Results 41 to 50 of about 4,121 (170)
British Journal of Pharmacology, EarlyView.Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid +9 more
wiley +1 more source
Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer
MedComm, Volume 7, Issue 10, October 2026.Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta +2 more
wiley +1 more source
Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms
Bioengineering, 2023 Recent advances in targeted cancer therapy hold great promise for both research and clinical applications and push the boundaries in finding new treatments for various currently incurable cancers.
Linxiang Yin, Hatim Thaker
doaj +1 more source
Cancer Immunotherapy and the Immune Response in Hodgkin Lymphoma
Frontiers in Oncology, 2018 Patients with classical Hodgkin lymphoma (cHL) have an impaired cellular immune response as indicated by an anergic reaction against standard recall antigens and a diminished rejection reaction of allogeneic skin transplant. This clinical observation can
Christoph Renner, Frank Stenner
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Under normal conditions, Notch2 promotes Nrf2 transcription by forming a transcriptional activation complex, which is crucial for maintaining the antioxidant capacity of human dopamine‐like neural cells. In pathological conditions, increased DTX2 expression has been shown to mediate Notch2 ubiquitination and subsequent degradation, leading to reduced ...
Qibin Zheng +7 more
wiley +1 more source
Reviews in Aquaculture, Volume 18, Issue 4, September 2026.ABSTRACT Microalgae are promising platforms for producing diverse biocompounds relevant to multiple commercial sectors, and the use of genomic technologies in microalgae is rapidly expanding. To examine the research trends, we conducted a bibliographic analysis (systematic map) of this rapidly developing field. Our study presents a descriptive overview
Irene Gallego +2 more
wiley +1 more source
Actinomycin Derivatives: Structural Diversification and Biological Activities
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley +1 more source
The future of antiviral immunotoxins [PDF]
Journal of Leukocyte Biology, 2016 Abstract There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments. Immunotoxins have been extensively explored in cancer treatment and have achieved FDA approval in several cases. Indeed, the design
Spiess, Katja +3 more
openaire +3 more sources
Immunity, Inflammation and Disease, Volume 14, Issue 7, July 2026.ABSTRACT Background Immune checkpoint inhibitors (ICIs) targeting the PD‐1/PD‐L1 pathway have revolutionized cancer immunotherapy, yet their clinical benefit is constrained by variable response rates and immune‐related adverse events. Aims This review systematically analyzes the molecular mechanisms by which key gut microbiota‐derived metabolites ...
Xuanyou Fang, Shuai Yuan, Weijian Mai
wiley +1 more source
Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies
Biomedicines, 2017 Protein-based targeted toxins play an increasingly important role in targeted tumor therapies. In spite of their high intrinsic toxicity, their efficacy in animal models is low.
Hendrik Fuchs +6 more
doaj +1 more source