Results 81 to 90 of about 7,748 (215)
Exploring the Role of Acrylamide in Food Allergy via Dendritic Cell‐Dependent Th2 Immune Responses
Food Frontiers, Volume 7, Issue 1, January 2026.Acrylamide may disrupt immune tolerance as a foodborne immunotoxicant, priming allergic inflammatory susceptibility through DC‐dependent Th2/Th17 polarization, TLR4/NF‐κB signaling amplification, and IL‐10 production suppression. ABSTRACT Acrylamide (AA), a prevalent food processing contaminant with recognized multi‐organ toxicity, has an unexplored ...
Xue Feng +8 more
wiley +1 more source
Targeted Diphtheria Toxin-Based Therapy: A Review Article
Frontiers in Microbiology, 2019 Cancer remains one of the leading causes of death worldwide. Conventional therapeutic strategies usually offer limited specificity, resulting in severe side effects and toxicity to normal tissues.
Fatemeh Shafiee +2 more
doaj +1 more source
Codominance and toxins: A path to drugs of nearly unlimited selectivity [PDF]
, 1995 The effectiveness of drugs is often limited by their insufficient selectivity. I propose designs of therapeutic agents that address this problem. The key feature of these reagents, termed comtoxins (codominance-mediated toxins), is their ability to ...
Varshavsky, Alexander
core
Ricin trafficking in plant and mammalian cells [PDF]
, 2011 Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike, Spooner, Robert A.
core +2 more sources
Food Safety and Health, Volume 4, Issue 1, Page 67-81, January 2026.Aflatoxins, carcinogenic compounds in milk; reduction strategies such as thermal deactivation, UV light exposure, ionizing radiation, and solvent extraction. ABSTRACT Aflatoxins (AFs) are known to be cancer causing substances recognized within milk along with the milk goods.
Akshay Ramani +6 more
wiley +1 more source
Immunotoxins Targeting B cell Malignancy—Progress and Problems With Immunogenicity
Biomedicines, 2018 Few immunotoxins or targeted toxins have become mainline cancer therapies. Still immunotoxins continue to be of major interest and subject of research and development as alternative therapies for drug resistant cancer. A major matter of concern continues
Daniel A. Vallera, Robert J. Kreitman
doaj +1 more source
Chemoresistance of renal cell carcinoma: 1986-1994 [PDF]
, 1994 Multidrug resistance (MDR) in a variety of human tumors such as renal cell carcinoma (RCC) is thought to be caused by expression of the mdr1 gene and may be reversed by applying chemosensitizers such as Dexverapamil that inhibit the mdr1 gene product P ...
Mickisch, G.H.J.
core +2 more sources
Global Challenges, Volume 10, Issue 1, January 2026.Probing and sustaining the health of Earth's ecosystems and their inhabitants requires convergent approaches at multiple length and time scales. Predictive computational and physical modeling, together with novel biotechnologies applied in unexpected ways, are paving the way for discoveries at the intersection of epidemiology and geospatial science ...
Eric J. Anderson +6 more
wiley +1 more source
Toxins, 2017 Ribosome inactivating proteins (RIPs) form a class of toxins that was identified over a century ago. They continue to fascinate scientists and the public due to their very high activity and long-term stability which might find useful applications in the ...
Aleksander Rust +3 more
doaj +1 more source
Dianthin and Its Potential in Targeted Tumor Therapies [PDF]
, 2019 Dianthin enzymes belong to ribosome-inactivating proteins (RIPs) of type 1, i.e., they only consist of a catalytic domain and do not have a cell binding moiety.
Fuchs, Hendrik
core +1 more source