Results 21 to 30 of about 27,400 (237)

Global scenario, public health concerns and mitigation strategies to counter current ongoing SARS-CoV-2 / COVID-19 pandemic

Human Vaccines & Immunotherapeutics, 2020
Severe acute respiratory syndrome Coronavirus- 2 (SARS-CoV-2), the etiological agent of the novel coronavirus disease (COVID-19), has posed a great public health threat to the global community as a pandemic.
Sukhadeo Baliram Barbuddhe, Deepak Bhiwa Rawool, Pankaj Prakash Gaonkar, Jess Vergis, Kuldeep Dhama, Satyaveer Singh Malik   +5 more
doaj   +1 more source

Identification of novel inhibitors against hantaviruses through 2D fingerprinting and molecular modeling approaches

Frontiers in Immunology, 2023
With the immensely growing outbreaks of hantavirus with still no effective treatment available, there is an urgent need of exploring new computational approaches which will target potential virulent proteins that will eventually reduce its growth.
Abdulrahman Alshammari
doaj   +1 more source

Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus

Journal of Biomedical Science
Background Infections with Herpes simplex virus (HSV)-1 or -2 usually present as mild chronic recurrent disease, however in rare cases can result in life-threatening conditions with a large spectrum of pathology.
Narges Seyfizadeh, David Kalbermatter, Thomas Imhof, Moritz Ries, Christian Müller, Leonie Jenner, Elisabeth Blumenschein, Alexandra Yendrzheyevskiy, Frank Grün, Kevin Moog, Daniel Eckert, Ronja Engel, Philipp Diebolder, Mohamed Chami, Jürgen Krauss, Torsten Schaller, Michaela Arndt   +16 more
doaj   +1 more source

Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions

Frontiers in Neuroscience, 2023
The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB).
Alexandra Melloni, Alexandra Melloni, Longsha Liu, Longsha Liu, Vivek Kashinath, Reza Abdi, Khalid Shah, Khalid Shah, Khalid Shah   +8 more
doaj   +1 more source

Immunotherapeutics for breast cancer

, 2013
PURPOSE OF REVIEW: We review recent advances leading to a new understanding of immunology of breast cancer with its potential clinical applications. RECENT FINDINGS: With the exception of antibody-based HER2 targeting, immunotherapy in breast cancer has ...
G. Curigliano, C. Criscitiello
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Reproducibility of compartmental modelling of 18F-FDG PET/CT to evaluate lung inflammation

EJNMMI Physics, 2019
Introduction Compartmental modelling is an established method of quantifying 18F-FDG uptake; however, only recently has it been applied to evaluate pulmonary inflammation. Implementation of compartmental models remains challenging in the lung, partly due
Laurence D. Vass, Sarah Lee, Frederick J. Wilson, Marie Fisk, Joseph Cheriyan, Ian Wilkinson   +5 more
doaj   +1 more source

Host-parasite interactions during Plasmodium infection: Implications for immunotherapies

Frontiers in Immunology, 2023
Malaria is a global infectious disease that remains a leading cause of morbidity and mortality in the developing world. Multiple environmental and host and parasite factors govern the clinical outcomes of malaria.
Pankaj Chandley, Ravikant Ranjan, Sudhir Kumar, Soma Rohatgi   +3 more
doaj   +1 more source

Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics

, 2020
The advent of immunotherapy is a game changer in cancer therapy with monoclonal antibody- and T cell-based therapeutics being the current flagships. Small molecule immunotherapeutics might offer advantages over the biological drugs in terms of complexity,
De Geest, Bruno, Van Herck, Simon
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source