Results 81 to 90 of about 497,128 (308)
Functional and structural analysis of missense variants in the human PDCD1 Gene
Journal of Public Health in AfricaBackground: Programmed death-1 (PD-1) is an immune checkpoint receptor that regulates T-cell function by modulating and terminating immune responses.
Hanâ Baba +8 more
doaj +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6- (3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one [PDF]
, 2018 Natural and semi-synthetic compounds are being studied as novel phosphodiesterase 5 (PDE5) inhibitors for the treatment of erectile dysfunction, pulmonary hypertension, and lower urinary symptoms.
Ongaro, Alberto +2 more
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Characterization of pinctada fucata mantle gene 2 (pfmg2) in pearl oyster
Biotechnology & Biotechnological Equipment, 2017 Biomineralization is a complicated process which involves multiple gene products in Pinctada fucata. Here, Pinctada fucata mantle gene 2 (pfmg2) was characterized in P. fucata. The putative PFMG2 protein has a Calponin Homology (CH) domain and an EF hand
Xiaoyan Wang +3 more
doaj +1 more source
In silico Analysis of qBFR4 and qLBL5 in Conferring Quantitative Resistance Against Rice Blast
Journal of Pure and Applied Microbiology, 2018 The devastating yield losses caused by rice blast can be mitigated by breeding resistant cultivars with QTLs enriched with resistance (R-gene) and defence related genes. These genes are the arsenal of the plant’s immune system against pathogen invasion.
Ilakiya Sharanee Kumar +2 more
doaj +1 more source
Variable predicted pathogenic mechanisms for novel MECP2 variants in RTT patients
Journal of Genetic Engineering and Biotechnology, 2022 Background Methyl CpG binding protein 2 (MeCP2) is essential for the normal function of mature neurons. Mutations in the MECP2 gene are the main cause of Rett syndrome (RTT). Gene mutations have been identified throughout the gene and the mutation effect
Wessam E. Sharaf-Eldin +4 more
doaj +1 more source
RTPrimerDB : the portal for real-time PCR primers and probes [PDF]
, 2009 RTPrimerDB (http://www.rtprimerdb.org) is a freely accessible database and analysis tool for real-time quantitative PCR assays. RTPrimerDB includes records with user submitted assays that are linked to genome information from reference databases and ...
S. Lefever +7 more
core +2 more sources
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source