Results 41 to 50 of about 1,600 (181)

Antiplatelet Activity of Coumarins: In Vitro Assays on COX-1

Molecules, 2021
Atherosclerotic cardiovascular disease is the leading cause of death in developed countries. Therefore, there is an increasing interest in developing new potent and safe antiplatelet agents.
Cristina Zaragozá, Francisco Zaragozá, Irene Gayo-Abeleira, Lucinda Villaescusa   +3 more
doaj   +1 more source

Influence of flavonoids’ lipophilicity on platelet aggregation

Acta Pharmaceutica, 2019
Flavonoids are natural polyphenolic compounds present in a wide spectrum of plants that have a beneficial effect on human health. In the context of cardiovascular diseases related to plaque and thrombus formation, flavonoids exhibit an anti-aggregatory ...
Babić Ivana, Bojić Mirza, Maleš Željan, Zadro Renata, Gojčeta Koraljka, Duka Ivan, Rimac Hrvoje, Jukić Irena   +7 more
doaj   +1 more source

Comparison of farmacodynamic properties of three different aspirin formualtions in patients with stable coronary disease [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. The platelet aggregation, as a laboratory test for assessment of platelet function, is very efficient for optimal antiplatelet treatment and also to identify individuals who have suboptimal response to antiplatelet drugs, such as aspirin ...
Antić Ana, Stanojković Zoran, Vučić Miodrag, Lazarević Milan, Vacić Nebojša   +4 more
doaj   +1 more source

Platelet Function During Extracorporeal Membrane Oxygenation in Adult Patients

Frontiers in Cardiovascular Medicine, 2019
Objective: Hemorrhagic and thromboembolic complications are common during support with extracorporeal membrane oxygenation (ECMO). As platelets play a pivotal role in hemostasis, we aimed to clarify how ECMO support affects platelet function.Methods: We ...
Camilla Mains Balle, Anni Nørgaard Jeppesen, Steffen Christensen, Anne-Mette Hvas, Anne-Mette Hvas   +4 more
doaj   +1 more source

Independent association of PCSK9 with platelet reactivity in subjects without statin or antiplatelet agents

Frontiers in Cardiovascular Medicine, 2022
Background and aimsProprotein convertase subtilisin/kexin type 9 (PCSK9) levels could predict cardiovascular event in patients with well-controlled LDL-C levels, suggesting an LDL-independent mechanism of PCSK9 on the cardiovascular system.
Shuai Wang, Di Fu, Huixing Liu, Daoquan Peng   +3 more
doaj   +1 more source

FEATURES OF PLATELET HEMOSTASIS IN PATIENTS WITH VARIOUS SENSITIVITY TO ANTIPLATELET THERAPY IN STABLE ANGINA PECTORIS AFTER PLANNED PERCUTANEOUS CORONARY INTERVENTION

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2017
Background. One of the significant problems of using double antiplatelet therapy (DATT) in patients with ischemic heart disease is the development of resistance to acetylsalicylic acid (ASA) and to clopidogrel. Purpose of the study.
Pronko T. P., Snezhitskiy V. A., Makarova E. A., Avseenko A. A., Kharitonenko Т. V.   +4 more
doaj   +1 more source

Platelet function in patients undergoing major non‐cardiac vascular surgery (PLUGS): a prospective cohort study*

Anaesthesia, EarlyView.
Summary Introduction Patients who require major vascular surgery often receive antiplatelet therapy for primary or secondary prevention of cardiovascular disease. Clopidogrel resistance and variability in platelet recovery after drug discontinuation pose clinical challenges, particularly for regional anaesthesia and blood management.
Akshay Shah, Grace Polley, Kasia Bera, Keith Maher, Stephen Von‐Kier, Antonio Barbosa, Louis Corrigan, Sabeena Sharma, Peter Baker, Stuart R. McKechnie, Michael J. Desborough, on behalf of the PLUGS Investigators   +11 more
wiley   +1 more source

Whole blood platelet aggregation determined by the ROTEM platelet equipment; reference intervals and stability

Platelets, 2020
Point of care testing of residual effect of antiplatelet therapy in trauma patients or during major surgery may result in improved clinical management of significant bleeding. We included 121 healthy individuals (57 females and 64 males, aged 22–65 years)
Peter H. Nissen, Mette Tiedemann Skipper, Anne-Mette Hvas   +2 more
doaj   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

Relationship between human platelet antigen-1 gene polymorphism and clopidogrel resistance in patients with coronary artery disease

Türk Kardiyoloji Derneği Arşivi, 2013
Objectives: It has been proposed that human platelet antigen- 1 (HPA-1) gene polymorphism is associated with coronary artery disease (CAD) and affects platelet function.
İbrahim Halil Tanboğa, Mehmet Mustafa Can, Alper Özkan, Hacer Ceren Tokgöz, Taylan Akgün, Fatih Koca, Mustafa Kurt, Cihangir Kaymaz   +7 more
doaj   +1 more source