Results 41 to 50 of about 972,015 (310)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Aortic stenting in the growing sheep causes aortic endothelial dysfunction but not hypertension: Clinical implications for coarctation repair [PDF]

, 2016
Stent implantation is the treatment of choice for adolescents and adults with aortic coarctation (CoAo). Despite excellent short-term results, 20%-40% of the patients develop arterial hypertension later in life, which was attributed to inappropriate ...
Aresu, Luca, Basso, Cristina, Bernardini, Daniele, Cattelan, Arianna, Ceolotto, Giulio, DE BENEDICTIS, GIULIA MARIA, Gerardi, Gabriele, Iacopetti, Ilaria, Maschietto, Nicola, Milanesi, Ornella, Pilla, Tommaso, Poser, Helen, Rizzo, Stefania, Semplicini, Andrea, Semplicini, Luca   +14 more
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Granulocyte-Macrophage Colony Stimulating Factor in Single Blastocyst Conditioned Medium as a Biomarker for Predicting Implantation Outcome of Embryo

Frontiers in Immunology, 2021
BackgroundIt is highly desirable to develop new strategies based on secretomics to more accurately selection of embryos with the highest developmental potential for transfer.
Peilin Chen, Chunyu Huang, Chunyu Huang, Qing Sun, Huixian Zhong, Feng Xiong, Su Liu, Zhihong Yao, Zhiqiang Liu, Caiyun Wan, Yong Zeng, Lianghui Diao   +11 more
doaj   +1 more source

Prediction of time to prosthesis implantation as a function of joint anatomy in patients with developmental dysplasia of the hip [PDF]

, 2019
BACKGROUND: Developmental dysplasia of the hip (DDH) can lead to pain and premature secondary osteoarthritis at an early stage. Joint-preserving osteotomy is an established solution to this problem.
Müller, Michael, Perka, Carsten, Rakow, Anasthasia, Wassilew, Georgi I., Winkler, Tobias   +4 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Development of audiovisual comprehension skills in prelingually deaf children with cochlear implants [PDF]

, 2005
Objective: The present study investigated the development of audiovisual comprehension skills in prelingually deaf children who received cochlear implants.
Bergeson, Tonya R., Davis, Rebecca A. O., Pisoni, David B.   +2 more
core   +3 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Culture of cryopreserved first trimester placental tissues to study syncytial renewal

Scientific Reports
Ex vivo studies with first trimester placental tissues are crucial for understanding human placental development, and culturing placental villi in floating conditions is vital to mimic the natural setting.
Mary Mansilla, Yao Wang, Guiying Nie
doaj   +1 more source

Transcriptomic profiling analysis of human endometrial stromal cells treated with autologous platelet‐rich plasma

Reproductive Medicine and Biology, 2023
Purpose To clarify the mechanisms of intrauterine platelet‐rich plasma (PRP) infusion that support embryo implantation in in vitro fertilization treatment. Methods Blood and endometrial samples were collected from four infertile women.
Keiji Kuroda, Akemi Matsumoto, Takashi Horikawa, Satoru Takamizawa, Asako Ochiai, Kazuhiro Kawamura, Koji Nakagawa, Rikikazu Sugiyama   +7 more
doaj   +1 more source