Results 31 to 40 of about 462,453 (269)

Association between endometrial indoleamine 2,3-dioxygenase expression level and pregnancy outcomes in women undergoing first in vitro fertilization treatment

BMC Pregnancy and Childbirth, 2021
Background Indoleamine 2,3-dioxygenase (IDO) has been reported to play a key role in placental development during normal pregnancy. However, the question of whether endometrial IDO expression affects in vitro fertilization (IVF) pregnancy outcomes ...
Su Liu, Ling Hong, Yuye Li, Ruochun Lian, Xiaohui Wang, Yong Zeng   +5 more
doaj   +1 more source

Piezo-ICSI Reduces Oocyte Degeneration, Improves ICSI Success Rates and Has Shown Less Dependence on the Experience Level of Embryologists: Cumulative Data with 65,033 MII Oocytes

Fertility & Reproduction
Introduction: Recent improvements in mercury-free piezo-assisted intracytoplasmic sperm injection (P-ICSI) devices have renewed interest in this technique, and reports on its usefulness are increasing.
Hideaki Watanabe, Koji Nakagawa, Shota Hatakeyama, Kota Yamamoto, Satomi Takeda, Emi Yamashiro, Asako Shirai, Takashi Horikawa, Keiji Kuroda, Rikikazu Sugiyama   +9 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4

Scientific Reports, 2021
The outer layer of the human placenta comprises syncytiotrophoblast, which forms through fusion of cytotrophoblasts (syncytialization), and plays a critical role in maternal–fetal communication including nutrient/oxygen transportation and hormone ...
Mary Mansilla, Yao Wang, Rebecca Lim, Kirsten Palmer, Guiying Nie   +4 more
doaj   +1 more source

O-23 HEPATITIS B VIRUS STATUS OF ORGAN DONORS IN ARGENTINA

Annals of Hepatology, 2023
Introduction and Objectives: Argentina is considered an area with a low prevalence of hepatitis B virus (HBV). However, the real prevalence of the disease is unknown. We aimed to study the prevalence of HBV in potential cadaveric donors.
Maria Anders, Ariel Antik, Manuel Mendizabal, Federico Piñero, Daniela Hansen Krogh, Federico Orozco, Viviana Tagliafichi, Julia Brutti, Marcelo Silva, Gabriela Hidalgo, Liliana Bisignano   +10 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

O-12 CHARACTERIZATION AND UTILIZATION OF HCV-POSITIVE DONORS IN ARGENTINA

Annals of Hepatology, 2023
Introduction and Objectives: Increased utilization of hepatitis C virus (HCV)-positive organ donors has been endorsed as one of several ways to combat organ shortages. However, HCV-positive donors remain poorly characterized. This study aimed to evaluate
Manuel Mendizabal, Margarita Anders, Ariel Antik, Federico Piñero, Gabriela Hidalgo, Daniela Hansen Krogh, Viviana Tagliafichi, Marcelo Silva, Liliana Bisigniano   +8 more
doaj   +1 more source

Implantation of the Subcutaneous Implantable Cardioverter-Defibrillator [PDF]

Circulation: Arrhythmia and Electrophysiology, 2017
Background— Alternative techniques to the traditional 3-incision subcutaneous implantation of the subcutaneous implantable cardioverter-defibrillator may offer procedural and cosmetic advantages. We evaluate 4 different implant techniques of the subcutaneous implantable cardioverter-defibrillator.
Brouwer, Tom F., Miller, Marc A., Quast, Anne-Floor B. E., Palaniswamy, Chandrasekar, Dukkipati, Srinivas R., Reddy, Vivek, Wilde, Arthur A., Willner, Jonathan M., Knops, Reinoud E.   +8 more
openaire   +3 more sources