Results 71 to 80 of about 3,943 (171)

Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins

Toxins, 2019
Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells.
Javier Ruiz-de-la-Herrán, Jaime Tomé-Amat, Rodrigo Lázaro-Gorines, José G. Gavilanes, Javier Lacadena   +4 more
doaj   +1 more source

Comprehensive Review on the Occurrence of Aflatoxin M1 in Milk, Prevalent Health Issues Associated With It, and Innovative Strategies for Mitigation of Aflatoxin M1 in Processed Milk

Food Safety and Health, Volume 4, Issue 1, Page 67-81, January 2026.
Aflatoxins, carcinogenic compounds in milk; reduction strategies such as thermal deactivation, UV light exposure, ionizing radiation, and solvent extraction. ABSTRACT Aflatoxins (AFs) are known to be cancer causing substances recognized within milk along with the milk goods.
Akshay Ramani, Tanmay Hazra, Anamika Das, Subhadip Manik, Ayon Tarafdar, Swarnima Dey, Umesh Singh   +6 more
wiley   +1 more source

The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations

Toxins, 2017
Ribosome inactivating proteins (RIPs) form a class of toxins that was identified over a century ago. They continue to fascinate scientists and the public due to their very high activity and long-term stability which might find useful applications in the ...
Aleksander Rust, Lynda J. Partridge, Bazbek Davletov, Guillaume M. Hautbergue   +3 more
doaj   +1 more source

Rivers of Tears – Convergent, Multi‐Scale Approaches to Monitor and Optimize the Health of Our World's Inhabitants

Global Challenges, Volume 10, Issue 1, January 2026.
Probing and sustaining the health of Earth's ecosystems and their inhabitants requires convergent approaches at multiple length and time scales. Predictive computational and physical modeling, together with novel biotechnologies applied in unexpected ways, are paving the way for discoveries at the intersection of epidemiology and geospatial science ...
Eric J. Anderson, Vittorio Sansalone, Luke P. Lee, Rebecca Grainger, Sohie Lee, Albert L. Juhasz, Melissa L. Knothe Tate   +6 more
wiley   +1 more source

Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps

Journal of Applied Toxicology, Volume 46, Issue 1, Page 61-77, January 2026.
ABSTRACT Despite growing health concerns, bifenthrin (BF) remains widely used for controlling agricultural and residential pests. However, different perspectives on its toxicological profile and regulatory framework warrant a revisit and update on BF regulation towards a robust risk‐safety assessment.
Caroline V. L. Moreira, John Ogbu I, Kadja L. C. Monteiro, Thiago M. de Aquino, Edeildo F. da Silva‐Júnior, Alberto S. S. Filho, Hamilton B. Napolitano, Christianah A. Elusiyan, Renê O. do Couto, Elson A. Costa, James O. Fajemiroye   +10 more
wiley   +1 more source

SS1P Immunotoxin Induces Markers of Immunogenic Cell Death and Enhances the Effect of the CTLA-4 Blockade in AE17M Mouse Mesothelioma Tumors

Toxins, 2018
SS1P is an anti-mesothelin immunotoxin composed of a targeting antibody fragment genetically fused to a truncated fragment of Pseudomonas exotoxin A. Delayed responses reported in mesothelioma patients receiving SS1P suggest that anti-tumor immunity is ...
Yasmin Leshem, Emily M. King, Ronit Mazor, Yoram Reiter, Ira Pastan   +4 more
doaj   +1 more source

Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E

Advanced Science
Regulated necrosis is a known direct consequence of activation of the necroptosis‐ and pyroptosis‐ pathways, but may also result from apoptosis in a process referred to as secondary necrosis.
Shubhangi Gavali, Francesca Maremonti, Wulf Tonnus, Florian Gembardt, Marlena Nastassja Schlecht, Karolin Flade, Anne vonMässenhausen, Stephen W. G. Tait, Stefan R. Bornstein, Andreas Linkermann   +9 more
doaj   +1 more source

Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies

Vaccines
Effective cancer therapies must address the tumor microenvironment (TME), a complex network of tumor cells and stromal components, including endothelial, immune, and mesenchymal cells. Durable outcomes require targeting both tumor cells and the TME while
Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara   +5 more
doaj   +1 more source

T-Cell Receptor-Like Antibodies: Targeting the Intracellular Proteome Therapeutic Potential and Clinical Applications

Antibodies, 2013
Major histocompatibility complex (MHC) class I molecules are key in the immune response against malignant cells by shaping the T-cell repertoire and presenting peptides from endogenous antigens to CD8+ cytotoxic T cells.
Maya Cohen, Yoram Reiter
doaj   +1 more source

Ricin: An Ancient Story for a Timeless Plant Toxin

Toxins, 2019
The castor plant (Ricinus communis L.) has been known since time immemorial in traditional medicine in the pharmacopeia of Mediterranean and eastern ancient cultures. Moreover, it is still used in folk medicine worldwide.
Letizia Polito, Massimo Bortolotti, Maria Giulia Battelli, Giulia Calafato, Andrea Bolognesi   +4 more
doaj   +1 more source