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Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options
Military Medical Research, 2022 Sepsis is a common complication of combat injuries and trauma, and is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.
Di Liu +15 more
semanticscholar +1 more source
Extracellular Vesicles: New Classification and Tumor Immunosuppression
Biology, 2023 Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are exosomes, microvesicles, and apoptotic bodies.
M. Sheta +3 more
semanticscholar +1 more source
Inflammation Research, 2022 Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of the immune system and leads to the photoaging state which is reminiscent of chronological aging.
A. Salminen +2 more
semanticscholar +1 more source
Tumor-Associated Macrophages Regulate PD-1/PD-L1 Immunosuppression
Frontiers in Immunology, 2022 Anti-programmed cell death 1 (PD-1) or anti-PD-ligand (L) 1 drugs, as classic immune checkpoint inhibitors, are considered promising treatment strategies for tumors.
Y. Pu, Qing Ji
semanticscholar +1 more source
Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression
International Journal of Molecular Sciences, 2022 Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them together. However, lactate has long been recognized as a metabolic waste product.
Lihua Chen +5 more
semanticscholar +1 more source
Exosome-Mediated Immunosuppression in Tumor Microenvironments
Cells, 2022 Exosomes are membranous structures secreted by nearly all cell types. As critical messengers for intercellular communication, exosomes deliver bioactive cargoes to recipient cells and are involved in multiple physiopathological processes, including ...
Qihui Xie +6 more
semanticscholar +1 more source
Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2
Annals of Internal Medicine, 2021 Evidence suggests that immunogenicity to mRNA-based SARS-CoV-2 vaccination in immunosuppressed patients may be reduced. This study assessed the response to 2 doses of mRNA-based SARS-CoV-2 vaccine among 133 participants with underlying chronic ...
P. Deepak +39 more
semanticscholar +1 more source
Melanoma and Immunosuppression [PDF]
Dermatology, 2009 In a recent article, Richtig et al. [1] suggested that immunosuppression may be a risk factor for melanoma development and, in order to support this view, cited a study demonstrating an increased frequency of melanoma in organ transplant recipients receiving long-term immunosuppression [2] .
Belloni Fortina A +4 more
openaire +4 more sources
Pharmacotherapy, 2022 Advances in maintenance immunosuppression over the past three decades have improved solid organ transplantation outcomes dramatically. Uninterrupted access to immunosuppression is paramount to minimize rejection and maintain allograft and patient ...
J. Nelson +11 more
semanticscholar +1 more source