Results 11 to 20 of about 514,735 (343)
Sepsis-Induced Immunosuppression.
Annual Review of Physiology, 2021 Sepsis is expected to have a substantial impact on public health and cost as its prevalence increases. Factors contributing to increased prevalence include a progressively aging population, advances in the use of immunomodulatory agents to treat a rising
L. Torres, P. Pickkers, T. van der Poll
semanticscholar +1 more source
Pediatric Liver Transplantation: Then and Now [PDF]
, 2020 This paper reviews the past 50 years of liver transplantation in children from the perspective of patient demographics, perioperative patient management, surgical techniques, immunosuppression and patient ...
Banh, DPT +4 more
core +1 more source
To be (immunosuppressive) or not to be [PDF]
Nature Reviews Cancer, 2019 Singhal et al. characterized tumour-infiltrating monocyte and macrophage lineage cells in patients with early stage lung cancer and found that, contrary to data in mouse models, the function of these cells might not be primarily immunosuppressive.
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Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation [PDF]
, 2006 Objective: Heavy post-transplant immunosuppression may contribute to long-term immunosuppression dependence by subverting tolerogenic mechanisms; thus, we sought to determine if this undesirable consequence could be mitigated by pretransplant lymphoid ...
Abhay N. Vats +52 more
core +1 more source
Journal of the California Dental Association, 2008 This paper provides a brief introduction to some of the common immunosuppressants used in oral medicine, the prevention and treatment of oral adverse effects of immunosuppressants, and considerations for dental treatment in patients taking immunosuppressants.
Nita, Chainani-Wu, Timothy C, Wu
openaire +2 more sources
Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response
Nature, 2018 Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T cells to elicit the immune checkpoint response1,2.
Gang Chen +44 more
semanticscholar +1 more source
Lactate: The Mediator of Metabolism and Immunosuppression
Frontiers in Endocrinology, 2022 The Warburg effect, one of the hallmarks of tumors, produces large amounts of lactate and generates an acidic tumor microenvironment via using glucose for glycolysis.
Yuanyuan Zhang +11 more
semanticscholar +1 more source
Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]
, 2018 Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A. +6 more
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Cardiovascular effects of immunosuppression agents
Frontiers in Cardiovascular Medicine, 2022 Immunosuppressive medications are widely used to treat patients with neoplasms, autoimmune conditions and solid organ transplants. Key drug classes, namely calcineurin inhibitors, mammalian target of rapamycin (mTOR) inhibitors, and purine synthesis ...
Aly Elezaby +2 more
semanticscholar +1 more source
Pediatric Nephrology, 2017 Immunosuppressive drugs for solid organ transplantation are critical dose drugs with a narrow therapeutic index. Many of the most commonly used innovator drugs are off patent and have been replicated by generic counterparts, often at substantial cost-savings to the patient.
Mara Medeiros +4 more
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