Results 21 to 30 of about 521,863 (391)
Frontiers in Immunology, 2022 A majority of patients with sepsis surviving the first days in intensive care units (ICU) enter a state of immunosuppression contributing to their worsening.
Morgane Crausaz +11 more
doaj +1 more source
Critical Care, 2019 Background Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death.
Julie Mouillaux +10 more
doaj +1 more source
Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
Frontiers in Immunology, 2021 Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner.
Maxime Bodinier +16 more
doaj +1 more source
To be (immunosuppressive) or not to be [PDF]
Nature Reviews Cancer, 2019 Singhal et al. characterized tumour-infiltrating monocyte and macrophage lineage cells in patients with early stage lung cancer and found that, contrary to data in mouse models, the function of these cells might not be primarily immunosuppressive.
openaire +3 more sources
Dynamic LTR retrotransposon transcriptome landscape in septic shock patients
Critical Care, 2020 Background Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have explored the complex and dynamic transcriptome modulations observed in sepsis patients, but a large fraction ...
Marine Mommert +15 more
doaj +1 more source
Frontiers in Immunology, 2021 IntroductionWe analysed blood DNAemia of TTV and four herpesviruses (CMV, EBV, HHV6, and HSV-1) in the REAnimation Low Immune Status Marker (REALISM) cohort of critically ill patients who had presented with either sepsis, burns, severe trauma, or major ...
François Mallet +18 more
doaj +1 more source
Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response
Nature, 2018 Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T cells to elicit the immune checkpoint response1,2.
Gang Chen +44 more
semanticscholar +1 more source
Lactate: The Mediator of Metabolism and Immunosuppression
Frontiers in Endocrinology, 2022 The Warburg effect, one of the hallmarks of tumors, produces large amounts of lactate and generates an acidic tumor microenvironment via using glucose for glycolysis.
Yuanyuan Zhang +11 more
semanticscholar +1 more source
Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation [PDF]
, 2006 Objective: Heavy post-transplant immunosuppression may contribute to long-term immunosuppression dependence by subverting tolerogenic mechanisms; thus, we sought to determine if this undesirable consequence could be mitigated by pretransplant lymphoid ...
Abhay N. Vats +52 more
core +1 more source
Journal of the California Dental Association, 2008 This paper provides a brief introduction to some of the common immunosuppressants used in oral medicine, the prevention and treatment of oral adverse effects of immunosuppressants, and considerations for dental treatment in patients taking immunosuppressants.
Nita, Chainani-Wu, Timothy C, Wu
openaire +2 more sources