Results 141 to 150 of about 48,894 (301)

The genetic landscape of congenital diarrheas and very early onset inflammatory bowel disease in the Middle East

JPGN Reports, EarlyView.
Abstract Objectives Monogenic causes of congenital diarrheas and enteropathies (CoDE) and very early onset inflammatory bowel disease (VEOIBD) are mostly recessive and therefore more prevalent in populations with increased consanguinity rates. To assess the genetic basis of these disorders in a likely high‐prevalence population, we established a multi ...
Lily Gillette, Muna Al Safar, Ganeshwaran H. Mochida, Casey Johnson, Stephen Babcock, Klaus Schmitz‐Abe, Michael Field, Jessica Yang, Richelle Bearup, Ahmed Megahed, Mohammed Ezz El Regal Abbas, Tarek Baraket, Sherine Elziny, Ali Sobh, Gulin Eren, Fawaz AlRefaee, Rana Bitar, Mohamed Miqdady, Pankaj B. Agrawal, Scott B. Snapper, Jay R. Thiagarajah, Jodie Ouahed   +21 more
wiley   +1 more source

Macular edema associated with non-infectious uveitis: pathophysiology, etiology, prevalence, impact and management challenges

Clinical Ophthalmology, 2019
Horace Massa,1,* Spyros Y Pipis,2,* Temilade Adewoyin,2 Athanasios Vergados,2 Sudeshna Patra,2 Georgios D Panos2,* 1Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland; 2Eye Treatment Centre, Whipps Cross University Hospital ...
Massa H, Pipis SY, Adewoyin T, Vergados A, Patra S, Panos GD   +5 more
doaj  

The ImproveCareNow Registry: Prediction of different remission rates in pediatric ulcerative colitis

JPGN Reports, EarlyView.
Abstract Objectives Identifying predictors of clinical remission in pediatric ulcerative colitis (UC) will impact the therapeutic approach. We aimed to predict time to first (TFR), corticosteroid‐free (TCSFR, ≥3 months corticosteroid withdrawal), and sustained remission (TSR, ≥6 months).
Jonathan Van Hecke, Gigi Veereman, Koen Huysentruyt, Lucas Wauters, Jeremy Adler, Shehzad Saeed, Elisabeth De Greef, and the ImproveCareNow Pediatric IBD Learning Health System   +7 more
wiley   +1 more source

Acneiform eruption associated with Janus kinase inhibitors in pediatric inflammatory bowel disease: Case series and clinical management guidance

JPGN Reports, EarlyView.
Abstract Janus kinase inhibitors (JAKi) are increasingly used for refractory inflammatory bowel disease (IBD) in pediatric patients but are associated with significant dermatologic adverse effects. Acneiform eruptions have been reported in up to 30% of adults, with a greater incidence suspected in adolescents.
Tina H. Tran, Daniel Park, Regina‐Celeste Ahmad, Malika Goel, Sofia Verstraete, Sabina Ali   +5 more
wiley   +1 more source

Livestock immunomodulators as alternatives to antimicrobials - a roadmap for the fight against drug resistance. [PDF]

BMC Vet Res
Ackerman DS, Morrow A, Smith AL, Entrican G.   +3 more
europepmc   +1 more source

DERMACLEAR: AI‐Powered Insights Into Four Chronic Inflammatory Skin Diseases in Spain

JEADV Clinical Practice, EarlyView.
Using an AI‐enhanced analysis of electronic health records from nearly 50,000 patients, the DERMACLEAR study provides real‐world insights into the prevalence, clinical complexity, comorbidities and treatment patterns of HS, CU, PsO and AD in Spain.
Ana Giménez‐Arnau, Javier Ortiz de Frutos, Raquel Rivera‐Díaz, Lluís Puig, Jaume Notario Rosa, José Luis López‐Estebaranz, Vicente García‐Patos Briones, Ana Martín‐Santiago, José Ignacio Rojo‐Laguna, Elisabet Fernández‐Martínez, Lara Gómez‐Labrador, Esteban Daudén   +11 more
wiley   +1 more source

The impact of malnutrition on clinical outcomes in patients with perianal fistulizing Crohn's disease undergoing seton placement: A retrospective study

Nutrition in Clinical Practice, EarlyView.
Abstract Background Perianal involvement occurs in up to 50% of patients with Crohn's disease (CD). Despite combined management, 10%–20% require fecal diversion or proctectomy. Nutritional status may influence prognosis, but its role in fistulizing perianal disease is unclear.
Bruno Augusto Alves Martins, Oswaldo de Moraes Filho, Tuane Colles, Clíslian Silva, Gabriela de Oliveira Lemos, Dannilo Brito Silveira, Heitor Siqueira Ribeiro, João Batista de Sousa   +7 more
wiley   +1 more source

Immunomodulatory LNP-mRNA therapeutics: The next phase of precision immuno-engineering. [PDF]

Mol Ther Nucleic Acids
Patel K, Egelston C, Scott T.
europepmc   +1 more source

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Neuroprotection, EarlyView.
This manuscript presents a novel therapeutic strategy using mesenchymal stem cells (MSCs) engineered as living drug factories to deliver a P2X7‐blocking nanobody for treatment of ischemic stroke. By combining targeted cellular delivery with sustained local immunomodulation, the approach aims to overcome key limitations of systemic biologic ...
Lucia Fadon‐Padilla, Chengyan Chu, Lorissa McDougall, Yajie Liang, Chinmoy Sarkar, Marta Lipinski, Tim Magnus, Miroslaw Janowski, Piotr Walczak   +8 more
wiley   +1 more source

Age, Rather Than Social Vulnerability, Is Associated With Disparities in Prescription Patterns in Inflammatory Bowel Disease: An Epic Cosmos Study. [PDF]

Gastro Hep Adv
Zuercher H, Potlach T, Sinha M, Baskaran N, Bidani SS, Olson S, Jiao T, Zimmermann EM, Chaudhry NA.   +8 more
europepmc   +1 more source