Results 1 to 10 of about 165,849 (202)
Toward the Next Generation of In Silico Modeling of Dynamic Host-Microbiota Interactions in the Skin [PDF]
JID InnovationsUnderstanding how the skin microbiota contributes to skin health and disease requires knowledge of the dynamic interactions between the skin and its resident microbes.
Jamie Lee +6 more
doaj +2 more sources
Frontiers in Physiology, 2023 Intracardiac electrograms (iEGMs) are time traces of the electrical potential recorded close to the heart muscle. We calculate unipolar and bipolar iEGMs analytically for a myocardial slab with parallel myofibers and validate them against numerical ...
Lore Leenknegt +4 more
doaj +1 more source
Application in silico Modeling Simulation in Bioequivalence Studies: A Review
Journal of Food and Pharmaceutical Sciences, 2023 Bioequivalence testing aims to ensure that the therapeutic performance of the drug is consistent and reproducible when it is administrated. Modeling and simulation in silico methods are currently performed to conduct virtual bioequivalence studies ...
Sekar Ayu Pawestri
doaj +1 more source
Semantically Linking in Silico Cancer Models [PDF]
Cancer Informatics, 2014 Multiscale models are commonplace in cancer modeling, where individual models acting on different biological scales are combined within a single, cohesive modeling framework. However, model composition gives rise to challenges in understanding interfaces and interactions between them.
Johnson, D +6 more
openaire +7 more sources
In Silico Hemostasis Modeling and Prediction [PDF]
Hämostaseologie, 2020 AbstractComputational physiology, i.e., reproduction of physiological (and, by extension, pathophysiological) processes in silico, could be considered one of the major goals in computational biology. One might use computers to simulate molecular interactions, enzyme kinetics, gene expression, or whole networks of biochemical reactions, but it is (patho)
Dmitry Y, Nechipurenko +3 more
openaire +2 more sources
Fluctuating Nonlinear Spring Model of Mechanical Deformation of Biological Particles [PDF]
, 2015 We present a new theory for modeling forced indentation spectral lineshapes of biological particles, which considers non-linear Hertzian deformation due to an indenter-particle physical contact and bending deformations of curved beams modeling the ...
Gijs J L Wuite +6 more
core +7 more sources
Plant catalase in silico characterization and phylogenetic analysis with structural modeling
Journal of Genetic Engineering and Biotechnology, 2022 Background Catalase (EC 1.11.1.6) is a heme-containing tetrameric enzyme that plays a critical role in signaling and hydrogen peroxide metabolism. It was the first enzyme to be crystallized and isolated. Catalase is a well-known industrial enzyme used in
Takio Nene +2 more
doaj +1 more source
Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]
, 2010 Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T. +6 more
core +15 more sources
In silico imaging clinical trials: cheaper, faster, better, safer, and more scalable
Trials, 2021 Imaging clinical trials can be burdensome and often delay patient access to novel, high-quality medical devices. Tools for in silico imaging trials have significantly improved in sophistication and availability.
Aldo Badano
doaj +1 more source
Drug Delivery, 2022 Transdermal fentanyl patches are an effective alternative to the sustained release of oral morphine for chronic pain management. Due to the narrow therapeutic range of fentanyl, the concentration of fentanyl in the blood needs to be carefully monitored ...
Flora Bahrami +2 more
doaj +1 more source