Results 41 to 50 of about 392,479 (342)
Induction immunosuppression and post-transplant diabetes mellitus: a propensity-matched cohort study
Frontiers in Endocrinology, 2023 IntroductionPost-transplant diabetes mellitus (PTDM) is a common complication among cardiac transplant recipients, causing diabetes-related complications and death.
Suruchi K. Gupta +10 more
doaj +1 more source
Melanoma and Immunosuppression [PDF]
Dermatology, 2009 In a recent article, Richtig et al. [1] suggested that immunosuppression may be a risk factor for melanoma development and, in order to support this view, cited a study demonstrating an increased frequency of melanoma in organ transplant recipients receiving long-term immunosuppression [2] .
Belloni Fortina A +4 more
openaire +3 more sources
Frontiers in Nephrology, 2023 Management of immunosuppression in patients with a failing or failed kidney transplant requires a complete assessment of their clinical condition. One of the major considerations in determining immunosuppression is whether or not such an individual is ...
Michelle J. Hickey +2 more
doaj +1 more source
LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs
BMC Genomics, 2018 Background Human Endogenous Retroviruses (HERVs) and Mammalian apparent LTR-retrotransposons (MaLRs) represent the 8% of our genome and are distributed among our 46 chromosomes.
Marine Mommert +13 more
doaj +1 more source
Mechanisms underlying immunosuppression by regulatory cells
Frontiers in ImmunologyRegulatory cells, such as regulatory T cells (Tregs), regulatory B cells (Bregs), and myeloid-derived suppressor cells (MDSCs), play a crucial role in preserving immune tolerance and controlling immune responses during infections to prevent excessive ...
O. Goldmann +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression
British Journal of Cancer, 2018 Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC) differentiate into granulocytes, macrophages and dendritic cells (DCs). This differentiation is impaired under chronic inflammatory conditions, which are typical for tumour ...
Christopher Groth +6 more
semanticscholar +1 more source
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections
JCI Insight, 2020 COVID-19–associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained viral ...
Kenneth E. Remy +20 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source