Results 81 to 90 of about 556,132 (392)
Supplementary Figure S3 from Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3<sup>+</sup> Cancer Cells in Locally Advanced Pancreatic Cancer [PDF]
, 2023 Yves Boucher +17 more
openalex +1 more source
Long-Term Immunosuppression Management: Opportunities and Uncertainties.
American Society of Nephrology. Clinical Journal, 2021 The long-term management of maintenance immunosuppression in kidney transplant recipients remains complex. The vast majority of patients are treated with the calcineurin inhibitor tacrolimus as the primary agent in combination with mycophenolate, with or
D. Wojciechowski, A. Wiseman
semanticscholar +1 more source
Arthritis Care &Research, EarlyView.Objective Lupus low disease activity state (LLDAS) is a validated treatment target in systemic lupus erythematosus (SLE), but limited studies have explored the role of LLDAS in lupus nephritis (LN). This study aims to investigate the frequency and predictors of LLDAS attainment and its benefit on LN relapse and renal function preservation in patients ...
Chak Kwan Cheung +6 more
wiley +1 more source
Scientific ReportsSepsis induces intense, dynamic and heterogeneous host response modulations. Despite improvement of patient management, the risk of mortality and healthcare-associated infections remains high.
Estelle Peronnet +11 more
doaj +1 more source
Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree. [PDF]
PLoS ONE, 2018 Sepsis is frequently complicated by a state of profound immunosuppression, in its extreme form known as immunoparalysis. We have studied the role of the adaptive immune system in the murine acute peritonitis model. To read out adaptive immunosuppression,
Katrin Schmoeckel +4 more
doaj +1 more source
Use of convalescent plasma in COVID‐19 patients with immunosuppression
Transfusion, 2021 In the absence of effective countermeasures, human convalescent plasma has been widely used to treat severe acute respiratory syndrome coronavirus 2, the causative agent of novel coronavirus disease 19 (COVID‐19), including among patients with innate or ...
Jonathon W. Senefeld +19 more
semanticscholar +1 more source
Arthritis Care &Research, EarlyView.Objective In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently, and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of the trajectory of a ...
Ji Soo Kim +18 more
wiley +1 more source
Assessment of sepsis-induced immunosuppression at ICU discharge and 6 months after ICU discharge
Annals of Intensive Care, 2017 Background Increase in mortality and in recurrent infections in the year following ICU discharge continues in survivors of septic shock, even after total clinical recovery from the initial septic event and its complications.
Violette Zorio +7 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer +5 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg +20 more
wiley +1 more source