Results 41 to 50 of about 156,654 (268)

Active Specific Immunotherapy in the Management of Adenocarcinoma of the Pancreas

Canadian Journal of Gastroenterology, 1995
Active specific immunotherapy for pancreatic adenocarcinoma and subsequent immunohistochemical analysis of tumour tissue have not been previously reported. To date, the therapy of pancreatic adenocarcinoma has been largely unsuccessful. A patient treated
BR Yacyshyn, BM Longenecker, WA Biermann, D McClure, S Poppema, MB Bowen-Yacyshyn   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Suppressing immunotherapy by organ-specific tumor microenvironments: what is in the brain?

Cell & Bioscience, 2019
Recent breakthroughs in cancer immunotherapy have led to curative efficacy and significantly prolonged survival in a subset of patients of multiple cancer types; and immunotherapy has become the newest pillar of cancer treatment in addition to surgery ...
Chenyu Zhang, Dihua Yu
doaj   +1 more source

Active and Passive Immunotherapy for Neurodegenerative Disorders [PDF]

Annual Review of Neuroscience, 2008
Immunotherapeutic strategies to combat neurodegenerative disorders have galvanized the scientific community since the first dramatic successes in mouse models recreating aspects of Alzheimer disease (AD) were reported. However, initial human trials of active amyloid-beta (Aβ) vaccination were halted early because of a serious safety issue ...
David L, Brody, David M, Holtzman
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Adjuvant chemotherapy does not benefit patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy

Radiation Oncology, 2018
Background The aim of the present study was to assess the efficacy of adjuvant chemotherapy (AC) in patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT).
Mingqiu Chen, Minmin Shen, Yu Lin, Pingping Liu, Xiaohong Liu, Xiqing Li, Anchuan Li, Rongqiang Yang, Wei Ni, Xin Zhou, Lurong Zhang, Benhua Xu, Jianhua Lin, Junqiang Chen, Ye Tian   +14 more
doaj   +1 more source

Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
As knowledge of Alzheimer's disease (AD) progression improves, the field has recognized the need to diversify the pipeline, broaden strategies and approaches to therapies, as well as delivery mechanisms.
Stacie Weninger, Bjorn Sperling, Robert Alexander, Magnus Ivarsson, Fiona M. Menzies, Peter Powchik, Christopher J. Weber, C. Anthony Altar, Ronald G. Crystal, Stephen J. Haggarty, Jeanne Loring, Lisa J. Bain, Maria C. Carrillo   +12 more
doaj   +1 more source

Research Advances of Traditional Chinese Medicine in Cancer Immunotherapy

Chinese Medicine and Culture, 2020
Tumorigenesis are closely associated with the immune function of the human body. Immunotherapy has emerged as a novel and promising treatment strategy in multiple malignancies in the 21st century.
Jing Li, Shengqi Wang, Neng Wang, Zhiyu Wang   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source