Results 11 to 20 of about 556,132 (392)
Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options
Military Medical Research, 2022 Sepsis is a common complication of combat injuries and trauma, and is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection.
Di Liu +15 more
semanticscholar +1 more source
Inflammation Research, 2022 Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of the immune system and leads to the photoaging state which is reminiscent of chronological aging.
A. Salminen +2 more
semanticscholar +1 more source
Extracellular Vesicles: New Classification and Tumor Immunosuppression
Biology, 2023 Simple Summary Extracellular vesicles (EVs) are cell-derived membrane-surrounded vesicles that carry bioactive molecules and deliver them to recipient cells. Classical EVs are exosomes, microvesicles, and apoptotic bodies.
M. Sheta +3 more
semanticscholar +1 more source
Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression
International Journal of Molecular Sciences, 2022 Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them together. However, lactate has long been recognized as a metabolic waste product.
Lihua Chen +5 more
semanticscholar +1 more source
Tumor-Associated Macrophages Regulate PD-1/PD-L1 Immunosuppression
Frontiers in Immunology, 2022 Anti-programmed cell death 1 (PD-1) or anti-PD-ligand (L) 1 drugs, as classic immune checkpoint inhibitors, are considered promising treatment strategies for tumors.
Y. Pu, Qing Ji
semanticscholar +1 more source
Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation
Nature Communications, 2023 Acute inflammation can either resolve through immunosuppression or persist, leading to chronic inflammation. These transitions are driven by distinct molecular and metabolic reprogramming of immune cells.
Marlies Cortés +17 more
semanticscholar +1 more source
Ferroptosis in immunostimulation and immunosuppression
Immunological Reviews, 2023 Ferroptosis is a form of iron‐dependent regulated cell death characterized by the accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic cell death. While it plays a crucial role in maintaining the overall health and
D. Tang, G. Kroemer, Rui Kang
semanticscholar +1 more source
Sepsis-Induced Immunosuppression.
Annual Review of Physiology, 2021 Sepsis is expected to have a substantial impact on public health and cost as its prevalence increases. Factors contributing to increased prevalence include a progressively aging population, advances in the use of immunomodulatory agents to treat a rising
L. Torres, P. Pickkers, T. van der Poll
semanticscholar +1 more source
Dynamic LTR retrotransposon transcriptome landscape in septic shock patients
Critical Care, 2020 Background Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have explored the complex and dynamic transcriptome modulations observed in sepsis patients, but a large fraction ...
Marine Mommert +15 more
doaj +1 more source
Frontiers in Immunology, 2021 IntroductionWe analysed blood DNAemia of TTV and four herpesviruses (CMV, EBV, HHV6, and HSV-1) in the REAnimation Low Immune Status Marker (REALISM) cohort of critically ill patients who had presented with either sepsis, burns, severe trauma, or major ...
François Mallet +18 more
doaj +1 more source