Results 61 to 70 of about 48,894 (301)

Good Preclinical Study, as an Obligatory Stage in Design and Clinical Use of New Medicinal Preparations

Антибиотики и Химиотерапия, 2020
Preclinical studies are investigations, performed in vitro and in vivo (on animals) prior to clinical trials in men. They play the main role in design of medicinal preparations.
A. N. Vasilyev
doaj  

Nosocomial Infections in COVID-19 Patients Treated with Immunomodulators: A Narrative Review

, 2022
Nosocomial infections pose an imminent challenge to hospitalized Coronavirus disease-19 (COVID-19) patients due to complex interplay of dysregulated immune response combined with immunomodulator therapy.
Gayatri Narayan, Amos Lal, Kevin John John, Chidambaram Ramasamy, Ajay Kumar Mishra   +4 more
core   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction

Molecules, 2018
This review focuses on the biological action of the compounds from the group of substituted 1,3,4-thiadiazines on stress response and myocardial infarction.
Alexey P. Sarapultsev, Pavel M. Vassiliev, Petr A. Sarapultsev, Oleg N. Chupakhin, Laura R. Ianalieva, Larisa P. Sidorova   +5 more
doaj   +1 more source

Immunomodulators Used in Cattle

, 1998
There are numerous substances that cause the suppression and/or the enhancement of non-specific and/or specific immunity. These substances are collectively referred to as immunomodulators.
Schultz, R. D.
core   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Recent advances in immune-related therapies for bullous pemphigoid

Pifu-xingbing zhenliaoxue zazhi
Bullous pemphigoid (BP) is a common autoimmune blistering skin disease characterized by tense blisters and severe pruritus, significantly impacting the quality of life of affected patients.
LV Yansi, WANG Bin, GUAN Lvxin, GAN Ziqin, WEN Ziping, YU Na, MA Li, XUE Ruzeng, HOU Suchun   +8 more
doaj   +1 more source

Recent advances using immunomodulators for inflammatory bowel disease

, 2013
Use of the immunomodulators thiopurines and methotrexate (MTX) in the treatment of inflammatory bowel disease (IBD), i.e., Crohn's disease and ulcerative colitis (UC), is considered to be good clinical practice.
Rogler, Gerhard, Bjerrum, Jacob Tveiten, Nielsen, Ole Haagen, Herfarth, Hans   +3 more
core   +1 more source

Photocontrolled Spatiotemporal Delivery of DNA Immunomodulators for Enhancing Membrane-Targeted Tumor Photodynamic Immunotherapy

, 2022
Immunotherapy is emerging as a paradigm-shifting modality for treatment cancer. However, systemic administration of immunomodulators is usually accompanied by extra-tumor toxicity and adverse immune effects.
Kaixiang Zhang (1592236), Jie Duan (324013), Jinjin Shi (815355), Zhenzhong Zhang (806974), Junjie Liu (193511), Yanrui Ma (1915234), Hua Gao (188700), Danyu Wang (6663506), Jingwen Liu (517390)   +8 more
core   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source