Results 131 to 140 of about 2,997 (217)

Cadherin-17 as a target for the immunoPET of adenocarcinoma

European Journal of Nuclear Medicine and Molecular Imaging
Abstract Purpose Cadherin-17 (CDH17) is a calcium-dependent cell adhesion protein that is overexpressed in several adenocarcinomas, including gastric, colorectal, and pancreatic adenocarcinoma. High levels of CDH17 have been linked to metastatic disease and poor prognoses in patients with these malignancies, fueling ...
Samantha Delaney, Outi Keinänen, Dennis Lam, Andrew L. Wolfe, Takao Hamakubo, Brian M. Zeglis   +5 more
openaire   +2 more sources

Physics of pure and non-pure positron emitters for PET: a review and a discussion [PDF]

, 2016

core   +1 more source

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Antitumor Activity in Colorectal Cancer. [PDF]

As colorectal cancer remains a leading cause of cancer-related death, identifying therapeutic targets and approaches is essential to improve patient outcomes.
AghaAmiri, Solmaz, Anami, Yasuaki, Azhdarinia, Ali, Carmon, Kendra S, Ghosh, Sukhen C, Guernsey-Biddle, Cara, High, Peyton C, Jacob, Joan, Liang, Zhengdong, Rowe, Julie, Subramanian, Shraddha, Tran, Ha, Tsuchikama, Kyoji   +12 more
core   +2 more sources

Modulation of HER2 internalization enhances single-dose antibody-drug potency in HER2+ gastric cancer

Scientific Reports
HER2 is a membrane receptor tyrosine kinase overexpressed in 18–20% of gastric tumors. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that targets HER2-positive (HER2+) cancer cells with a chemotherapeutic agent, emtansine.
Abbey Zidel, Alex Benton, Emma Brown, Shayla Shmuel, Alex Vanover, Sandeep Surendra Panikar, Ron Bose, Haeseong Park, Andrew A. Davis, Patrícia M. R. Pereira   +9 more
doaj   +1 more source

Bifunctional octadentate pseudopeptides as Zirconium-89 chelators for immuno-PET applications

EJNMMI Radiopharmacy and Chemistry
Background Positron emission tomography (PET) is a highly sensitive method that provides fine resolution images, useful in the field of clinical diagnostics.
Valentina Albanese, Chiara Roccatello, Salvatore Pacifico, Remo Guerrini, Delia Preti, Silvia Gentili, Matteo Tegoni, Maurizio Remelli, Denise Bellotti, Jonathan Amico, Giancarlo Gorgoni, Emiliano Cazzola   +11 more
doaj   +1 more source

Site-Specifically Labeled Immunoconjugates for Molecular Imaging—Part 1: Cysteine Residues and Glycans [PDF]

, 2016

core   +1 more source

p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging [PDF]

, 2009
Lars R. Perk, Maria J. W. D. Vosjan, Gerard W. M. Visser, Marianne Budde, Paul Jurek, Garry E. Kiefer, Guus A. M. S. van Dongen, PJ Carter, GAMS Dongen van, AM Wu, TK Nayak, I Verel, E Dijkers, LR Perk, PKE Borjesson, WB Nagengast, I Verel, I Verel, A Brouwers, LR Perk, J Mendelsohn, AH Schrijvers, SR Rangan, MJ Welters, T Lindmo, CF Meares, LR Perk, HWAM Jong de, AM Loening, A Yokoyama, M Koizumi, S Pochon, WE Meijs, S Liu, FB Gog van, DL Kukis, MC Chakrabarti   +36 more
core   +1 more source

ImmunoPET of urokinase plasminogen activator (uPA) system: broad applicability in cancer imaging [PDF]

, 2016
Chen, Daiqin, Dougherty, Casey A., Hong, Hao, Mazar, Andrew P., Severin, Gregory, Yang, Dongzhi   +5 more
core  

Delta-Like Ligand 3 Expression and Functional Imaging in Gastroenteropancreatic Neuroendocrine Neoplasms. [PDF]

JCO Precis Oncol
Thummalapalli R, Tendler S, Chou JF, Tarcan ZC, Porfido C, Willner J, Linkov I, Bhanot U, Cooper AJ, Xu J, Harding JJ, Rekhtman N, Tang LH, Rudin CM, Janjigian YY, Schöder H, Porier JT, Shia J, Basturk O, Reidy-Lagunes D, Capanu M, Lewis JS, Bodei L, Dunphy MP, Raj N.   +24 more
europepmc   +1 more source

Synthesis and Evaluation of D8W, an Octadentate Desferrioxamine Analogue with Enhanced Water Solubility Designed for ⁸⁹Zr-ImmunoPET Imaging. [PDF]

Mol Pharm
Wood JL, Ghosh S, Rosser CA, Feeney SV, Brown CJM, Fletcher NL, Wheatcroft MP, Thurecht KJ, Codd R.   +8 more
europepmc   +1 more source