Results 21 to 30 of about 392,479 (342)
Sepsis-Induced Immunosuppression.
Annual Review of Physiology, 2021 Sepsis is expected to have a substantial impact on public health and cost as its prevalence increases. Factors contributing to increased prevalence include a progressively aging population, advances in the use of immunomodulatory agents to treat a rising
L. Torres, P. Pickkers, T. van der Poll
semanticscholar +1 more source
Critical Care, 2020 Background Decreased monocytic (m)HLA-DR expression is the most studied biomarker of sepsis-induced immunosuppression. To date, little is known about the relationship between sepsis characteristics, such as the site of infection, causative pathogen, or ...
Guus P. Leijte +8 more
doaj +1 more source
Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
Frontiers in Immunology, 2021 Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner.
Maxime Bodinier +16 more
doaj +1 more source
Frontiers in Immunology, 2022 Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex
Claire Tardiveau +39 more
doaj +1 more source
Exosome-Mediated Immunosuppression in Tumor Microenvironments
Cells, 2022 Exosomes are membranous structures secreted by nearly all cell types. As critical messengers for intercellular communication, exosomes deliver bioactive cargoes to recipient cells and are involved in multiple physiopathological processes, including ...
Qi-hui Xie +6 more
semanticscholar +1 more source
Critical Care, 2017 Background Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we
Jonathan Plassais +7 more
doaj +1 more source
Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2
Annals of Internal Medicine, 2021 Evidence suggests that immunogenicity to mRNA-based SARS-CoV-2 vaccination in immunosuppressed patients may be reduced. This study assessed the response to 2 doses of mRNA-based SARS-CoV-2 vaccine among 133 participants with underlying chronic ...
P. Deepak +39 more
semanticscholar +1 more source
Early herpes and TTV DNAemia in septic shock patients: a pilot study
Intensive Care Medicine Experimental, 2019 Background Septic shock patients exhibit an increased incidence of viral reactivation. Precise timing of such reactivation—as an early marker of immune suppression, or as a consequence of the later—is not known precisely.
François Mallet +18 more
doaj +1 more source
Pediatric Nephrology, 2017 Immunosuppressive drugs for solid organ transplantation are critical dose drugs with a narrow therapeutic index. Many of the most commonly used innovator drugs are off patent and have been replicated by generic counterparts, often at substantial cost-savings to the patient.
Mara Medeiros +4 more
openaire +5 more sources
Journal of Neuroinflammation, 2021 Stroke produces a powerful inflammatory cascade in the brain, but also a suppression of the peripheral immune system, which is also called stroke-induced immunosuppression (SIIS).
Júlia Faura +3 more
semanticscholar +1 more source