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Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options
Military Medical Research, 2022 Sepsis is a common complication of combat injuries and trauma, and is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.
Di Liu +15 more
semanticscholar +1 more source
Inflammation Research, 2022 Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of the immune system and leads to the photoaging state which is reminiscent of chronological aging.
A. Salminen +2 more
semanticscholar +1 more source
Critical Care, 2023 Background The development of stratification tools based on the assessment of circulating mRNA of genes involved in the immune response is constrained by the heterogeneity of septic patients.
Maxime Bodinier +12 more
doaj +1 more source
Annals of Intensive Care, 2022 Background Lymphopenia is a hallmark of severe coronavirus disease 19 (COVID-19). Similar alterations have been described in bacterial sepsis and therapeutic strategies targeting T cell function such as recombinant human interleukin 7 (rhIL-7) have been ...
Frank Bidar +17 more
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Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression
International Journal of Molecular Sciences, 2022 Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them together. However, lactate has long been recognized as a metabolic waste product.
Lihua Chen +5 more
semanticscholar +1 more source
Extracellular Vesicles: New Classification and Tumor Immunosuppression
Biology, 2023 Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are exosomes, microvesicles, and apoptotic bodies.
M. Sheta +3 more
semanticscholar +1 more source
Annals of Intensive Care, 2022 Background Although multiple individual immune parameters have been demonstrated to predict the occurrence of secondary infection after critical illness, significant questions remain with regards to the selection, timing and clinical utility of such ...
Jan-Alexis Tremblay +12 more
doaj +1 more source
Tumor-Associated Macrophages Regulate PD-1/PD-L1 Immunosuppression
Frontiers in Immunology, 2022 Anti-programmed cell death 1 (PD-1) or anti-PD-ligand (L) 1 drugs, as classic immune checkpoint inhibitors, are considered promising treatment strategies for tumors.
Y. Pu, Qing Ji
semanticscholar +1 more source
Frontiers in Immunology, 2022 BackgroundMucormycosis is a deadly fungal infection that mainly affects severely immunocompromised patients. We report herein the case of a previously immunocompetent adult woman who developed invasive cutaneous mucormycosis after severe burn injuries ...
Dina M. Tawfik +22 more
doaj +1 more source
Macromolecular Immunosuppressants [PDF]
Biotechnology Journal, 2005 AbstractRecombinant immunosuppressants have come of age and represent a significant class of quite diverse drugs. They target extracellular molecules, and either label or inhibit them. Those targets are soluble factors or membrane proteins almost all of which are components of a very complex molecular network of communication and amplification. Notably,
Theo, Dingermann, Ilse, Zündorf
openaire +2 more sources