Results 101 to 110 of about 27,400 (237)

Sonoselective Transfection of Glioma Endothelium

Advanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski, Catherine M. Gorick, Victoria R. Breza, Jackson Tirrell, Krishan Perumal, Katherine M. Nowak, Ji Song, Natasha D. Sheybani, Richard J. Price   +8 more
wiley   +1 more source

Liquid biopsy for companion diagnostic of cancer immunotherapeutics

, 2017
This thesis focuses on approach of using extracellular vesicles (EVs) excreted by cancer cells for liquid biopsy for companion diagnostic of cancer immunotherapeutics. EVs are small membrane vesicles derived from cells.
Mytzka, Nicolas
core   +2 more sources

493 Identification of different classes of antagonist monoclonal antibodies targeting the myeloid checkpoint CLEC-1 and their associated anti-tumoral in vivo efficacies in humanized preclinical models

Journal for ImmunoTherapy of Cancer, 2023
Vanessa Gauttier, Marion Drouin, Caroline Mary, Géraldine Teppaz, Ariane Desselle, Virginie Thépénier, Emmanuelle Wilhelm, Elise Chiffoleau, Nicolas Poirier, Isabelle Girault, Cecile Batty, Marine Malloci, Julien Taurelle, Irène Baccelli, Stéphanie Neyton, Mylène Deramé, Kevin Biteau, Marion Colonello   +17 more
doaj   +1 more source

The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness

Scientific Reports, 2018
Stiffening of the aorta is an important independent risk factor for myocardial infarction and stroke. Yet its genetics is complex and little is known about its molecular drivers.
Yasmin, Raya Al Maskari, Carmel M. McEniery, Sarah E. Cleary, Ye Li, Keith Siew, Nichola L. Figg, Ashraf W. Khir, John R. Cockcroft, Ian B. Wilkinson, Kevin M. O’Shaughnessy   +10 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

1369 CIS-demasking cytokine linker technology allows selective cytokine delivery to activated immune cells while sparing others and peripheral toxicity

Journal for ImmunoTherapy of Cancer, 2023
Caroline Mary, Géraldine Teppaz, Virginie Thépénier, Nicolas Poirier, Aurore morello, Margaux Seite, Justine Durand, Cecile Batty, Julien Taurelle, Amandine Georges   +9 more
doaj   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

1370 Anti-PD-1/IL-7v immunocytokine favors proliferation & survival of TCF1+ stem like memory T cells and a durable in vivo efficacy in monotherapy or using combinatorial strategy

Journal for ImmunoTherapy of Cancer, 2023
Caroline Mary, Géraldine Teppaz, Ariane Desselle, Virginie Thépénier, Emmanuelle Wilhelm, Nicolas Poirier, Aurore morello, Margaux Seite, Justine Durand, Isabelle Girault, Cecile Batty, Marine Malloci   +11 more
doaj   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Vaccines and immunotherapeutics for the prevention and treatment of infections with West Nile virus

, 2011
The emergence of West Nile virus (WNV) in North America in 1999 as a cause of severe neurological disease in humans, horses and birds stimulated development of vaccines for human and veterinary use, as well as polyclonal/monoclonal antibodies and other ...
David WC Beasley
core   +1 more source