Results 51 to 60 of about 48,894 (301)
The efficacy of novel therapeutic modalities of isolated ocular vasculitis vs ocular vasculitis as a systemic disease [PDF]
Medicinski Glasnik, 2012 Aim To evaluate the efficacy of new therapeutic modalities withthe observation period of three years on patients with isolated ocular vasculitis in comparison with ocular vasculitis as a systemicdisease.
Filip M. Radotić +5 more
doaj
Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction
Advanced Science, EarlyView.In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng +12 more
wiley +1 more source
Frontiers in Pharmacology, 2021 Background: Validate the Treatment Adherence Measure (TAM) instrument in outpatients with MM concerning construct validity, reliability and the ceiling and floor effects.Methods: This cross-sectional study included patients diagnosed with MM previously ...
Lívia Pena Silveira +9 more
doaj +1 more source
Advanced Science, EarlyView.Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han +11 more
wiley +1 more source
Антибиотики и Химиотерапия, 2020 The study was aimed at possible increase of the therapy efficacy in patients with advanced tuberculosis by including immunomodulators to the treatment schemes.
V. M. Kolomiets +3 more
doaj
Development of prognostic gene signatures based on 54 FABP4-associated immunomodulators.
, 2022 (A) Univariate Cox analysis of the 54 immunomodulators associated with overall survival in TCGA-COAD patients. (B) Multivariate Cox analysis for constructing a 2-immunomodulators prognostic signature. The Hazard radio was shown in the plot.
Ling Xiang (5490848) +7 more
core +1 more source
Advanced Science, EarlyView.Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh +22 more
wiley +1 more source
Immunomodulators in Therapy of Respiratory Infections
Антибиотики и Химиотерапия, 2020 Viral infections provoke dysbalance in the interferon system and inhibition of the cellular and phagocytic responses of the host. Long-term persistence of pathogenic viruses and bacteria induce atopy and could aggravate chronic respiratory diseases.
V. A. Isakov, D. V. Isakov
doaj
Secondary immune deficiency. Do we always need immunomodulators?
, 2014 Respiratory infectious diseases represent one of the most common pathologies in outpatient care. Use of immunomodulators in multimodal treatment of infectious and inflammatory diseases has been widely discussed recently.
A. A. Martynov-radushinskiy, L. V. Luss
core +1 more source
AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing
Advanced Science, EarlyView.A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li +8 more
wiley +1 more source