Results 141 to 150 of about 169,844 (308)
Ultra-long-term knee wear testing: an in-silico perspective
, 2010 Wear is one of the many factors which concern total knee replacement (TKR) designers. With younger patients & increasing life expectancy, new TKR designs face a longer service life[1].
Knight, L.A. +2 more
core
In-silico product formulation design through latent variable model inversion
, 2014 Two of the first important decisions to take in the development of a solid oral drug product are the selection of excipients that are to be mixed with the active pharmaceutical ingredient (API) in a commercial formulation, and the manufacturing route ...
TOMBA, EMANUELE +2 more
core +1 more source
Traction Force Microscopy for Viscoelastic Substrates: A Semi‐Analytical Method
Advanced Science, EarlyView.A semi‐analytical viscoelastic traction force microscopy framework is introduced for quantifying time‐resolved cell tractions on flat finite‐thickness substrates. The method generalizes elastic traction force microscopy to Generalized Maxwell materials, identifies when elastic approximations remain valid and, when they do not, shows that inferred ...
Adrià Villacrosa‐Ribas +10 more
wiley +1 more source
Governance in Silico: Experimental Sandbox for Policymaking over AI Agents
The concept of \u27governance in silico\u27 summarizes and questions the design and policy experiments with synthetic data and content in public policy, such as synthetic data simulations, AI agents, and digital twins.
Kalvas, Frantisek +3 more
core +1 more source
, 2016 Correction to In Silico Molecular Design, Synthesis, Characterization, and Rheology of Dendritically Branched Polymers: Closing the Design ...
David M. Hoyle (2073148) +8 more
core +1 more source
Advanced Science, EarlyView.Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng +11 more
wiley +1 more source
Background: Malaria remains a significant global health burden, particularly in sub-Saharan Africa, accounting for high rates of illness and death. The growing resistance to frontline antimalarial therapies underscores the urgent need for novel drug ...
Gbolahan O. Oduselu +5 more
core +1 more source
MFPD: A Multiple Fungal Pathogen Detection Pipeline Across Diverse Habitats
Advanced Science, EarlyView.The MFPD pipeline integrates a comprehensive ITS reference database of fungal pathogens, optimized parameters, and algorithms tailored for both full‐length and subregion sequences that balance accuracy and computational efficiency; it enables high‐throughput, species‐level identification from amplicon sequencing data, supporting large‐scale ...
Yi Shen +13 more
wiley +1 more source
Advanced Science, EarlyView.A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park +11 more
wiley +1 more source
Advanced Science, EarlyView.Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao +7 more
wiley +1 more source