Results 181 to 190 of about 115,710,970 (297)

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Advanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Understanding laccases stability and glycosylation effect by integrating computational and experimental studies

, 2012
EBERT, CYNTHIA, Golovleva, L., FATTOR, DIANA, FOSCATO, MARCO, SINIGOI, LORIS, GARDOSSI, Lucia, FERRARIO, VALERIO, Cherykh, A.   +7 more
core  

In Silico Design and Subsequent Expression of Human Papillomavirus-16 and -18 L1 Vaccine Antigens in Broccoli. [PDF]

Vaccines (Basel)
Batool N, Ahsan K, Qadeer K, Fajar A, Farid A, Sameeullah M, Ijaz F, Malik MS, Tariq FA, Lössl AG, Müller M, Waheed MT.   +11 more
europepmc   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Automatic evolution of mutants by means of MODEFRONTIER software

, 2012
EBERT, CYNTHIA, FOSCATO, MARCO, GARDOSSI, Lucia, FERRARIO, VALERIO, KNAPIC, Lorena, Stefano, D. Di   +5 more
core  

In Silico Design and Evaluation of TcGAPDH as a Vaccine Against Chagas Disease: A Reverse Vaccinology Approach. [PDF]

Acta Parasitol
Nava-Cuamatzi V, Buendia-Corona RE, González-Vázquez MC, Cedillo-Ramirez ML, Carabarin-Lima A.   +4 more
europepmc   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

Conformational study of lipases in different media: experimental implications for the conversion of oils from coffee waste in biodiesel

, 2012
SPIZZO, PATRIZIA, EBERT, CYNTHIA, FATTOR, DIANA, Navarini, . C., GARDOSSI, Lucia, FERRARIO, VALERIO, CANTONE, SARA, De Angelis, E.   +7 more
core  

In silico design of a multi-epitope pan vaccine targeting Schistosoma species. [PDF]

Genomics Inform
Gandvi D, Jyotishi C, Patel M, Gupta R.
europepmc   +1 more source

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source