Results 21 to 30 of about 236,648 (327)

In silico modeling of the α7 nicotinic acetylcholine receptor: new pharmacological challenges associated with multiple modes of signaling.

Mini-Reviews in Medical Chemistry, 2020
The α7 nicotinic acetylcholine receptor is a homopentameric ion-channel of the Cys-loop superfamily characterized by its low probability of opening, high calcium permeability, and rapid desensitization. The α7 receptor has been targeted for the treatment
Alican Gulsevin, R. Papke, N. Horenstein
semanticscholar   +1 more source

Computational Language Modeling and the Promise of In Silico Experimentation

Neurobiology of Language, 2023
Language neuroscience currently relies on two major experimental paradigms: controlled experiments using carefully hand-designed stimuli, and natural stimulus experiments.
Shailee Jain, Vy A. Vo, Leila Wehbe, Alexander G. Huth   +3 more
semanticscholar   +1 more source

Structural Equation Modeling of In silico Perturbations [PDF]

Frontiers in Genetics, 2021
Gene expression is controlled by multiple regulators and their interactions. Data from genome-wide gene expression assays can be used to estimate molecular activities of regulators within a model organism and extrapolate them to biological processes in humans.
Jianying Li, Jianying Li, Jianying Li, Pierre R. Bushel, Pierre R. Bushel, Lin Lin, Lin Lin, Kevin Day, Tianyuan Wang, Tianyuan Wang, Francesco J. DeMayo, San-Pin Wu, Jian-Liang Li   +12 more
openaire   +5 more sources

A clinically aligned experimental approach for quantitative characterization of patient-specific cardiovascular models

AIP Advances, 2020
Recent improvements in computational tools opened the possibility of patient-specific modeling to aid clinicians during diagnosis, treatment, and monitoring. One example is the modeling of blood flow for surgical planning, where modeling can help predict
Ana Paula Narata, Fernando Silva de Moura, Fréderic Patat, Alberto Marzo, Ignacio Larrabide, Jean-Marc Gregoire, Cecile Perrault, Charles A. Sennoga, Ayache Bouakaz   +8 more
doaj   +1 more source

Agent-based computational modeling of wounded epithelial cell monolayers [PDF]

, 2004
Computational modeling of biological systems, or ‘in silico biology’ is an emerging tool for understanding structure and order in biological tissues. Computational models of the behavior of epithelial cells in monolayer cell culture have been developed ...
Hill, G., Smallwood, R.H., Southgate, J., Walker, D.C., Wood, S.M.   +4 more
core   +1 more source

Hepatitis E Virus Cysteine Protease Has Papain Like Properties Validated by in silico Modeling and Cell-Free Inhibition Assays

Frontiers in Cellular and Infection Microbiology, 2020
Hepatitis E virus (HEV) has emerged as a global health concern during the last decade. In spite of a high mortality rate in pregnant women with fulminant hepatitis, no antiviral drugs or licensed vaccine is available in India.
S. Saraswat, M. Chaudhary, D. Sehgal
semanticscholar   +1 more source

Identification of Potential COX-2 Inhibitors for the Treatment of Inflammatory Diseases Using Molecular Modeling Approaches

Molecules, 2020
Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed in order to avoid the side effects of non-selective inhibitors of COX-1. Thus, the present study aims to identify new selective chemical entities for the
Pedro H. F. Araújo, Ryan S. Ramos, Jorddy N. da Cruz, Sebastião G. Silva, Elenilze F. B. Ferreira, Lúcio R. de Lima, Williams J. C. Macêdo, José M. Espejo-Román, Joaquín M. Campos, Cleydson B. R. Santos   +9 more
doaj   +1 more source

The in silico macrophage: toward a better understanding of inflammatory disease [PDF]

, 2011
Macrophages function as sentinel, cell-regulatory hubs capable of initiating, perpetuating and contributing to the resolution of an inflammatory response, following their activation from a resting state. Highly complex and varied gene expression programs
Ghazal, Peter, Kluth, David C, Robertson, Kevin, Watterson, Steven   +3 more
core   +3 more sources

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T., Breitling, Rainer, HASH(0x55aa09327868), Hodgson, D. A., Merlo, Maria E., Takano, Eriko, Wellington, E. M. H.   +6 more
core   +15 more sources

Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Showed Cardioprotection Effect in a Myocardial Ischemia (MI) Mouse Model

Proceedings, 2019
TLR4, a member of the toll-like receptors (TLRs) family, serves as a pattern recognition receptor in the innate immune response to different microbial pathogens. [...]
Lena Trifonov, Vadim Nudelman, Michael Zhenin, Guy Cohen, Krzysztof Jozwiak, Edward Korshin, Hanoch Senderowitz, Asher Shainberg, Edith Hochhauser, Arie Gruzman   +9 more
doaj   +1 more source