Results 21 to 30 of about 7,748 (215)

Immunomagnetic t-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody [PDF]

, 1989
Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (0×19) bound to monosized,
A. Pascualone, A.L. Hoffman, B.F. Banner, Barclay A, Berenson R J, Beschorner W E, Bril H, D.G. Sheahan, D.V. Cramer, Dallman M J, Elkins W L, Farnsworth A, Filipovich A H, Kvalheim G, L. Makowka, Lubaroff D M, Martin P J, Monchik G J, Oaks M K, P. Rettinger, Prentice H G, Reisner Y, Rodt H, Slavin R E, T.E. Starzl, Thtschka P J, Tsoi M-S, Van Bekkum D W, Vartdal F, Waldman H, X. Cai   +30 more
core   +1 more source

Pseudomonas Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient’s Bedside to Evaluation in Preclinical Models

Toxins, 2019
Immunotoxins are protein drugs composed of a targeting domain genetically fused to a protein toxin. One killing domain being explored is a truncated Pseudomonas exotoxin A (PE).
Yasmin Leshem, Ira Pastan
doaj   +1 more source

The future of antiviral immunotoxins [PDF]

, 2016
There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments.
Høy Jakobsen, Mette, Kledal, Thomas N, Rosenkilde, Mette M., Spiess, K.   +3 more
core   +1 more source

Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A

Toxins, 2016
Recombinant immunotoxins (RITs) are fusions of an Fv-based targeting moiety and a toxin. Pseudomonas exotoxin A (PE) has been used to make several immunotoxins that have been evaluated in clinical trials.
Gilad Kaplan, Fred Lee, Masanori Onda, Emily Kolyvas, Gaurav Bhardwaj, David Baker, Ira Pastan   +6 more
doaj   +1 more source

Immunotoxins for leukemia

Blood, 2014
AbstractUnconjugated monoclonal antibodies that target hematopoietic differentiation antigens have been developed to treat hematologic malignancies. Although some of these have activity against chronic lymphocytic leukemia and hairy cell leukemia, in general, monoclonal antibodies have limited efficacy as single agents in the treatment of leukemia.
Alan S, Wayne, David J, Fitzgerald, Robert J, Kreitman, Ira, Pastan   +3 more
openaire   +3 more sources

Plant Toxin-Based Immunotoxins for Cancer Therapy: A Short Overview

Biomedicines, 2016
Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or an antibody fragment. Conjugation can be obtained by chemical or genetic engineering, where the latter yields recombinant conjugates.
Letizia Polito, Alice Djemil, Massimo Bortolotti   +2 more
doaj   +1 more source

Saporin as a Commercial Reagent: Its Uses and Unexpected Impacts in the Biological Sciences—Tools from the Plant Kingdom

Toxins, 2022
Saporin is a ribosome-inactivating protein that can cause inhibition of protein synthesis and causes cell death when delivered inside a cell. Development of commercial Saporin results in a technology termed ‘molecular surgery’, with Saporin as the ...
Leonardo R. Ancheta, Patrick A. Shramm, Raschel Bouajram, Denise Higgins, Douglas A. Lappi   +4 more
doaj   +1 more source

Phase I clinical study of the recombinant antibody toxin scFv(FRP5)-ETA specific for the ErbB2/HER2 receptor in patients with advanced solid malignomas [PDF]

, 2005
Introduction: ScFv(FRP5)-ETA is a recombinant antibody toxin with binding specificity for ErbB2 (HER2). It consists of an N-terminal single-chain antibody fragment (scFv), genetically linked to truncated Pseudomonas exotoxin A (ETA).
Gunter von Minckwitz, Sebastian Harder, Sascha Hövelmann, Elke Jäger, Salah-Eddin Al-Batran, Sibylle Loibl, Akin Atmaca, Christian Cimpoiasu, Antje Neumann, Aklil Abera, Alexander Knuth, Manfred Kaufmann, Dirk Jäger, Alexander B Maurer, Winfried S Wels, MA Olayioye, Y Yarden, J Mendelsohn, DJ Slamon, CL Vogel, I Pastan, W Wels, RJ Kreitman, W Wels, W Wels, IM Harwerth, BH Iglewski, A Keppler-Hafkemeyer, M Schmidt, A Spyridonidis, M Azemar, L Wang, U Altenschmidt, M Maurer-Gebhard, JK Batra, Y Reiter, LH Pai-Scherf, M Azemar, WMA, M Maurer-Gebhard, FDA, J Schumann, M Onda, NJ Olsen, YL Yip, B Gerstmayer, DL Keefe, HS Cho, RJ Kreitman, RJ Kreitman   +49 more
core   +1 more source

Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation. [PDF]

, 2015
Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes.
Adigbli, Adigbli, Arentsen, Baglo, Berg, Berg, Berg, Berg, Berstad, Bodles-Brakhop, Bostad, Bostad, Bull-Hansen, Castano, Castano, Chong, Dietze, Dietze, Elisabeth Olsen, Fretz, Gaware, Gooding, Gottesman, Hirschberg, Høgset, Jørgensen, Kunz, Lai, Lai, Lakshmanan, Lou, Lu, Lund, Mathews, Mroz, Mroz, Norum, Norum, Norum, Norum, Pasparakis, Peng, Peng, Prasmickaite, Reginato, Rosenblum, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, Selbo, St Denis, Stratford, Todorova, Vikdal, Wang, Wang, Wang, Weyergang, Weyergang, Woodhams, Xu, Yaghini, Yao, Yip, Zahreddine   +69 more
core   +1 more source

Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. [PDF]

, 2017
INTRODUCTION: Colorectal cancer remains the second leading cause of cancer death in the United States, and new strategies to prevent, detect, and treat the disease are needed.
Aka, Allison A., Pattison, Amanda M., Rappaport, Jeff A., Sato, Takami, Snook, Adam E., Waldman, Scott A.   +5 more
core   +2 more sources