Results 181 to 190 of about 2,997 (217)

ImmunoPET Imaging of Nectin4 Expression in Gastric and Bladder Cancer Using [64Cu]Cu-NOTA-Padcev.

Molecular Pharmaceutics
Nectin4 is a tumor-associated antigen that is highly expressed in various solid tumors and is associated with tumor progression and poor prognosis. We performed an ImmunoPET imaging study to assess Nectin4 expression in gastric and bladder cancer models ...
Wenpeng Huang, Liming Li, Yutong Liang, Qi Yang, J. Mixdorf, Jonathan W. Engle, Yu Fan, L. Kang, Weibo Cai   +8 more
semanticscholar   +1 more source

ImmunoPET of CD146 in Orthotopic and Metastatic Breast Cancer Models

Bioconjugate Chemistry, 2021
The overexpression of CD146 in breast cancer is considered a hallmark of tumor progression and metastasis, particularly in triple negative breast cancer. Aimed at imaging differential CD146 expressions in breast cancer, a noninvasive method for predictive prognosis and diagnosis was investigated using a 64Cu-labeled CD146-specific monoclonal antibody ...
Cuicui Li, Lei Kang, Kevin Fan, Carolina A. Ferreira, Kaelyn V. Becker, Nan Huo, Hanxiao Liu, Yunan Yang, Jonathan W. Engle, Rongfu Wang, Xiaojie Xu, Dawei Jiang, Weibo Cai   +12 more
openaire   +2 more sources

Evaluation of ImmunoPET in the efficacy and prognosis of immunotherapy for lung cancer.

Biochimica et biophysica acta. Reviews on cancer
Advances in immune oncology have established immunotherapy as the first-line standard treatment for lung cancer; however, its efficacy remains limited to a subset of patients.
Yiran Liang, Mei Xie, Xuefeng Zang, Xin Zhang, Xinying Xue   +4 more
semanticscholar   +1 more source

Abstract A032: Targeting pancreatic cancer senescence with ImmunoPET

Cancer Research, 2022
Abstract Pancreatic cancer is the fourth leading cause of cancer-related deaths for men and women, with five-year overall survival rates around 10 percent. Despite years of cancer research and new immunotherapy solutions, pancreatic cancer is still mainly treated by chemotherapies, starting with gemcitabine.
Edwin C. Pratt, Riccardo Mezzadra, Tara Viray, Spencer Kaminsky, Scott W. Lowe, Jason S. Lewis   +5 more
openaire   +1 more source

Development and Preclinical Validation of a Novel 89Zr-Labeled BCMA-Targeting Antibody for ImmunoPET Imaging: Application in Multiple Myeloma Models and First-In-Nonhuman-Primates.

Journal of Medicinal Chemistry
B-cell maturation antigen (BCMA) is a clinically validated biomarker and therapeutic target in multiple myeloma (MM). Here, we report the design, synthesis, and preclinical evaluation of an immunoPET probe, [89Zr]Zr-DFO-PFBH0L0, derived from a novel ...
Tianyao Wang, Qi Yang, Wenpeng Huang, Xinyao Sun, Youlan Lei, Hui Xu, Lele Song, Xiaojiang Duan, Futao Liu, Wenzhi Wang, Zheng Bao, Jinquan Gao, Feng Wang, L. Kang   +13 more
semanticscholar   +1 more source

68Ga-NOTA-m-SNA006: A Next-Generation CD8-Targeting Nanobody Probe to Enhance Renal and Hepatic Clearance in Noninvasive ImmunoPET Imaging.

Molecular Pharmaceutics
The 68Ga-labeled nanobody SNA006 marks a significant advancement in noninvasive immunoPET imaging of CD8+ T cells, facilitating real-time tracking of cellular immune responses in cancer, yet its pharmacokinetic properties remain suboptimal.
Tukang Peng, Chao Wang, Jun Wen, Qingyu Zhang, Cheng Wang, Chuncheng Lv, Fuqiang Du, Zhoumi Hu, Tao Xu, Gang Huang, Jianjun Liu, Haitao Zhao   +11 more
semanticscholar   +1 more source

Noninvasive ImmunoPET imaging of PD-L1 expression in non-small cell lung cancer and bladder cancer using [89Zr]Zr-DFO-Durvalumab.

Colloids and Surfaces A: Physicochemical and Engineering Aspects
Purpose ImmunoPET imaging of PD-L1 has emerged as a promising strategy for patient stratification and treatment response monitoring in immunotherapy. This study aimed to evaluate [89Zr]Zr-DFO-Durvalumab in noninvasive imaging of PD-L1 expression in non ...
Wenpeng Huang, Fangfang Chao, Jessica C. Hsu, Xinyao Sun, Todd E. Barnhart, J. Engle, Xingmin Han, L. Kang, Weibo Cai   +8 more
semanticscholar   +1 more source

ImmunoPET for mesothelin positive tissues using bio-orthogonal in-vivo click chemistry.

Nuclear Medicine and Biology
Mesothelin is a membrane bound antigen overexpressed in a wide array of cancers including ovarian, pancreatic, lung, and triple negative breast cancers.
Edwin C. Pratt, Komal Mandleywala, David Bauer, Alexander Bolaender, Grace Chao, Mark A Castanares, Emily C Collins, Jason S. Lewis   +7 more
semanticscholar   +1 more source

Emerging Role of ImmunoPET in Receptor Targeted Cancer Therapy

Current Drug Delivery, 2011
ImmunoPET is a non-invasive imaging technology based on tracking and quantification of radiolabeled monoclonal antibodies, antibody fragments and peptides in vivo. The knowledge of distribution and expression levels of a given receptor is a key for successful receptor targeted cancer therapy.
Jan, Marik, Jagath R, Junutula
openaire   +2 more sources

Exploring utilities of [64Cu]Cu-DOTA-trastuzumab immunoPET in breast cancer: a systematic review and meta-analysis

Nuclear medicine communications
[64Cu]Cu-DOTA-trastuzumab represents a novel immunopositron emission tomography (immunoPET) agent with emerging diagnostic applications in human epidermal growth factor receptor-2 (HER2)-expressing breast cancer (BC).
A. Abdlkadir, Sudqi Allouzi, Shahed Obeidat, Miriam Mikhail-Lette, Hongcheng Shi, A. Al-ibraheem   +5 more
semanticscholar   +1 more source