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The Effect of Immunosuppressive Treatment on Torque Teno Virus Load in Lung Transplant Recipients: A Preliminary Study [PDF]

open access: yesViruses
After transplantation, systematically monitoring and assessing the risk of transplanted organ rejection is crucial. Current methods involving immunosuppressant monitoring, the assessment of organ function, and biopsies are insufficient for predicting ...
Marek Ochman   +8 more
doaj   +2 more sources

Interferon gamma as an immune modulating adjunct therapy for invasive mucormycosis after severe burn – A case report

open access: yesFrontiers in Immunology, 2022
BackgroundMucormycosis is a deadly fungal infection that mainly affects severely immunocompromised patients. We report herein the case of a previously immunocompetent adult woman who developed invasive cutaneous mucormycosis after severe burn injuries ...
Dina M. Tawfik   +22 more
doaj   +1 more source

Characterization of Circulating IL-10-Producing Cells in Septic Shock Patients: A Proof of Concept Study

open access: yesFrontiers in Immunology, 2021
Sepsis is a worldwide health priority characterized by the occurrence of severe immunosuppression associated with increased risk of death and secondary infections.
Astrid Fabri   +18 more
doaj   +1 more source

Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and the International Society for Heart and Lung Transplantation

open access: yesPharmacotherapy, 2022
Advances in maintenance immunosuppression over the past three decades have improved solid organ transplantation outcomes dramatically. Uninterrupted access to immunosuppression is paramount to minimize rejection and maintain allograft and patient ...
J. Nelson   +11 more
semanticscholar   +1 more source

Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis

open access: yesAging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022
One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen   +3 more
wiley   +1 more source

Mortality Prediction in Sepsis With an Immune-Related Transcriptomics Signature: A Multi-Cohort Analysis

open access: yesFrontiers in Medicine, 2022
BackgroundNovel biomarkers are needed to progress toward individualized patient care in sepsis. The immune profiling panel (IPP) prototype has been designed as a fully-automated multiplex tool measuring expression levels of 26 genes in sepsis patients to
Louis Kreitmann   +25 more
doaj   +1 more source

Sepsis-Induced Immunosuppression.

open access: yesAnnual Review of Physiology, 2021
Sepsis is expected to have a substantial impact on public health and cost as its prevalence increases. Factors contributing to increased prevalence include a progressively aging population, advances in the use of immunomodulatory agents to treat a rising
L. Torres, P. Pickkers, T. van der Poll
semanticscholar   +1 more source

A novel virotherapy encoding human interleukin-7 improves ex vivo T lymphocyte functions in immunosuppressed patients with septic shock and critically ill COVID-19

open access: yesFrontiers in Immunology, 2022
A majority of patients with sepsis surviving the first days in intensive care units (ICU) enter a state of immunosuppression contributing to their worsening.
Morgane Crausaz   +11 more
doaj   +1 more source

TCR activation mimics CD127lowPD-1high phenotype and functional alterations of T lymphocytes from septic shock patients

open access: yesCritical Care, 2019
Background Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death.
Julie Mouillaux   +10 more
doaj   +1 more source

Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients

open access: yesFrontiers in Immunology, 2021
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner.
Maxime Bodinier   +16 more
doaj   +1 more source

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