Results 31 to 40 of about 27,400 (237)

Perspectives on the use and risk of adverse events associated with cytokine-storm targeting antibodies and challenges associated with development of novel monoclonal antibodies for the treatment of COVID-19 clinical cases

Human Vaccines & Immunotherapeutics, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the novel coronavirus disease 2019 (COVID-19) pandemic that lacks globally accessible effective antivirals or extensively available vaccines.
Aishwarya Mary Johnson, Robert Barigye, Hariharan Saminathan   +2 more
doaj   +1 more source

Immunotherapy Using Immunogenic Mimotopes Selected by Phage Display plus Amphotericin B Inducing a Therapeutic Response in Mice Infected with Leishmania amazonensis

Pathogens, 2023
Leishmania amazonensis can cause cutaneous and visceral clinical manifestations of leishmaniasis in infected hosts. Once the treatment against disease is toxic, presents high cost, and/or there is the emergence of parasite-resistant strains, alternative ...
Tauane G. Soyer, Fernanda F. Ramos, Isabela A. G. Pereira, Daniela P. Lage, Raquel S. Bandeira, Marcelo M. de Jesus, Guilherme P. Costa, Amanda S. Machado, Camila S. Freitas, Danniele L. Vale, Vívian T. Martins, Alexsandro S. Galdino, Miguel A. Chávez-Fumagalli, Daniel Menezes-Souza, Mariana C. Duarte, Bruno M. Roatt, Eduardo A. F. Coelho, Grasiele S. V. Tavares   +17 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Three Models of Vaccination Strategies Against Cryptococcosis in Immunocompromised Hosts Using Heat-Killed Cryptococcus neoformans Δsgl1

Frontiers in Immunology, 2022
Vaccines are one of the greatest medical accomplishments to date, yet no fungal vaccines are currently available in humans mainly because opportunistic mycoses generally occur during immunodeficiencies necessary for vaccine protection.
Tyler G. Normile, Maurizio Del Poeta, Maurizio Del Poeta, Maurizio Del Poeta   +3 more
doaj   +1 more source

Conference Scene: Phacilitate Barcelona Active Immunotherapeutics Forum

, 2011
The era of active immunotherapy has now been successfully ushered into the clinical realm of advanced prostate cancer. The successful clinical trial development and US FDA approval of sipuleucel-T (Provenge®) has revamped the therapeutic paradigm for ...
Neal D Shore
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Current and Novel Approaches in Influenza Management

Vaccines, 2019
Influenza is a disease that poses a significant health burden worldwide. Vaccination is the best way to prevent influenza virus infections. However, conventional vaccines are only effective for a short period of time due to the propensity of influenza ...
Erasmus Kotey, Deimante Lukosaityte, Osbourne Quaye, William Ampofo, Gordon Awandare, Munir Iqbal   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Preventing Surgery-Induced NK Cell Dysfunction Using Anti-TGF-β Immunotherapeutics

, 2022
Natural Killer (NK) cell cytotoxicity and interferon-gamma (IFNγ) production are profoundly suppressed postoperatively. This dysfunction is associated with increased morbidity and cancer recurrence.
Barbara C. Vanderhyden, David P. Cook, Juliana Ng, Cook, David P., Ng, Juliana, Vanderhyden, Barbara C., Michael A. Kennedy, Christiano Tanese de Souza, Gayashan Tennakoon, Kennedy, Michael A., Leonard Angka, Scaffidi, Marlena, Auer, Rebecca C., Rebecca C. Auer, Tanese de Souza, Christiano, Marisa Market, Marlena Scaffidi, Angka, Leonard, Market, Marisa, Tennakoon, Gayashan   +19 more
core   +1 more source