Results 161 to 170 of about 169,844 (308)

In-silico design of a multi-epitope vaccine candidate against Strongyloides stercoralis. [PDF]

BMC Infect Dis
Stong Tangan YA, Nchanji GT, Ndumu E, Ayuk AB, Ngala KB, Dulandzev MB, Yaah NE, Shinyuy LM, Shintouo CM, Yengo BN, Enowkpen AE, Efeti MT, Chick JA, Gwei KY, Lemoge AA, Vanhamme L, Souopgui J, Ghogomu SM, Shey RA.   +18 more
europepmc   +1 more source

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, EarlyView.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

In silico design of a multiepitope vaccine against antibiotic drug-resistant Acinetobacter baumannii. [PDF]

Sci Rep
Khadka S, Khan MA, Iqbal S, Ullah A, Ahmad A, Khan NZ, Khattak A.   +6 more
europepmc   +1 more source

Shear‐Induced Emergence of Aromatic Superlow‐Friction Interfaces in Amorphous Carbon: Triggering Chemical Impurities and Atomic‐Scale Mechanisms

Advanced Science, EarlyView.
High‐throughput quantum‐mechanical simulations reveal that amorphous carbon undergoes shear‐driven structural transformation into aromatic, graphene‐like interfaces. This mechanochemical process is governed by dopant chemistry: dopants with valency less than four promote the emergence of superlow‐friction amorphous graphene, whereas tetra‐valent ...
Takuya Kuwahara, Koki Horiguchi, Leonhard Mayrhofer, Gianpietro Moras, Michael Moseler   +4 more
wiley   +1 more source

CustomKinFragLib: Filtering the Kinase-Focused Fragmentation Library

ACS Omega
Paula Linh Kramer, Katharina Buchthal, Dominique Sydow, Katharina Sonja Leo, Andrea Volkamer   +4 more
doaj   +1 more source

In silico design and immunoinformatics evaluation of a multi-epitope vaccine targeting SEPT9 for gastrointestinal adenocarcinomas. [PDF]

BMC Immunol
Kashyap H, Rathi B, Singh H, Kaur N, Sharda S, Sharma AK.   +5 more
europepmc   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

In silico design and immunoinformatics assessment of a multiepitope vaccine targeting borealpox virus. [PDF]

Sci Rep
Naveed M, Asim M, Aziz T, Athar A, Majeed MN, Tombozara N, Al-Zaban MI, Shami A, Alwethaynani MS, Al-Joufi FA.   +9 more
europepmc   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV-2 using immunoinformatics. [PDF]

PLoS Negl Trop Dis
Zheng N, Xu Y.
europepmc   +1 more source