Advanced Science, EarlyView.The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu +10 more
wiley +1 more source
Uncovering the phenotypic consequences of multi-locus imprinting disturbances using genome-wide methylation analysis in genomic imprinting disorders. [PDF]
PLoS One, 2023 Kim HY, Shin CH, Shin CH, Ko JM.
europepmc +1 more source
Human imprinting disorders: Principles, practice, problems and progress
European Journal of Medical Genetics, 2017 Epigenetic regulation orchestrates gene expression with exquisite precision, over a huge dynamic range and across developmental space and time, permitting genomically-homogeneous humans to develop and adapt to their surroundings. Every generation, these epigenetic marks are re-set twice: in the germline, to enable differentiation of sperm and eggs, and
Deborah J.G. Mackay, I. Karen Temple
openaire +5 more sources
Developing Micro/Nanostructured Fluidic Mixing Technology for Biomedical Applications
Advanced Science, EarlyView.This review critically evaluates how micro/nanostructured mixing technologies are redefining biomedical research. By synergizing fundamental analysis, numerical modeling, structural design, and external field manipulation, these systems attain unprecedented control over mass transport.
Junkai Wang +3 more
wiley +1 more source
First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders. [PDF]
Clin Epigenetics, 2022 Mackay D +28 more
europepmc +1 more source
Ferromagnetic Resonance Response of bcc Fe60V40 Layers Generated from Short‐Range Ordered Precursors
Advanced Electronic Materials, EarlyView.ABSTRACT Layers of body‐centered cubic (bcc) Fe60V40 are generated in short‐range ordered (SRO) Fe60V40 precursors through atomic displacements caused by the irradiation of light noble gas ions. The structural change leads to the onset of ferromagnetism confined to the bcc layers. Here, the variation of ferromagnetic resonance response as a function of
Md. Shadab Anwar +9 more
wiley +1 more source
Degradation Pathways of Silicon‐Based Anodes in Lithium‐Ion Batteries
Advanced Energy Materials, EarlyView.Silicon‐based anodes undergo degradation through five primary pathways: (1) mechanical and structural deterioration of the active material, (2) loss of electrode integrity and electrical contact, (3) mechanical instability of the solid electrolyte interphase (SEI), characterized by repetitive fracture and deformation, (4) chemical instability of the ...
Yoon Jeong Choi +3 more
wiley +1 more source
Risk assessment of assisted reproductive technology and parental age at childbirth for the development of uniparental disomy-mediated imprinting disorders caused by aneuploid gametes. [PDF]
Clin Epigenetics, 2023 Hara-Isono K +10 more
europepmc +1 more source
Advanced Energy Materials, EarlyView.This review focuses on operando studies of battery materials by X‐ray diffraction (XRD) and total X‐ray scattering (TXS). This work highlights potential pitfalls and identify best‐practices for operando studies and reviews some unusual experiments to illustrate how these methods can be applied beyond the evaluation of the early‐stage cycling mechanisms
Amalie Skurtveit +5 more
wiley +1 more source
Clinical EpigeneticsBackground Imprinting disorders are rare diseases resulting from altered expression of imprinted genes, which exhibit parent-of-origin-specific expression patterns regulated through differential DNA methylation.
Deborah J. G. Mackay +31 more
doaj +1 more source