Results 11 to 20 of about 165,849 (202)

Continuum Modeling and Simulation in Bone Tissue Engineering [PDF]

, 2019
Bone tissue engineering is currently a mature methodology from a research perspective. Moreover, modeling and simulation of involved processes and phenomena in BTE have been proved in a number of papers to be an excellent assessment tool in the stages ...
Reina Romo, Esther, Sanz Herrera, José Antonio   +1 more
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Modeling Neurodegeneration in silico With Deep Learning [PDF]

Frontiers in Neuroinformatics, 2021
Deep neural networks, inspired by information processing in the brain, can achieve human-like performance for various tasks. However, research efforts to use these networks as models of the brain have primarily focused on modeling healthy brain function so far.
Anup Tuladhar, Anup Tuladhar, Jasmine A. Moore, Jasmine A. Moore, Jasmine A. Moore, Zahinoor Ismail, Zahinoor Ismail, Zahinoor Ismail, Zahinoor Ismail, Zahinoor Ismail, Nils D. Forkert, Nils D. Forkert, Nils D. Forkert, Nils D. Forkert   +13 more
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Agent-based computational modeling of wounded epithelial cell monolayers [PDF]

, 2004
Computational modeling of biological systems, or ‘in silico biology’ is an emerging tool for understanding structure and order in biological tissues. Computational models of the behavior of epithelial cells in monolayer cell culture have been developed ...
Hill, G., Smallwood, R.H., Southgate, J., Walker, D.C., Wood, S.M.   +4 more
core   +1 more source

Structural Equation Modeling of In silico Perturbations [PDF]

Frontiers in Genetics, 2021
Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in humans.
Jianying Li, Jianying Li, Jianying Li, Pierre R. Bushel, Pierre R. Bushel, Lin Lin, Lin Lin, Kevin Day, Tianyuan Wang, Tianyuan Wang, Francesco J. DeMayo, San-Pin Wu, Jian-Liang Li   +12 more
openaire   +5 more sources

A clinically aligned experimental approach for quantitative characterization of patient-specific cardiovascular models

AIP Advances, 2020
Recent improvements in computational tools opened the possibility of patient-specific modeling to aid clinicians during diagnosis, treatment, and monitoring. One example is the modeling of blood flow for surgical planning, where modeling can help predict
Ana Paula Narata, Fernando Silva de Moura, Fréderic Patat, Alberto Marzo, Ignacio Larrabide, Jean-Marc Gregoire, Cecile Perrault, Charles A. Sennoga, Ayache Bouakaz   +8 more
doaj   +1 more source

In silico modeling of oxygen-enhanced MRI of specific ventilation. [PDF]

, 2018
Specific ventilation imaging (SVI) proposes that using oxygen-enhanced 1H MRI to capture signal change as subjects alternatively breathe room air and 100% O2 provides an estimate of specific ventilation distribution in the lung.
Burrowes, Kelly S, Clark, Alys R, Geier, Eric T, Kang, Wendy, Prisk, G Kim, Sá, Rui C, Tawhai, Merryn H   +6 more
core   +1 more source

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice [PDF]

, 2013
We combined in silico, in vivo, and in vitro studies to gain insights into age-dependent changes in acute inflammation in response to bacterial endotoxin (LPS). Time-course cytokine, chemokine, and NO2-/NO3- data from "middle-aged" (6-8 months old) C57BL/
A Torres, AA Beharka, AK Schroder, C Franceschi, C Franceschi, C Nathan, CC Chow, CE Lagoa, CR Gomez, DC Morrison, DE Zak, Derek Barclay, Derya Unutmaz, DO Adams, E Alvarez, E Cevenini, EZ Bagci, EZ Bagci, F Aujard, F L’Episcopo, FM Ocasio, G Nieman, H Ochi, H Saito, H Wang, IR Turnbull, J Plowden, JM Cavaillon, JM Prince, John Bartels, K Tateda, KM Greeneltch, L Alvarez-Rodriguez, L Ferrucci, M Gurven, MA West, MJ Yang, R Kumar, R Ostan, RA Kohman, Rami A. Namas, RB Effros, RJ Fahy, RL Zhang, Rosemary Hoffman, Ruben Zamora, S Daun, S Gordon, SC Kang, SF Bradley, SN Zykova, T Inamizu, Timothy R. Billiar, TP Plackett, U Fagiolo, W Schumer, W Wiktor-Jedrzejczak, Y Hasegawa, Y Ito, Y Vodovotz, Y Vodovotz, Y Vodovotz, Yoram Vodovotz, Z Yang   +63 more
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Identification of Potential COX-2 Inhibitors for the Treatment of Inflammatory Diseases Using Molecular Modeling Approaches

Molecules, 2020
Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed in order to avoid the side effects of non-selective inhibitors of COX-1. Thus, the present study aims to identify new selective chemical entities for the
Pedro H. F. Araújo, Ryan S. Ramos, Jorddy N. da Cruz, Sebastião G. Silva, Elenilze F. B. Ferreira, Lúcio R. de Lima, Williams J. C. Macêdo, José M. Espejo-Román, Joaquín M. Campos, Cleydson B. R. Santos   +9 more
doaj   +1 more source

Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Showed Cardioprotection Effect in a Myocardial Ischemia (MI) Mouse Model

Proceedings, 2019
TLR4, a member of the toll-like receptors (TLRs) family, serves as a pattern recognition receptor in the innate immune response to different microbial pathogens. [...]
Lena Trifonov, Vadim Nudelman, Michael Zhenin, Guy Cohen, Krzysztof Jozwiak, Edward Korshin, Hanoch Senderowitz, Asher Shainberg, Edith Hochhauser, Arie Gruzman   +9 more
doaj   +1 more source

In silico modelling of DNA nanostructures

Computational and Structural Biotechnology Journal, 2020
The rise of material science and nanotechnology created a demand for a next generation of materials and procedures that can transcend the shaping of simple geometrical nano-objects. As a legacy of the technological progress made in the Human Genome Project, DNA was identified as a possible candidate.
Kekic, Tadija, Barisic, Ivan
openaire   +3 more sources