Results 201 to 210 of about 18,499 (269)

Soft Colloidal Robots: Magnetically Guided Liquid Crystal Torons for Targeted Micro‐Cargo Delivery

Small, EarlyView.
Torons, topological quasiparticles in liquid crystals, can be propelled using electric fields and precisely steered with magnetic alignment, enabling programmable motion without fluid flow. In microfluidic channels, they transport colloidal cargo and exhibit novel dynamic behavior. Their uniformity, softness, and reconfigurability make torons ideal for
Joel Torres‐Andrés, Rodrigo C. V. Coelho, Patrick Oswald, Francesc Sagués, Jordi Ignés‐Mullol   +4 more
wiley   +1 more source

Innovative Microneedle Patches for Psoriasis Treatment: A Dual Approach With Methotrexate‐Zinc and Difelikefalin for Enhanced Therapeutic Outcomes

Small, EarlyView.
This study presents a novel dual‐layer microneedle platform for psoriasis treatment, integrating rapid itch relief with sustained immunomodulatory and antibacterial effects. By combining difelikefalin and methotrexate‐zinc, this system effectively targets pruritus, epidermal hyperplasia, immune dysregulation, and infection, offering a promising ...
Xiaolong Xu, Chunhao Long, Yuze Zhou, Lujing Fei, Youyou Zhou, Min Qi   +5 more
wiley   +1 more source

Physical Anchoring‐Assisted Mechanically Guided Assembly for Material‐Independent 3D Mesostructures

Small, EarlyView.
Conventional mechanically guided 3D assembly relies on selective chemical bonding between 2D precursors and elastomeric substrates, imposing fundamental limitations on material compatibility and scalability. Here, we present a physically anchored, buckling‐guided assembly platform based on a rod array patterned elastomeric substrate (RPES).
Yeonhee Heo, Pei Liu, Jeongmin Yoo, Jae Hyuk Hwang, Gooyoon Chung, Dong‐Gyun Kim, Raudel Avila, Yoonseok Park   +7 more
wiley   +1 more source

VISUAL NEGOTIATIONS OF GENTRIFICATION IN TORONTO: Contestation, Politicization and Resistance through Urban Signage

International Journal of Urban and Regional Research, EarlyView.
Abstract This article engages signage as a medium through which urban stakeholders negotiate the politics of housing redevelopment and gentrification in cities. Focusing on Toronto, we examine housing‐related signage in three neighbourhoods where social mix approaches to redevelopment have ushered in gentrification: Parkdale, Regent Park, and Moss Park.
Lindi Jahiu, Jonathan Cinnamon, Agnieszka Leszczynski   +2 more
wiley   +1 more source

Becoming monstrous: Beauty norms, body image, and discursive limits on compassion in The Substance

Nutrition &Dietetics, EarlyView.
Abstract Aim This study analyses the Hollywood body horror film The Substance to explore how Western beauty culture regulates emotions and bodies. It aims to explore compassion within dominant body image discourses and considers how this impacts dietetic care. Methods Using Foucauldian discourse analysis informed by affect theory, the film was analysed
Phillip Joy
wiley   +1 more source

‘I, Me, Myself’: Selfhood and Melancholy in the Journals of Gertrude Savile (1697–1758)

Journal for Eighteenth-Century Studies, EarlyView.
Abstract This article examines the journals of Gertrude Savile from 1727 in light of recent scholarship on early modern and eighteenth‐century melancholy. The concept had myriad associations with medicine, physiology, the imagination, and feeling, but questions remain about how melancholy during this period was considered by those outside the narrow ...
Daniel Beaumont
wiley   +1 more source

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source