Results 21 to 30 of about 556,132 (392)
Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]
, 2018 Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A. +6 more
core +1 more source
Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response
Nature, 2018 Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T cells to elicit the immune checkpoint response1,2.
Gang Chen +44 more
semanticscholar +1 more source
Critical Care, 2020 Background Decreased monocytic (m)HLA-DR expression is the most studied biomarker of sepsis-induced immunosuppression. To date, little is known about the relationship between sepsis characteristics, such as the site of infection, causative pathogen, or ...
Guus P. Leijte +8 more
doaj +1 more source
Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients
Frontiers in Immunology, 2021 Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner.
Maxime Bodinier +16 more
doaj +1 more source
Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation [PDF]
, 2006 Objective: Heavy post-transplant immunosuppression may contribute to long-term immunosuppression dependence by subverting tolerogenic mechanisms; thus, we sought to determine if this undesirable consequence could be mitigated by pretransplant lymphoid ...
Abhay N. Vats +52 more
core +1 more source
Frontiers in Immunology, 2022 Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex
Claire Tardiveau +39 more
doaj +1 more source
Exosome-Mediated Immunosuppression in Tumor Microenvironments
Cells, 2022 Exosomes are membranous structures secreted by nearly all cell types. As critical messengers for intercellular communication, exosomes deliver bioactive cargoes to recipient cells and are involved in multiple physiopathological processes, including ...
Qi-hui Xie +6 more
semanticscholar +1 more source
Critical Care, 2017 Background Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we
Jonathan Plassais +7 more
doaj +1 more source
Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2
Annals of Internal Medicine, 2021 Evidence suggests that immunogenicity to mRNA-based SARS-CoV-2 vaccination in immunosuppressed patients may be reduced. This study assessed the response to 2 doses of mRNA-based SARS-CoV-2 vaccine among 133 participants with underlying chronic ...
P. Deepak +39 more
semanticscholar +1 more source
Intestinal transplantation in children under FK 506 immunosuppression [PDF]
, 1993 Intestinal transplantation, solitary (n = 3) or in combination with the liver (n = 7), was performed in 10 pediatric patients with intestinal failure. The liver was only replaced if there was liver failure and portal hypertension.
Adrian Casavilla +26 more
core +1 more source