Results 21 to 30 of about 353,556 (317)

Dynamic LTR retrotransposon transcriptome landscape in septic shock patients

Critical Care, 2020
Background Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have explored the complex and dynamic transcriptome modulations observed in sepsis patients, but a large fraction ...
Marine Mommert, Olivier Tabone, Audrey Guichard, Guy Oriol, Elisabeth Cerrato, Mélanie Denizot, Valérie Cheynet, Alexandre Pachot, Alain Lepape, Guillaume Monneret, Fabienne Venet, Karen Brengel-Pesce, Julien Textoris, François Mallet, MIPrea Study Group, REALISM Study Group   +15 more
doaj   +1 more source

Herpes DNAemia and TTV Viraemia in Intensive Care Unit Critically Ill Patients: A Single-Centre Prospective Longitudinal Study

Frontiers in Immunology, 2021
IntroductionWe analysed blood DNAemia of TTV and four herpesviruses (CMV, EBV, HHV6, and HSV-1) in the REAnimation Low Immune Status Marker (REALISM) cohort of critically ill patients who had presented with either sepsis, burns, severe trauma, or major ...
François Mallet, Léa Diouf, Léa Diouf, Boris Meunier, Boris Meunier, Magali Perret, Frédéric Reynier, Philippe Leissner, Laurence Quemeneur, Andrew D. Griffiths, Virginie Moucadel, Alexandre Pachot, Fabienne Venet, Guillaume Monneret, Alain Lepape, Thomas Rimmelé, Lionel K. Tan, Karen Brengel-Pesce, Julien Textoris   +18 more
doaj   +1 more source

Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response

Nature, 2018
Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T cells to elicit the immune checkpoint response1,2.
Gang Chen, Alexander C. Huang, Wei Zhang, Wei Zhang, Gao Zhang, Min Wu, Wei Xu, Zi-li Yu, Jian Yang, Jian Yang, Beike Wang, Beike Wang, Honghong Sun, H. Xia, Qiwen Man, Wenqun Zhong, Wenqun Zhong, Leonardo F. Antelo, Bin Wu, X. Xiong, Xiaoming Liu, Lei Guan, Lei Guan, Ting Li, Ting Li, Shujing Liu, Ruifeng Yang, Youtao Lu, Liyun Dong, S. McGettigan, R. Somasundaram, R. Radhakrishnan, G. Mills, Yiling Lu, Junhyong Kim, Youhai H. Chen, Haidong Dong, Yifang Zhao, G. Karakousis, T. Mitchell, L. Schuchter, M. Herlyn, E. Wherry, Xiaowei Xu, Wei Guo   +44 more
semanticscholar   +1 more source

Lactate: The Mediator of Metabolism and Immunosuppression

Frontiers in Endocrinology, 2022
The Warburg effect, one of the hallmarks of tumors, produces large amounts of lactate and generates an acidic tumor microenvironment via using glucose for glycolysis.
Yuanyuan Zhang, Zhaoxin Zhai, J. Duan, Xiangcai Wang, Jinghua Zhong, Longqiu Wu, An Li, Miao Cao, Yanyang Wu, Huaqiu Shi, Jianing Zhong, Zhenli Guo   +11 more
semanticscholar   +1 more source

Use of convalescent plasma in COVID‐19 patients with immunosuppression

Transfusion, 2021
In the absence of effective countermeasures, human convalescent plasma has been widely used to treat severe acute respiratory syndrome coronavirus 2, the causative agent of novel coronavirus disease 19 (COVID‐19), including among patients with innate or ...
Jonathon W. Senefeld, S. Klassen, S. Ford, K. Senese, C. Wiggins, B. Bostrom, M. Thompson, S. Baker, W. Nicholson, Patrick W. Johnson, R. Carter, J. P. Henderson, W. Hartman, L. Pirofski, R. Wright, D. Fairweather, K. A. Bruno, N. Paneth, A. Casadevall, M. Joyner   +19 more
semanticscholar   +1 more source

Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes

Critical Care, 2020
Background Decreased monocytic (m)HLA-DR expression is the most studied biomarker of sepsis-induced immunosuppression. To date, little is known about the relationship between sepsis characteristics, such as the site of infection, causative pathogen, or ...
Guus P. Leijte, Thomas Rimmelé, Matthijs Kox, Niklas Bruse, Céline Monard, Morgane Gossez, Guillaume Monneret, Peter Pickkers, Fabienne Venet   +8 more
doaj   +1 more source

A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients

Frontiers in Immunology, 2022
Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex
Claire Tardiveau, Claire Tardiveau, Guillaume Monneret, Guillaume Monneret, Anne-Claire Lukaszewicz, Anne-Claire Lukaszewicz, Valérie Cheynet, Valérie Cheynet, Elisabeth Cerrato, Elisabeth Cerrato, Katia Imhoff, Katia Imhoff, Estelle Peronnet, Estelle Peronnet, Maxime Bodinier, Maxime Bodinier, Louis Kreitmann, Louis Kreitmann, Sophie Blein, Sophie Blein, Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos, Filippo Conti, Filippo Conti, Morgane Gossez, Morgane Gossez, Marielle Buisson, Hodane Yonis, Martin Cour, Laurent Argaud, Marie-Charlotte Delignette, Florent Wallet, Frederic Dailler, Céline Monard, Karen Brengel-Pesce, Karen Brengel-Pesce, Fabienne Venet, Fabienne Venet, the RICO study group   +39 more
doaj   +1 more source

Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial

Critical Care, 2017
Background Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we
Jonathan Plassais, Fabienne Venet, Marie-Angélique Cazalis, Diane Le Quang, Alexandre Pachot, Guillaume Monneret, Sylvie Tissot, Julien Textoris   +7 more
doaj   +1 more source

Understanding sepsis-induced immunosuppression and organ dysfunctions: from immunosuppression to immunotherapy

Exploration of Immunology, 2022
Sepsis is a life-threatening condition caused by dysregulated host immune response to infection, leading to persistent inflammation followed by immunosuppression.
Dablu Lal Gupta, Tejprakash Sinha, Richa Pathak, Sanjeev Bhoi, D. N. Rao   +4 more
doaj   +1 more source

Early herpes and TTV DNAemia in septic shock patients: a pilot study

Intensive Care Medicine Experimental, 2019
Background Septic shock patients exhibit an increased incidence of viral reactivation. Precise timing of such reactivation—as an early marker of immune suppression, or as a consequence of the later—is not known precisely.
François Mallet, Magali Perret, Trang Tran, Boris Meunier, Audrey Guichard, Olivier Tabone, Marine Mommert, Karen Brengel-Pesce, Fabienne Venet, Alexandre Pachot, Guillaume Monneret, Frederic Reynier, Christophe Védrine, Philippe Leissner, Virginie Moucadel, Alain Lepape, Julien Textoris, MIPrea group, REALISM group   +18 more
doaj   +1 more source