Results 81 to 90 of about 27,400 (237)

Immunotherapeutics at the spearhead: current status in targeting neuroendocrine neoplasms

, 2021
Purpose: Recent advances in the field of immunotherapy have significantly prolonged the survival of patients with aggressive carcinomas, but the role of immunotherapy in neuroendocrine neoplasms (NENs) remains to be elucidated.
Koumarianou, A., Kaltsas, G.A., Chatzellis, E., Kyriakopoulos, G., Kolomodi, D., Alexandraki, K.I.   +5 more
core   +1 more source

Artificial intelligence-, organoid-, and organ-on-chip-powered models to improve pre-clinical animal testing of vaccines and immunotherapeutics: potential, progress, and challenges

Frontiers in Artificial Intelligence
Vaccines and immunotherapies against infectious diseases and cancers have been a great success of the medical sciences over the last century.
Elhoucine Elfatimi, Yassir Lekbach, Swayam Prakash, Sweta Karan, Joshua Christian Dorotta, America Garcia, Beverly Sabathini Suoth, Chhaya Maurya, Etinosa Yvette Omorogieva, Sarah Xue Le Ng, Emma Jane Liao, Reilly Andrew Chow, Lbachir BenMohamed, Lbachir BenMohamed, Lbachir BenMohamed, Lbachir BenMohamed   +15 more
doaj   +1 more source

Trends in all-cause pneumonia and otitis media in children aged <2 years following pneumococcal conjugate vaccine introduction in Colombia

, 2020
In Colombia, pneumococcal conjugate vaccines (PCVs) were implemented into the infant universal mass vaccination program in a stepwise manner; PCV-7 between 2009 and 2011 in different geographic regions/cities, with nationwide introduction of a 10-valent ...
DeAntonio, Rodrigo, Juliao, Patricia, Maria M. Castrejon, Rodrigo DeAntonio, Talarico, Carla, Carrasquilla, Gabriel, Gabriel Carrasquilla, Patricia Juliao, Devadiga, Raghavendra, Martinez, Sandra, Raghavendra Devadiga, Diana C. Caceres, Sandra Martinez, Alexandra Porras-Ramírez, Porras Ramírez, Alexandra, Caceres, Diana C., Carla Talarico, Castrejon, Maria M.   +17 more
core   +1 more source

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

OPTIMIZATION AND VALIDATION OF IMMUNOHISTOCHEMICAL ASSAYS FOR THE DETECTION OF TREM2 AND EVALUATION BY IMAGE ANALYSIS IN FFPE HUMAN TISSUE

Journal of Pathology Informatics, 2022
Ranna Mehta, Linnea Haeggblom, Hanna Ramoth, Mikhail Binneweis, Joshua Pollack, Josh Rudolph, Sriram Venkataraman, Xiaoyan Du, Linda Liang, Leonard Reyno, Kevin P. Baker, Nadine Jahchan   +11 more
doaj   +1 more source

Immunotherapeutics & vaccine adjuvants for cancer

, 2013
THESIS 10109It is well established that innate immune responses not only mediate immunity to infection, but also promotes adaptive immunity to pathogens and tumours.
Corcoran, Anna-Maria B.
core  

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source

The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study

Frontiers in Immunology
IntroductionMurine tumor growth restriction by neem leaf glycoprotein (NLGP) was established in various transplanted models of murine sarcoma, melanoma and carcinoma.
Juhina Das, Saurav Bera, Nilanjan Ganguly, Ipsita Guha, Tithi Ghosh Halder, Avishek Bhuniya, Partha Nandi, Mohona Chakravarti, Sukanya Dhar, Anirban Sarkar, Tapasi Das, Saptak Banerjee, Sandip Ghose, Anamika Bose, Anamika Bose, Rathindranath Baral   +15 more
doaj   +1 more source

Long survival after neoadjuvant and adjuvant camrelizumab plus chemotherapy and surgery in a patient with hepatoid adenocarcinoma of the lung: A case report

Human Vaccines & Immunotherapeutics
Hepatoid adenocarcinoma of the lung (HAL) is a rare and aggressive subtype of lung cancer. The prognosis for patients with HAL is generally poor and currently, there are only limited treatment options.
Xuhua Huang, Linhai Zhu, Weifeng Pan, Jian Hu   +3 more
doaj   +1 more source