Special issue: Ribosome-inactivating proteins : commemorative issue in honor of Professor Fiorenzo Stirpe [PDF]
, 2017 The family of ribosome-inactivating proteins (RIPs) groups all enzymes (EC.3.2.2.22) with a so-called RIP domain which comprises N-glycosidase activity and enables these proteins to catalytically inactivate ribosomes.[...
Van Damme, Els
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Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A
Toxins, 2016 Recombinant immunotoxins (RITs) are fusions of an Fv-based targeting moiety and a toxin. Pseudomonas exotoxin A (PE) has been used to make several immunotoxins that have been evaluated in clinical trials.
Gilad Kaplan +6 more
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Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation. [PDF]
, 2015 Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes.
Adigbli +69 more
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Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview
Biomedicines, 2016 Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or an antibody fragment. Conjugation can be obtained by chemical or genetic engineering, where the latter yields recombinant conjugates.
Letizia Polito +2 more
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Toxins, 2022 Saporin is a ribosome-inactivating protein that can cause inhibition of protein synthesis and causes cell death when delivered inside a cell. Development of commercial Saporin results in a technology termed ‘molecular surgery’, with Saporin as the ...
Leonardo R. Ancheta +4 more
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Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. [PDF]
, 2017 INTRODUCTION: Colorectal cancer remains the second leading cause of cancer death in the United States, and new strategies to prevent, detect, and treat the disease are needed.
Aka, Allison A. +5 more
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Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells [PDF]
, 2017 Immunotoxins as antiviral therapeutics are largely unexplored but have promising prospective due to their high selectivity potential and their unparalleled efficiency.
Jeppesen, Mads G. +5 more
core +5 more sources
Immunotoxin: A new tool for cancer therapy
Tumor Biology, 2017 Cancer is one of the main reasons of death in the most countries and in Iran. Immunotherapy quickly became one of the best methods of cancer treatment, along with chemotherapy and radiation. “Immunotoxin Therapy” is a promising way of cancer therapy that
Hossein Allahyari +4 more
doaj +1 more source
B‐cell receptors of EBV‐negative Burkitt lymphoma bind modified isoforms of autoantigens
eJHaem, 2022 Burkitt lymphoma (BL) represents the most aggressive B‐cell‐lymphoma. Beside the hallmark of IG‐MYC‐translocation, surface B‐cell receptor (BCR) is expressed, and mutations in the BCR pathway are frequent.
Theresa Bock +24 more
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GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer. [PDF]
, 2014 The emergence of targeted cancer therapy has been limited by the paucity of determinants which are tumor-specific and generally associated with disease, and have cell dynamics which effectively deploy cytotoxic payloads.
Berman-Booty, Lisa D +5 more
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