Results 51 to 60 of about 514,735 (343)

Obstetric and long-term kidney outcomes in renal transplant recipients: a 40 year single-centre study [PDF]

, 2016
Female renal transplant recipients of childbearing age may ask what the outcomes are for pregnancy and whether pregnancy will affect graft function. We analyzed obstetric and transplant outcomes among renal transplant recipients in our center who have ...
Brennand, Janet E., Deighan, Christopher J., Geddes, Colin C., Gorrie, Morag, Mark, Patrick B., McNeill, Susan H., Stoumpos, Sokratis   +6 more
core   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Alemtuzumab pre-conditioning with tacrolimus monotherapy in pediatric renal transplantation [PDF]

, 2007
We employed antibody pre-conditioning with alemtuzumab and posttransplant immunosuppression with low-dose tacrolimus monotherapy in 26 consecutive pediatric kidney transplant recipients between January 2004 and December 2005. Mean recipient age was 10.7 ±
Basu, A, Ellis, D, Erkan, E, Gray, EA, Grosso, MJ, James, G, Kayler, LK, Marcos, A, McFeaters, CG, Moritz, ML, Shapiro, R, Starzl, TE, Tan, HP, Vats, AN, Zeevi, A   +14 more
core   +1 more source

The new immunosuppression

Current Opinion in Chemical Biology, 2003
New knowledge on how lymphocytes become tolerant to antigens is now enabling novel tolerance-harnessing strategies to enter the clinical arena. In the field of transplantation, monoclonal antibodies used either to deplete lymphocytes or to block T-cell function can induce tolerance in mice and non-human primates. Understanding the mechanisms underlying
openaire   +3 more sources

Blocking Triggering Receptor Expressed on Myeloid Cells‐1‐Positive Tumor‐Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti‐Programmed Cell Death Ligand 1 Resistance in Liver Cancer

Hepatology, 2019
Tumor‐associated macrophages (TAMs) are recognized as antitumor suppressors, but how TAMs behave in the hypoxic environment of hepatocellular carcinoma (HCC) remains unclear.
Qinchuan Wu, Wu-hua Zhou, Shengyong Yin, Yuan Zhou, Tianchi Chen, Junjie Qian, Rong Su, Liangjie Hong, Haohao Lu, Feng Zhang, Haiyang Xie, Lin Zhou, Shusen Zheng   +12 more
semanticscholar   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Current status of intestinal transplantation in children [PDF]

, 1998
Purpose: A clinical trial of intestinal transplantation (Itx) under tacrolimus and prednisone immunosuppression was initiated in June 1990 in children with irreversible intestinal failure and who were dependent on total parenteral nutrition (TPN ...
Asfar, Billingham, Casavilla, Deltz, Edward M Barksdale, Fontes, Furukawa, Garau, Goulet, Grant, Grant, Grant, Green, Hiro Furukawa, Iwaki, Javier Bueno, John J Fung, Jorge Reyes, Kareem Abu-Elmagd, Kashiwagi, Langnas, Lee, Lillehei, Manez, Margreiter, McAlister, Mike Green, Monchik, Murase, Murase, Porter, Putnam, Randhawa, Rao, Reyes, Reyes, Reyes, Samuel Kocoshis, Satoru Todo, Sharon Strom, Sigurdsson, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Takaya, Thomas E Starzl, Todo, Tzakis, White, William Irish   +52 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Inflammation and immunosuppression are dominant features of cancer progression. In the tumor microenvironment, macrophages produce interleukin-1β (IL-1β), which subsequently recruits myeloid cells from the bone marrow.
Irena Kaplanov, Yaron Carmi, R. Kornetsky, A. Shemesh, G. Shurin, M. Shurin, C. Dinarello, E. Voronov, R. Apte   +8 more
semanticscholar   +1 more source

SensRORing cholesterol to drive protumoral myelopoiesis

Molecular Oncology, EarlyView.
Bleve et al. uncover a cholesterol‐driven immune evasion pathway, where RORγ‐dependent myelopoiesis shapes tumor immunosuppression. Targeting RORγ and PCSK9 emerges as a strategy to boost cancer immunotherapy. Protumoral myelopoiesis is a determinant of immunoevasion and tumor spread in many malignancies.
Sara Gennari, Luigi Nezi, Teresa Manzo
wiley   +1 more source