the prognostic role of CD8+ tumor‐infiltrating lymphocytes (TIL) density in head and neck mucosal melanoma (HNMM) using an automated, quantitative, immunohistochemistry‐based methodology. Study Design Retrospective cohort study. Setting Single‐institution, tertiary care hospital.
Nicholas K. Fung, Douglas Hartman, Diwakar Davar, Eric W. Wang   +3 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

The Audiologic and Otolaryngologic Phenotype in WHIM Syndrome

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis syndrome) is an ultra‐rare primary immunodeficiency disease caused by autosomal dominant hyperfunctional mutations in the chemokine receptor CXCR4. Otolaryngologists are frequently consulted to evaluate WHIM patients because of recurrent acute ear and sinus ...
Christopher K. Zalewski, H. Jeffrey Kim, Carmen C. Brewer, Sophia Martinez, Caroline Rieger, Elena Cho, David H. McDermott, Philip M. Murphy   +7 more
wiley   +1 more source

Spatial pharmacology of anti-cancer immunomodulators: a comprehensive review. [PDF]

Front Pharmacol
Chen S, Tu L, Chen Q.
europepmc   +1 more source

Importance of the delivery route for the tolerability and efficacy of immunomodulatory agents for lung cancer. [PDF]

Sci Rep
Ferreira M, Pitiot A, Parent C, Tartour E, Sizaret D, Heuzé-Vourc'h N, Secher T.   +6 more
europepmc   +1 more source

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Clinical practice guideline for long COVID prevention and treatment. [PDF]

Eur Respir J
Cao B, Soriano JB, Wang Q, Al-Aly Z, Gu X, Wang G, Leo YS, Jin Y, Shi Q, Ohmagari N, Liu E, Paredes R, Lu H, Kim ES, Zhang D, Estill J, Li L, Spruyt K, Yang W, Wang Y, Ran MS, Luo X, Zhang H, Xu J, Zhang R, Zhao J, Zhao J, Evans RA, Jeon J, Peluso MJ, Errett LE, Zhang W, Chalmers JD, Chen Y, Multidisciplinary Working Group on Long COVID Practice Guidelines (MWG-LCPG).   +34 more
europepmc   +1 more source