Results 51 to 60 of about 392,479 (342)

Immunosuppression and Liver Transplantation

Engineering, 2023
Perfect surgical techniques and adequate immunosuppression are key to ensuring optimal graft and patient survival. The availability of different drugs has led to several, often industry-driven, heterogeneous clinical trials to discover an ideal ...
Jan Lerut, Samuele Iesari
doaj   +1 more source

Sepsis-associated encephalopathy: a vicious cycle of immunosuppression

Journal of Neuroinflammation, 2020
Sepsis-associated encephalopathy (SAE) is commonly complicated by septic conditions, and is responsible for increased mortality and poor outcomes in septic patients.
C. Ren, R. Yao, Hui Zhang, Yong-wen Feng, Yong-ming Yao   +4 more
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Immunosuppressive Agents and Infectious Risk in Transplantation: Managing the "Net State of Immunosuppression".

Clinical Infectious Diseases, 2020
Successful solid organ transplantation reflects meticulous attention to the details of immunosuppression, balancing risks for graft rejection against risks for infection.
M. B. Roberts, J. Fishman
semanticscholar   +1 more source

Lactate: The Mediator of Metabolism and Immunosuppression

Frontiers in Endocrinology, 2022
The Warburg effect, one of the hallmarks of tumors, produces large amounts of lactate and generates an acidic tumor microenvironment via using glucose for glycolysis.
Yuanyuan Zhang, Zhaoxin Zhai, J. Duan, Xiangcai Wang, Jinghua Zhong, Longqiu Wu, An Li, Miao Cao, Yanyang Wu, Huaqiu Shi, Jianing Zhong, Zhenli Guo   +11 more
semanticscholar   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine

Frontiers in Immunology, 2018
The immune response is a dynamic system that maintains the integrity of the body, and more specifically fight against infections. However, an unbalanced host immune response is highlighted in many diseases.
Chloé Albert-Vega, Dina M. Tawfik, Dina M. Tawfik, Sophie Trouillet-Assant, Sophie Trouillet-Assant, Laurence Vachot, François Mallet, François Mallet, Julien Textoris, Julien Textoris   +9 more
doaj   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song, Yi Ju, Hongqiu Gu, Zhikai Zhu, Zixiao Li, Qian Zhang, Xingquan Zhao   +6 more
wiley   +1 more source

Androgen-Induced Immunosuppression

Frontiers in Immunology, 2018
In addition to determining biological sex, sex hormones are known to influence health and disease via regulation of immune cell activities and modulation of target-organ susceptibility to immune-mediated damage.
Melanie R. Gubbels Bupp, Trine N. Jorgensen   +1 more
doaj   +1 more source

Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree. [PDF]

PLoS ONE, 2018
Sepsis is frequently complicated by a state of profound immunosuppression, in its extreme form known as immunoparalysis. We have studied the role of the adaptive immune system in the murine acute peritonitis model. To read out adaptive immunosuppression,
Katrin Schmoeckel, Daniel M Mrochen, Jochen Hühn, Christian Pötschke, Barbara M Bröker   +4 more
doaj   +1 more source