Results 1 to 10 of about 236,499 (183)

In silico modeling for ex vivo placenta perfusion of nicotine. [PDF]

Front Pharmacol
Nicotine readily crosses the placenta to reach fetuses. However, membrane transporters, e.g., organic cation transporters (OCTs) play a role in the clearance of nicotine from the fetal to the maternal side, and this is rarely investigated clinically.
Ho H, Zhang S, Kurosawa K, Jiang B, Chiba K.   +4 more
europepmc   +2 more sources

Toward the Next Generation of In Silico Modeling of Dynamic Host-Microbiota Interactions in the Skin [PDF]

JID Innovations
Understanding how the skin microbiota contributes to skin health and disease requires knowledge of the dynamic interactions between the skin and its resident microbes.
Jamie Lee, Hiu Lam Athena Wu, Ahmad A. Mannan, Yuumi Nakamura, Masayuki Amagai, Alan D. Irvine, Reiko J. Tanaka   +6 more
doaj   +2 more sources

Multiscale In Silico Modeling of Cartilage Injuries.

Advances in Experimental Medicine and Biology, 2023
Injurious loading of the joint can be accompanied by articular cartilage damage and trigger inflammation. However, it is not well-known which mechanism controls further cartilage degradation, ultimately leading to post-traumatic osteoarthritis.
Rami K. Korhonen, A. S. Eskelinen, Gustavo A. Orozco, A. Esrafilian, C. Florea, P. Tanska   +5 more
semanticscholar   +1 more source

Impact of electrode orientation, myocardial wall thickness, and myofiber direction on intracardiac electrograms: numerical modeling and analytical solutions

Frontiers in Physiology, 2023
Intracardiac electrograms (iEGMs) are time traces of the electrical potential recorded close to the heart muscle. We calculate unipolar and bipolar iEGMs analytically for a myocardial slab with parallel myofibers and validate them against numerical ...
Lore Leenknegt, Lore Leenknegt, Alexander V. Panfilov, Hans Dierckx, Hans Dierckx   +4 more
doaj   +1 more source

High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling

Stem Cells Translational Medicine, 2021
To harness the full potential of human pluripotent stem cells (hPSCs) we combined instrumented stirred tank bioreactor (STBR) technology with the power of in silico process modeling to overcome substantial, hPSC‐specific hurdles toward their mass ...
Felix Manstein, Kevin Ullmann, C. Kropp, Caroline Halloin, Wiebke Triebert, A. Franke, Clara-Milena Farr, Anais Sahabian, A. Haase, Y. Breitkreuz, M. Peitz, O. Brüstle, S. Kalies, U. Martin, R. Olmer, R. Zweigerdt   +15 more
semanticscholar   +1 more source

SP-A binding to the SARS-CoV-2 spike protein using hybrid quantum and classical in silico modeling and molecular pruning by Quantum Approximate Optimization Algorithm (QAOA) Based MaxCut with ZDOCK

Frontiers in Immunology, 2022
The pulmonary surfactant protein A (SP-A) is a constitutively expressed immune-protective collagenous lectin (collectin) in the lung. It binds to the cell membrane of immune cells and opsonizes infectious agents such as bacteria, fungi, and viruses ...
Sona Aramyan, K. McGregor, S. Sandeep, A. Haczku   +3 more
semanticscholar   +1 more source

Application in silico Modeling Simulation in Bioequivalence Studies: A Review

Journal of Food and Pharmaceutical Sciences, 2023
Bioequivalence testing aims to ensure that the therapeutic performance of the drug is consistent and reproducible when it is administrated. Modeling and simulation in silico methods are currently performed to conduct virtual bioequivalence studies ...
Sekar Ayu Pawestri
doaj   +1 more source

Plant catalase in silico characterization and phylogenetic analysis with structural modeling

Journal of Genetic Engineering and Biotechnology, 2022
Background Catalase (EC 1.11.1.6) is a heme-containing tetrameric enzyme that plays a critical role in signaling and hydrogen peroxide metabolism. It was the first enzyme to be crystallized and isolated. Catalase is a well-known industrial enzyme used in
Takio Nene, Meera Yadav, Hardeo Singh Yadav   +2 more
doaj   +1 more source

Fluctuating Nonlinear Spring Model of Mechanical Deformation of Biological Particles [PDF]

, 2015
We present a new theory for modeling forced indentation spectral lineshapes of biological particles, which considers non-linear Hertzian deformation due to an indenter-particle physical contact and bending deformations of curved beams modeling the ...
Gijs J L Wuite, Joost Snijder, Kenneth A Marx, Olga Kononova, Valeri Barsegov, Wouter H Roos, Yaroslav Kholodov   +6 more
core   +7 more sources

From Infection to Immunity: Understanding the Response to SARS-CoV2 Through In-Silico Modeling

bioRxiv, 2020
Background Immune system conditions of the patient is a key factor in COVID-19 infection survival. A growing number of studies have focused on immunological determinants to develop better biomarkers for therapies.
F. Castiglione, Debashrito Deb, A. Srivastava, Pietro Lio’, A. Liso   +4 more
semanticscholar   +1 more source