Results 91 to 100 of about 28,489,203 (383)

Patient experiences of tuberculosis treatment deferral after a trace Xpert Ultra result: a prospective cohort study

Infectious Diseases of Poverty
Background A “trace” result from the Xpert Ultra molecular tuberculosis test indicates Mycobacterium tuberculosis DNA detection but may not always signify tuberculosis disease.
Caitlin Visek, James Mukiibi, Mariam Nantale, Annet Nalutaaya, Patrick Biché, Joowhan Sung, Francis Kayondo, Joab Akampurira, Michael Mukiibi, Rogers Kiyonga, Achilles Katamba, Emily A. Kendall   +11 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Understanding collaborative care implementation in the Department of Veterans Affairs: core functions and implementation challenges

BMC Health Services Research, 2017
Background The collaborative care model is an evidence-based practice for treatment of depression in which designated care managers provide clinical services, often by telephone.
Jessica M. Lipschitz, Justin K. Benzer, Christopher Miller, Siena R. Easley, Jenniffer Leyson, Edward P. Post, James F. Burgess   +6 more
doaj   +1 more source

A systematic review of the use of the Consolidated Framework for Implementation Research

Implementation Science, 2015
BackgroundIn 2009, Damschroder et al. developed the Consolidated Framework for Implementation Research (CFIR), which provides a comprehensive listing of constructs thought to influence implementation.
M. Kirk, M. Kirk, Caitlin Kelley, Nicholas Yankey, S. Birken, Brenton G. Abadie, L. Damschroder   +6 more
semanticscholar   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Translational and Implementation Research to Bridge Evidence and Implementation [PDF]

Annals of Nutrition and Metabolism, 2019
<b><i>Background:</i></b> The role of science in guiding interventions and programs and contributing to progress in achieving global targets is undeniable. In public health nutrition, biological research in the past century focused largely on single nutrients and provided the basis for addressing nutritional deficiencies.
Kraemer, Klaus, Van Zutphen, Kesso Gabrielle   +1 more
openaire   +3 more sources

How is implementation research applied to advance health in low-income and middle-income countries?

BMJ Global Health, 2019
This paper examines the characteristics of implementation research (IR) efforts in low-income and middle-income countries (LMICs) by describing how key IR principles and concepts have been used in published health research in LMICs between 1998 and 2016,
O. Alonge, D. Rodriguez, N. Brandes, E. Geng, L. Reveiz, D. Peters   +5 more
semanticscholar   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Using an intersectionality lens to explore barriers and enablers to hepatitis C point-of-care testing: a qualitative study among people who inject drugs and service providers

International Journal for Equity in Health
Background Hepatitis C virus (HCV) infection is a significant global health burden, particularly among people who inject drugs. Rapid point-of-care HCV testing has emerged as a promising approach to improve HCV detection and linkage to care in harm ...
Guillaume Fontaine, Justin Presseau, Julie Bruneau, Cole Etherington, Isabella M. Thomas, Jui-Hsia Cleo Hung, Zack van Allen, Andrea M. Patey, Ayesha Kareem, Sameh Mortazhejri, Stine Bordier Høj, Geneviève Boyer-Legault, Jeremy M. Grimshaw   +12 more
doaj   +1 more source