Protein folding in silico : protein folding versus protein structure prediction /
, 2012 Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction.
Roterman-Konieczna, Irena,editor.
core
Advanced Science, EarlyView.TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu +12 more
wiley +1 more source
In-silico design of a multi-epitope vaccine candidate against Strongyloides stercoralis. [PDF]
BMC Infect DisStong Tangan YA +18 more
europepmc +1 more source
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
In Silico Design of Molecular Precursors for Solution-Processable Organic Semiconductors: Structure and Electronic Properties of Sym-Azathio Circulenes. [PDF]
ACS OmegaCasalegno M, Genoni A.
europepmc +1 more source
Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Advanced Science, EarlyView.A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu +15 more
wiley +1 more source
In silico design of a multiantigenic and multiepitope chimeric protein as a vaccine candidate against <i>Renibacterium salmoninarum</i>. [PDF]
Front Cell Infect MicrobiolAraneda J +4 more
europepmc +1 more source
Advanced Science, EarlyView.We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka +10 more
wiley +1 more source
CustomKinFragLib: Filtering the Kinase-Focused Fragmentation Library
ACS OmegaPaula Linh Kramer +4 more
doaj +1 more source
In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies. [PDF]
ElifeYang Y +7 more
europepmc +1 more source