Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression
British Journal of Cancer, 2018 Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC) differentiate into granulocytes, macrophages and dendritic cells (DCs). This differentiation is impaired under chronic inflammatory conditions, which are typical for tumour ...
Christopher Groth +6 more
semanticscholar +1 more source
Induction immunosuppression and post-transplant diabetes mellitus: a propensity-matched cohort study
Frontiers in Endocrinology, 2023 IntroductionPost-transplant diabetes mellitus (PTDM) is a common complication among cardiac transplant recipients, causing diabetes-related complications and death.
Suruchi K. Gupta +10 more
doaj +1 more source
Cooperative coinfection dynamics on clustered networks [PDF]
Phys. Rev. E 103, 042307 (2021), 2020 Coinfection is the process by which a host that is infected with a pathogen becomes infected by a second pathogen at a later point in time. An immunosuppressant host response to a primary disease can facilitate spreading of a subsequent emergent pathogen among the population.
arxiv +1 more source
Corticosterone selectively decreases humoral immunity in female eiders during incubation [PDF]
J. Exp. Biol. 209 (2006) 4957-4965, 2007 Immunity is hypothesized to share limited resources with other physiological functions and this may partly account for the fitness costs of reproduction. Previous studies have shown that the acquired immunity of female common eider ducks (Somateria mollissima) is suppressed during their incubation, during which they entirely fast.
arxiv +1 more source
LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs
BMC Genomics, 2018 Background Human Endogenous Retroviruses (HERVs) and Mammalian apparent LTR-retrotransposons (MaLRs) represent the 8% of our genome and are distributed among our 46 chromosomes.
Marine Mommert +13 more
doaj +1 more source
Frontiers in Nephrology, 2023 Management of immunosuppression in patients with a failing or failed kidney transplant requires a complete assessment of their clinical condition. One of the major considerations in determining immunosuppression is whether or not such an individual is ...
Michelle J. Hickey +2 more
doaj +1 more source
Spatio-temporal modeling of co-dynamics of smallpox, measles and pertussis in pre-healthcare Finland [PDF]
arXiv, 2023 Infections are known to interact as previous infections may have an effect on risk of succumbing to a new infection. The co-dynamics can be mediated by immunosuppression or -modulation, shared environmental or climatic drivers, or competition for susceptible hosts.
arxiv
Interacting epidemics and coinfection on contact networks [PDF]
PLOS One 8, e71321 (2013), 2013 The spread of certain diseases can be promoted, in some cases substantially, by prior infection with another disease. One example is that of HIV, whose immunosuppressant effects significantly increase the chances of infection with other pathogens. Such coinfection processes, when combined with nontrivial structure in the contact networks over which ...
arxiv +1 more source
PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression
Clinical Cancer Research, 2017 Purpose: To explore whether a cross-talk exists between PARP inhibition and PD-L1/PD-1 immune checkpoint axis, and determine whether blockade of PD-L1/PD-1 potentiates PARP inhibitor (PARPi) in tumor suppression.
Shiping Jiao +17 more
semanticscholar +1 more source
Sepsis-associated encephalopathy: a vicious cycle of immunosuppression
Journal of Neuroinflammation, 2020 Sepsis-associated encephalopathy (SAE) is commonly complicated by septic conditions, and is responsible for increased mortality and poor outcomes in septic patients.
C. Ren +4 more
semanticscholar +1 more source