Results 151 to 160 of about 115,710,970 (297)

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

amostof/In-silico-model-development-paper: v1.0

<p>The code for the paper "In silico model development and optimization of in vitro lung cell population growth" submitted to PLOS One</p ...
Amirmahdi Mostofinejad
core   +1 more source

In-silico design of a multi-epitope vaccine candidate against Strongyloides stercoralis. [PDF]

BMC Infect Dis
Stong Tangan YA, Nchanji GT, Ndumu E, Ayuk AB, Ngala KB, Dulandzev MB, Yaah NE, Shinyuy LM, Shintouo CM, Yengo BN, Enowkpen AE, Efeti MT, Chick JA, Gwei KY, Lemoge AA, Vanhamme L, Souopgui J, Ghogomu SM, Shey RA.   +18 more
europepmc   +1 more source

In silico design of peptides with functionality

, 2021
74
openaire   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies. [PDF]

Elife
Yang Y, Qiao L, Jiang Y, Wang Z, Zhang D, Buratto D, Huang L, Zhou R.   +7 more
europepmc   +1 more source

Continuous Evolution System Based on Toxin–Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins

Advanced Science, EarlyView.
The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Mingjing Sun, Guangzhen Zhou, Deming Rao, Xiaoqian Chen, Sheng Wang, Zhigang Li, Yan Huang, Jing Wu   +10 more
wiley   +1 more source

In silico design of a multiantigenic and multiepitope chimeric protein as a vaccine candidate against <i>Renibacterium salmoninarum</i>. [PDF]

Front Cell Infect Microbiol
Araneda J, Flores-Herrera PA, Acevedo W, Marshall SH, Gómez FA.   +4 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

In Silico Design and Computational Characterization of Novel Chimeric Multiepitope Antigens for Mpox Serosurveillance: An Immunoinformatics Approach. [PDF]

Health Sci Rep
Akwelle RN, Shey RA, Efeti MT, Acha LN, Nchanji GT, Tangan YAS, Chick JA, Yaah NE, Shinyuy LM, Shintouo CM, Yengo BN, Ayuk AB, Engarimbi JE, Gwei KY, Tebo BT, Nebangwa DN, Tamnjong BM, Vanhamme L, Souopgui J, Titanji VPK, Ghogomu SM.   +20 more
europepmc   +1 more source