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The Effect of Immunosuppressive Treatment on Torque Teno Virus Load in Lung Transplant Recipients: A Preliminary Study [PDF]
VirusesAfter transplantation, systematically monitoring and assessing the risk of transplanted organ rejection is crucial. Current methods involving immunosuppressant monitoring, the assessment of organ function, and biopsies are insufficient for predicting ...Marek Ochman, Dagmara Galle, Anna Kowal, Magdalena Królikowska, Fryderyk Zawadzki, Anita Stanjek-Cichoracka, Anna Łaszewska, Elżbieta Chełmecka, Tomasz Hrapkowicz +8 moredoaj +2 more sourcesInterferon gamma as an immune modulating adjunct therapy for invasive mucormycosis after severe burn – A case report
Frontiers in Immunology, 2022 BackgroundMucormycosis is a deadly fungal infection that mainly affects severely immunocompromised patients. We report herein the case of a previously immunocompetent adult woman who developed invasive cutaneous mucormycosis after severe burn injuries ...Dina M. Tawfik, Dina M. Tawfik, Caroline Dereux, Caroline Dereux, Jan-Alexis Tremblay, Jan-Alexis Tremblay, Andre Boibieux, Fabienne Braye, Jean-Baptiste Cazauran, Meja Rabodonirina, Elisabeth Cerrato, Elisabeth Cerrato, Audrey Guichard, Audrey Guichard, Fabienne Venet, Fabienne Venet, Guillaume Monneret, Guillaume Monneret, Didier Payen, Anne-Claire Lukaszewicz, Anne-Claire Lukaszewicz, Julien Textoris, Julien Textoris +22 moredoaj +1 more sourceCharacterization of Circulating IL-10-Producing Cells in Septic Shock Patients: A Proof of Concept Study
Frontiers in Immunology, 2021 Sepsis is a worldwide health priority characterized by the occurrence of severe immunosuppression associated with increased risk of death and secondary infections.Astrid Fabri, Astrid Fabri, Khalil Kandara, Khalil Kandara, Rémy Coudereau, Rémy Coudereau, Morgane Gossez, Morgane Gossez, Paul Abraham, Céline Monard, Céline Monard, Martin Cour, Thomas Rimmelé, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret, Guillaume Monneret, Fabienne Venet, Fabienne Venet +18 moredoaj +1 more sourceConsensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and the International Society for Heart and Lung Transplantation
Pharmacotherapy, 2022 Advances in maintenance immunosuppression over the past three decades have improved solid organ transplantation outcomes dramatically. Uninterrupted access to immunosuppression is paramount to minimize rejection and maintain allograft and patient ...J. Nelson, N. Alvey, L. Bowman, Jamie Schulte, M. Segovia, J. McDermott, H. Te, N. Kapila, D. Levine, R. Gottlieb, J. Oberholzer, M. Campara +11 moresemanticscholar +1 more sourcePrimary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis
Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022 One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract
Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...Si‐Yuan Chen, Meng‐Meng Ji, Peng‐Peng Xu, Wei‐Li Zhao +3 morewiley +1 more sourceMortality Prediction in Sepsis With an Immune-Related Transcriptomics Signature: A Multi-Cohort Analysis
Frontiers in Medicine, 2022 BackgroundNovel biomarkers are needed to progress toward individualized patient care in sepsis. The immune profiling panel (IPP) prototype has been designed as a fully-automated multiplex tool measuring expression levels of 26 genes in sepsis patients to Louis Kreitmann, Louis Kreitmann, Maxime Bodinier, Maxime Bodinier, Aurore Fleurie, Aurore Fleurie, Katia Imhoff, Marie-Angelique Cazalis, Marie-Angelique Cazalis, Estelle Peronnet, Estelle Peronnet, Elisabeth Cerrato, Elisabeth Cerrato, Claire Tardiveau, Claire Tardiveau, Filippo Conti, Filippo Conti, Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos, Julien Textoris, Guillaume Monneret, Guillaume Monneret, Sophie Blein, Karen Brengel-Pesce, Karen Brengel-Pesce +25 moredoaj +1 more sourceSepsis-Induced Immunosuppression.
Annual Review of Physiology, 2021 Sepsis is expected to have a substantial impact on public health and cost as its prevalence increases. Factors contributing to increased prevalence include a progressively aging population, advances in the use of immunomodulatory agents to treat a rising L. Torres, P. Pickkers, T. van der Pollsemanticscholar +1 more sourceA novel virotherapy encoding human interleukin-7 improves ex vivo T lymphocyte functions in immunosuppressed patients with septic shock and critically ill COVID-19
Frontiers in Immunology, 2022 A majority of patients with sepsis surviving the first days in intensive care units (ICU) enter a state of immunosuppression contributing to their worsening.Morgane Crausaz, Morgane Crausaz, Guillaume Monneret, Guillaume Monneret, Filippo Conti, Anne-Claire Lukaszewicz, Anne-Claire Lukaszewicz, Jean-Baptiste Marchand, Perrine Martin, Geneviève Inchauspé, Fabienne Venet, Fabienne Venet +11 moredoaj +1 more sourceTCR activation mimics CD127lowPD-1high phenotype and functional alterations of T lymphocytes from septic shock patients
Critical Care, 2019 Background Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death.Julie Mouillaux, Camille Allam, Morgane Gossez, Thomas Uberti, Benjamin Delwarde, Jack Hayman, Thomas Rimmelé, Julien Textoris, Guillaume Monneret, Estelle Peronnet, Fabienne Venet +10 moredoaj +1 more sourceMonocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
Frontiers in Immunology, 2021 Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner.Maxime Bodinier, Estelle Peronnet, Karen Brengel-Pesce, Filippo Conti, Thomas Rimmelé, Julien Textoris, Christophe Vedrine, Laurence Quemeneur, Andrew D. Griffiths, Lionel K. Tan, Fabienne Venet, Fabienne Venet, Delphine Maucort-Boulch, Delphine Maucort-Boulch, Delphine Maucort-Boulch, Guillaume Monneret, the REALISM study group +16 moredoaj +1 more source