Results 181 to 190 of about 17,518 (240)

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Mechanisms controlling genomic imprinting and their dysregulation in human imprinting disorders

Annales d'Endocrinologie
Aurélien Juven, Catherine Vaurs-Barrière, Franck Court, Bertille Montibus, Philippe Arnaud   +4 more
openaire   +1 more source

Challenges and emerging strategies for genome-wide evaluation of loss of imprinting in cancer. [PDF]

Br J Biomed Sci
Amin MT, Coussement L, De Meyer T.
europepmc   +1 more source

Decoding the “Metallic” Immune Imprint: Single‐Cell Exposomics Reveals the Immune Imprint of Fire Smoke

Allergy, EarlyView.
Takafumi Kubota, Yuki Matsumoto, Takahiro Tabuchi   +2 more
wiley   +1 more source

Contextualising Mental Privacy in South Africa: Legal, Ethical, and Socio‐Cultural Considerations With Policy Recommendations

Developing World Bioethics, EarlyView.
ABSTRACT Mental privacy is a growing concern as neurotechnologies and digital mental health tools collect and process sensitive brain‐related data. In South Africa, cultural and religious diversity adds complexity to protecting mental privacy, with traditional healing practices, communal decision‐making, and spiritual beliefs influencing mental health ...
Marietjie Botes, Melodie Labuschaigne, Camille Casteleyn, Becky Inkster, Mark Sheppard   +4 more
wiley   +1 more source

How Common Is Hypercortisolism in Patients With Hypertension? Risk Factors, Epidemiology, and Making a Diagnosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Endogenous hypercortisolism (EHC) is an underrecognised and clinically significant contributor to hypertension, particularly resistant hypertension. Once viewed as a rare entity, EHC is now understood as a spectrum of cortisol excess associated with adverse cardiometabolic outcomes and target‐organ damage.
Omar Al Dhaybi, Deepak L. Bhatt
wiley   +1 more source

Organisational dehumanisation: Authoritativeness as remedy

European Management Review, EarlyView.
Abstract According to orthodoxy, the human relations movement was a watershed in rehumanising scientifically managed workplaces. In the wake of such purported reform, pundits (theorists and practitioners alike) have typically taken for granted that 21st century approaches to workplace superintendence, birthed in the wake of the Hawthorne Studies and ...
Jean‐Etienne Joullié, Anthony M. Gould, Jeffrey Muldoon   +2 more
wiley   +1 more source

Genomic Imprinting, Epigenetic Dysregulation, and Neuropsychiatric Mechanisms in Prader-Willi Syndrome: A Multi-Level Integrative Review. [PDF]

Cells
Śledzikowska Z, Żukow XE, Antos ZM, Waszkiewicz N.   +3 more
europepmc   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source