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GPC3-targeted immunoPET imaging of hepatocellular carcinomas
European Journal of Nuclear Medicine and Molecular Imaging, 2022Early detection of hepatocellular carcinoma (HCC) remains a clinical challenge. Glypican 3 (GPC3) is a proteoglycan highly specific for HCC and is a potential diagnostic and therapeutic target for HCC. This work aims to develop GPC3-targeted immuno-positron emission tomography (immunoPET) imaging strategies and to assess the diagnostic values in ...
Shuxian An +7 more
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ImmunoPET: harnessing antibodies for imaging immune cells
Molecular Imaging and Biology, 2021Dramatic, but uneven, progress in the development of immunotherapies for cancer has created a need for better diagnostic technologies including innovative non-invasive imaging approaches. This review discusses challenges and opportunities for molecular imaging in immuno-oncology and focuses on the unique role that antibodies can fill.
Anna M. Wu, Neeta Pandit-Taskar
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Revista Española de Medicina Nuclear e Imagen Molecular (English Edition), 2022
Due to increase of immunotherapy in oncology, it is essential to have a biological characterization of tumors. Knowing which antigens are expressed both on the surface of the tumor cell and at tumor microenvironment in order to predict the tretment response different therapeutic antibodies, has become a need.
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Due to increase of immunotherapy in oncology, it is essential to have a biological characterization of tumors. Knowing which antigens are expressed both on the surface of the tumor cell and at tumor microenvironment in order to predict the tretment response different therapeutic antibodies, has become a need.
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EGFR-Targeted ImmunoPET of UMUC3 Orthotopic Bladder Tumors
Molecular Imaging and Biology, 2022Immuno-positron emission tomography (immunoPET) combines the specificity of an antibody with the sensitivity of PET to image dysregulated pathways in cancer. This study examines the performance of immunoPET using the radioimmunoconjugate [89Zr]Zr-DFO-Panitumumab to detect epidermal growth factor receptor (EGFR) expression in an orthotopic model of ...
Tran T, Hoang +5 more
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Trastuzumab-conjugated oxine-based ligand for [89Zr]Zr4+ immunoPET
Journal of Inorganic Biochemistry, 2022A new, bifunctional chelating ligand for immuno-Positron Emission Tomography (PET) was designed, synthesized, and conjugated to Trastuzumab for a proof-of-concept study with 89Zr. H4neunox was synthesized from the tris(2-aminoethyl)amine backbone, decorated with 8-hydroxyquinoline moieties, and utilizes a primary amine for functionalization.
Lily, Southcott +6 more
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Copper-64-immunoPET imaging: bench to bedside
The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 2020Positron emission tomography (PET) is a growing non-invasive diagnostic and molecular imaging tool in nuclear medicine, that is used to identify several diseases including cancer. The immunoPET probe is made up of monoclonal antibodies (mAbs) or its fragments or similar molecules that tagged with positron radioisotopes (68Ga, 64Cu, 89Zr) bound together
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Methods for the Production of Radiolabeled Bioagents for ImmunoPET
2023Immunoglobulin-based positron emission tomography (ImmunoPET) is making increasingly significant contributions to the nuclear imaging toolbox. The exquisite specificity of antibodies combined with the high-resolution imaging of PET enables clinicians and researchers to localize diseases, especially cancer, with a high degree of spatial certainty.
Alejandro, Arroyo +2 more
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Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET
Nuclear Medicine and Biology, 2010Three thiol reactive reagents were developed for the chemoselective conjugation of desferrioxamine (Df) to a monoclonal antibody via engineered cysteine residues (thio-trastuzumab). The in vitro stability and in vivo imaging properties of site-specifically radiolabeled (89)Zr-Df-thio-trastuzumab conjugates were investigated.The amino group of ...
Jeff N, Tinianow +10 more
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