Results 51 to 60 of about 1,600 (181)

Stent Thrombosis: A Narrative Review From Pathophysiology to Therapy

Clinical Cardiology, Volume 49, Issue 4, April 2026.
Stent thrombosis remains a life‐threatening complication of PCI driven by complex interactions between stent design, procedural factors, thrombogenic milieu, and inflammation. This review integrates pathophysiological mechanisms with contemporary and emerging therapeutic strategies, highlighting optimized PCI, tailored antithrombotic therapy, and novel
Emanuele Cecchi, Andrea Grasso Granchietti, Ruggero Mazzotta, Manuel Garofalo, Giorgia Panichella, Giuseppe Iula, Francesca Maria Di Muro, Silvia Menale, Rossella Marcucci   +8 more
wiley   +1 more source

Arachidonic acid-induced platelet aggregation and acetylsalicylic acid treatment during pregnancy in women with recurrent miscarriage, a post hoc study

Platelets, 2022
In this post hoc study, arachidonic acid (AA)-induced platelet aggregation during pregnancy with and without acetylsalicylic acid (ASA) treatment was studied in 323 women with unexplained recurrent first-trimester miscarriage and in 59 healthy women with
Lennart R. F. Blomqvist, Annika M. Strandell, Anders Jeppsson, Margareta S. E. Hellgren   +3 more
doaj   +1 more source

Synergetic hemostatic potential of fibrinogen γ‐chain peptide‐coated, adenosine 5′‐diphosphate‐encapsulated liposomes combined with whole blood transfusion: A preclinical study

Transfusion, Volume 66, Issue 2, Page 405-412, February 2026.
Abstract Background Whole blood (WB) transfusions are being reevaluated because of their high hemostatic capacity and reduced volume. Fibrinogen γ‐chain peptide‐coated, adenosine 5′‐diphosphate (ADP)‐encapsulated liposomes are potent hemostatic adjuvants promoting platelet thrombi formation.
Osamu Ishida, Kohsuke Hagisawa, Nozomu Yamanaka, Makoto Aoki, Koji Tsutsumi, Shinji Takeoka, Manabu Kinoshita   +6 more
wiley   +1 more source

Platelet aggregation in healthy women during normal pregnancy - a longitudinal study

Platelets, 2019
Increased platelet activation is involved in obstetric complications such as preeclampsia and intrauterine growth retardation. It is of interest to study platelet aggregation during pregnancy, since increased aggregation theoretically could be a ...
Lennart Rune Fredrik Blomqvist, Annika Margareta Strandell, Fariba Baghaei, Margareta Sofia Elisabet Hellgren   +3 more
doaj   +1 more source

Platelet consumption and hyperreactivity coexist in experimental traumatic hemorrhagic model

Platelets, 2020
Introduction Platelets are critical for hemostasis, and a low platelet count predicts mortality in trauma. The role of platelet dysfunction in severe traumatic hemorrhage and coagulopathy needs to be further defined. The aim of this study was to evaluate
Marcus Wannberg, Xinyan Miao, Nailin Li, Agneta Wikman, Carl-Magnus Wahlgren   +4 more
doaj   +1 more source

Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa, Anne‐Katrin Rohlfing, Ravi Hochuli, Pamela Weronika Sowa, Tatsiana Castor, Meinrad Paul Gawaz   +5 more
wiley   +1 more source

In vitro effect of blood cell counts on multiple-electrode impedance aggregometry in dogs

American Journal of Veterinary Research, 2017
Abstract OBJECTIVE To assess the effect of decreased platelet and WBC counts on platelet aggregation as measured by a multiple-electrode impedance aggregometer in dogs. ANIMALS 24 healthy dogs. PROCEDURES From each dog, 9 mL of blood was collected into a 10-mL syringe that contained 1 mL of 4% sodium citrate solution to yield a 10-mL sample with a 1:9 ...
Nash, Katherine J., Bacek, Lenore M., Christopherson, Pete W., Spangler, Elizabeth A.   +3 more
openaire   +4 more sources

Isoquercetin and Zafirlukast Cooperatively Suppress Tumor Growth and Thromboinflammatory Signaling in a Xenograft Model of Ovarian Cancer

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Treatment using either the thiol isomerase inhibitor isoquercetin or zafirlukast lowers tissue factor levels, decreases VEGF, inhibits PD‐L1, and TMEM176B in a xenograft model of ovarian cancer. A combination of the two agents, at threefold lower concentrations than either drug, significantly enhanced the inhibition further, suggesting a dual action of
Justine A. Keovilay, Jason W. Hoskins, Jean‐Pierre Kinet, Thomas C. Lines, Daniel R. Kennedy   +4 more
wiley   +1 more source

Serotonin antagonism improves platelet inhibition in clopidogrel low-responders after coronary stent placement: an in vitro pilot study. [PDF]

PLoS ONE, 2012
Increased residual platelet reactivity remains a burden for coronary artery disease (CAD) patients who received a coronary stent and do not respond sufficiently to treatment with acetylsalicylic acid and clopidogrel.
Daniel Duerschmied, Ingo Ahrens, Maximilian Mauler, Christoph Brandt, Stefanie Weidner, Christoph Bode, Martin Moser   +6 more
doaj   +1 more source

Flavonoids: Antiplatelet Effect as Inhibitors of COX-1

Molecules, 2022
Flavonoids are compounds with a benzopyranic structure that exhibits multiple pharmacological activities. They are known for their venotonic activity, but their mechanism of action remains unclear.
Cristina Zaragozá, Miguel Ángel Álvarez-Mon, Francisco Zaragozá, Lucinda Villaescusa   +3 more
doaj   +1 more source