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Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview
Biomedicines, 2016 Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or an antibody fragment. Conjugation can be obtained by chemical or genetic engineering, where the latter yields recombinant conjugates.
Letizia Polito +2 more
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Toxins, 2022 Saporin is a ribosome-inactivating protein that can cause inhibition of protein synthesis and causes cell death when delivered inside a cell. Development of commercial Saporin results in a technology termed ‘molecular surgery’, with Saporin as the ...
Leonardo R. Ancheta +4 more
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Treatment with immunotoxin [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 T–cell depletion prior to or beginning at the time of transplantation has been shown to be a valuable adjunct to the induction of immunological unresponsiveness. Both total lymphoid irradiation and anti–lymphocyte globulin have been used for this purpose in experimental models of transplantation as well as in human organ transplant recipients. However,
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Immunotoxin: A new tool for cancer therapy
Tumor Biology, 2017 Cancer is one of the main reasons of death in the most countries and in Iran. Immunotherapy quickly became one of the best methods of cancer treatment, along with chemotherapy and radiation. “Immunotoxin Therapy” is a promising way of cancer therapy that
Hossein Allahyari +4 more
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B‐cell receptors of EBV‐negative Burkitt lymphoma bind modified isoforms of autoantigens
eJHaem, 2022 Burkitt lymphoma (BL) represents the most aggressive B‐cell‐lymphoma. Beside the hallmark of IG‐MYC‐translocation, surface B‐cell receptor (BCR) is expressed, and mutations in the BCR pathway are frequent.
Theresa Bock +24 more
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Saporin-S6: A Useful Tool in Cancer Therapy
Toxins, 2013 Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and mechanisms of action of saporin-S6 have been well characterized, and it ...
Letizia Polito +4 more
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Antibodies, 2014 Targeted therapies for the treatment of cancer, but also inflammation and autoimmune diseases will reduce major side effects accompanied with conventional treatment modalities. The immunotoxin concept uses bacterial or plant toxins, coupled to antibodies
Nina Berges +5 more
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Antibody-Based Immunotoxins for the Treatment of Cancer
Antibodies, 2012 Antibody-based immunotoxins comprise an important group in targeted cancer therapeutics. These chimeric proteins are a form of biological guided missiles that combine a targeting moiety with a potent effector molecule.
Nurit Becker, Itai Benhar
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Immunotoxin Therapies for the Treatment of Epidermal Growth Factor Receptor-Dependent Cancers
Toxins, 2016 Many epithelial cancers rely on enhanced expression of the epidermal growth factor receptor (EGFR) to drive proliferation and survival pathways. Development of therapeutics to target EGFR signaling has been of high importance, and multiple examples have ...
Nathan Simon, David FitzGerald
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Biotherapy, 1991 Immunotoxins (ITs) are chimeric molecules constructed by covalently conjugating monoclonal antibodies (MoAbs) to plant or bacterial toxins (e.g. ricin or pseudomonas exotoxin). The antibody moiety allows specific targeting of ITs to tumor-associated antigens, while the toxin moiety is responsible for cell killing by irreversible inactivation of protein
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