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Artificial intelligence and machine learning in the development of vaccines and immunotherapeutics—yesterday, today, and tomorrow [PDF]
Frontiers in Artificial IntelligenceThe development of vaccines and immunotherapies against infectious diseases and cancers has been one of the significant achievements of medical science in the last century.
Lbachir Benmohamed, Swayam Prakash
exaly +4 more sources
COVID-19: benefits and risks of passive immunotherapeutics
Human Vaccines and Immunotherapeutics, 2020 Passive immunotherapeutics (PITs), including convalescent plasma, serum, or hyperimmune immunoglobulin, have been of clinical importance during sudden outbreaks since the early twentieth century for the treatment of viral diseases such as severe acute ...
Kuldeep Dhama +2 more
exaly +3 more sources
Preclinical Development of ARV-2001, an Intradermally Administered mRNA–Lipid Nanoparticle Immunotherapeutic for the Treatment of HPV-16-Positive Cervical High-Grade Squamous Intraepithelial Lesions [PDF]
VaccinesBackground/Objective: Persistent infection with human papillomavirus type 16 (HPV-16) is the principal cause of cervical high-grade squamous intraepithelial lesions (cHSIL) and cervical cancer, yet the established treatments remain limited to ablative or
Zhengxiang He +5 more
doaj +2 more sources
Extracellular vesicle‐based vaccines and immunotherapeutics for treatment of cancer
Interdisciplinary MedicineIn recent years, cancer immunotherapy has gained substantial momentum, particularly in the field of vaccines and immunotherapeutics. Among these advancements, extracellular vesicles (EVs) have emerged as a promising cell‐free vaccine system due to their ...
Haonan Xing, Yuanyu Huang, Mei Lu
exaly +2 more sources
Targeting TREM2 on tumor-associated macrophages enhances immunotherapy
Cell Reports, 2021 Summary: Converting checkpoint inhibitor (CPI)-resistant individuals to being responsive requires identifying suppressive mechanisms. We identify TREM2+ tumor-associated macrophages (TAMs) as being correlated with exhausted CD8+ tumor-infiltrating ...
Mikhail Binnewies +22 more
doaj +1 more source
Frontiers in Immunology, 2021 Tuberculosis (TB) is a significant and continuing problem worldwide, with a death toll of around 1.5 million human lives annually. BCG, the only vaccine against TB, offers a varied degree of protection among human subjects in different regions and races ...
Faraz Ahmad +7 more
doaj +1 more source
Dermatologica Sinica, 2021 This article aims to present current COVID-19 vaccination considerations for patients on immunotherapeutics for the management of immune-mediated dermatological diseases and summarize the recommendations relevant to clinical practice in Taiwan.
Chih-Hung Lee +2 more
doaj +1 more source
Epigenetics and immune cells in medulloblastoma
Frontiers in Genetics, 2023 Medulloblastoma (MB) is a highly malignant childhood tumor of the cerebellum. Transcriptional and epigenetic signatures have classified MB into four molecular subgroups, further stratified into biologically different subtypes with distinct somatic copy ...
Francesca Gorini +8 more
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Localized and Systemic Immune Response in Human Reproductive Tract
Frontiers in Cellular and Infection Microbiology, 2021 Sexually transmitted infections (STIs) are one of the significant causes of morbidity and mortality among adolescents and adults across the globe and encompass all the infections transmitted via person-to-person sexual contact. In spite of the widespread
Rajendra Gudisa +3 more
doaj +1 more source
Journal of Interventional Cardiology, 2022 Objective. Coronary microvascular dysfunction (CMD) can complicate successful percutaneous coronary intervention (PCI). The potent endogenous vasoconstrictor peptide Endothelin-1 (ET-1) may be an important mediator.
George R. Abraham +5 more
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