Results 51 to 60 of about 556,132 (392)

LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs

BMC Genomics, 2018
Background Human Endogenous Retroviruses (HERVs) and Mammalian apparent LTR-retrotransposons (MaLRs) represent the 8% of our genome and are distributed among our 46 chromosomes.
Marine Mommert, Olivier Tabone, Guy Oriol, Elisabeth Cerrato, Audrey Guichard, Magali Naville, Paola Fournier, Jean-Nicolas Volff, Alexandre Pachot, Guillaume Monneret, Fabienne Venet, Karen Brengel-Pesce, Julien Textoris, François Mallet   +13 more
doaj   +1 more source

Mechanisms underlying immunosuppression by regulatory cells

Frontiers in Immunology
Regulatory cells, such as regulatory T cells (Tregs), regulatory B cells (Bregs), and myeloid-derived suppressor cells (MDSCs), play a crucial role in preserving immune tolerance and controlling immune responses during infections to prevent excessive ...
O. Goldmann, Obiageli Vivian Nwofor, Qian Chen, Eva Medina   +3 more
semanticscholar   +1 more source

Evaluation of early and late presentation of patients with ocular mucous membrane pemphigoid to two major tertiary referral hospitals in the United Kingdom [PDF]

, 2011
PURPOSE: Ocular mucous membrane pemphigoid (OcMMP) is a sight-threatening autoimmune disease in which referral to specialists units for further management is a common practise.
AH Ross, BA Rice, BJ Mondino, BJ Mondino, C Radford, CS Foster, CS Foster, CS Yee, D Gladman, E Daniel, E Miserocchi, EH Sacks, G P Williams, GP Williams, H John, J K G Dart, J Risser, J Sheppard, J Tauber, J Tauber, J Tauber, JA Taverna, JE Thorne, JE Thorne, LS Chan, LS Chan, M Ahmed, MJ Canizares, MJ Elder, MJ Elder, MJ Elder, MJ Elder, MP Heffernan, P Nightingale, RJ Barry, RS Rogers III, S Rauz, S Rauz, S Segura, SJ Bowman, VP Saw, VP Saw, W Bernauer, W Bernauer, W Bernauer, W Bernauer   +45 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

JCI Insight, 2020
COVID-19–associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained viral ...
Kenneth E. Remy, M. Mazer, David A. Striker, A. Ellebedy, A. Walton, J. Unsinger, T. Blood, P. Mudd, Daehan J. Yi, Daniel Mannion, D. Osborne, R. S. Martin, Nitin J. Anand, James P. Bosanquet, J. Blood, A. Drewry, C. Caldwell, Isaiah R. Turnbull, S. Brakenridge, Lyle L. Moldwawer, R. Hotchkiss   +20 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Tacrolimus in pediatric renal transplantation [PDF]

, 1996
Tacrolimus was used as the primary immunosuppressive agent in 69 pediatric renal transplantations between December 17, 1989, and June 30, 1995. Children undergoing concomitant or prior liver and/or intestinal transplantation were excluded from analysis ...
Ellis, D, Fung, JJ, Gilboa, N, Gritsch, HA, Hakala, TR, Irish, W, Jordan, ML, Lombardozzi-Lane, S, Scantlebury, VP, Shapiro, R, Simmons, RL, Starzl, TE, Vivas, C   +12 more
core   +1 more source

Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

British Journal of Cancer, 2018
Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC) differentiate into granulocytes, macrophages and dendritic cells (DCs). This differentiation is impaired under chronic inflammatory conditions, which are typical for tumour ...
Christopher Groth, Xiaoying Hu, Rebekka Weber, Viktor Fleming, P. Altevogt, J. Utikal, V. Umansky   +6 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Sepsis-associated encephalopathy: a vicious cycle of immunosuppression

Journal of Neuroinflammation, 2020
Sepsis-associated encephalopathy (SAE) is commonly complicated by septic conditions, and is responsible for increased mortality and poor outcomes in septic patients.
C. Ren, R. Yao, Hui Zhang, Yong-wen Feng, Yong-ming Yao   +4 more
semanticscholar   +1 more source