Results 61 to 70 of about 3,943 (171)
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Advanced Science, Volume 13, Issue 10, 18 February 2026.Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
Antibodies, 2013 Ricin is a type II ribosome inactivating protein (RIP) isolated from castor beans. Its high toxicity classifies it as a possible biological weapon. On the other hand, ricin linked to specific monoclonal antibodies or used in other conjugates has powerful
Monika Słomińska-Wojewódzka +1 more
doaj +1 more source
The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease
BioEssays, Volume 48, Issue 2, February 2026.The meninges and synovium share multiple functional and structural characteristics and act as specialized immunological barriers. In MS and RA, both can host tertiary lymphoid organs (TLOs) and CD4+ Tph cells. We highlight how these features sustain compartmentalized inflammation and explore a possible role for EBV in their formation and persistence ...
Mohamed Reda Fazazi, Manu Rangachari
wiley +1 more source
Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins. [PDF]
PLoS ONE, 2016 The intersection of small molecular weight drugs and antibody-based therapeutics is rarely studied in large scale. Both types of agents are currently part of the cancer armamentarium.
Antonella Antignani +11 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.A novel mouse model of mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) by unilateral, partial ablation of hippocampal GABAergic neurons is established. The model recapitulates key features of the human condition, including spontaneous recurrent seizures, HS‐like pathology, and associated cognitive deficits.
Ting Tang +10 more
wiley +1 more source
Targeted Diphtheria Toxin-Based Therapy: A Review Article
Frontiers in Microbiology, 2019 Cancer remains one of the leading causes of death worldwide. Conventional therapeutic strategies usually offer limited specificity, resulting in severe side effects and toxicity to normal tissues.
Fatemeh Shafiee +2 more
doaj +1 more source
The future of antiviral immunotoxins [PDF]
Journal of Leukocyte Biology, 2016 Abstract There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments. Immunotoxins have been extensively explored in cancer treatment and have achieved FDA approval in several cases. Indeed, the design
Spiess, Katja +3 more
openaire +3 more sources
CD30 as a Target Molecule in the Diagnosis and Therapy of Lymphomas
American Journal of Hematology, Volume 101, Issue 1, Page 110-128, January 2026.ABSTRACT The tumor necrosis factor (TNF)‐receptor superfamily 8 receptor CD30 molecule is expressed in all tumor cells of Hodgkin lymphoma and anaplastic large cell lymphoma but is only weakly expressed in a small subset of large lymphoid cells in normal peripheral lymphoid tissues.
Harald Stein, Brunangelo Falini
wiley +1 more source
Immunotoxins Targeting B cell Malignancy—Progress and Problems With Immunogenicity
Biomedicines, 2018 Few immunotoxins or targeted toxins have become mainline cancer therapies. Still immunotoxins continue to be of major interest and subject of research and development as alternative therapies for drug resistant cancer. A major matter of concern continues
Daniel A. Vallera, Robert J. Kreitman
doaj +1 more source
Exploring the Role of Acrylamide in Food Allergy via Dendritic Cell‐Dependent Th2 Immune Responses
Food Frontiers, Volume 7, Issue 1, January 2026.Acrylamide may disrupt immune tolerance as a foodborne immunotoxicant, priming allergic inflammatory susceptibility through DC‐dependent Th2/Th17 polarization, TLR4/NF‐κB signaling amplification, and IL‐10 production suppression. ABSTRACT Acrylamide (AA), a prevalent food processing contaminant with recognized multi‐organ toxicity, has an unexplored ...
Xue Feng +8 more
wiley +1 more source