Results 31 to 40 of about 165,849 (202)
Critical Care Medicine, 2013 To familiarize clinicians with advances in computational disease modeling applied to trauma and sepsis.PubMed search and review of relevant medical literature.Definitions, key methods, and applications of computational modeling to trauma and sepsis are reviewed.Computational modeling of inflammation and organ dysfunction at the cellular, organ, whole ...
Yoram, Vodovotz, Timothy R, Billiar
openaire +2 more sources
Predicting Skin Permeability by means of Computational Approaches : Reliability and Caveats in Pharmaceutical Studies [PDF]
, 2019 © 2019 American Chemical Society.The skin is the main barrier between the internal body environment and the external one. The characteristics of this barrier and its properties are able to modify and affect drug delivery and chemical toxicity parameters.
Almerico, Anna Maria +5 more
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Journal of Genetic Engineering and Biotechnology, 2020 Background Lysyl oxidase is an extracellular regulatory enzyme with an imperative role in interlinking of collagen and elastin by oxidizing lysine residues. Lysyl oxidase has been implicated in incidence of mammary tumors in bitches.
Afnan Saleem, Shiveeli Rajput
doaj +1 more source
Building blocks of microphysiological system to model physiology and pathophysiology of human heart
Frontiers in Physiology, 2023 Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology.
Hanna Vuorenpää +17 more
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Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer. [PDF]
, 2015 We hypothesized that aberrations activating epidermal growth factor receptor (EGFR) via dimerization would be more sensitive to anti-dimerization agents (e.g., cetuximab).
Bazhenova, Lyudmila +6 more
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An in silico MS/MS library for automatic annotation of novel FAHFA lipids. [PDF]
, 2015 BackgroundA new lipid class named 'fatty acid esters of hydroxyl fatty acids' (FAHFA) was recently discovered in mammalian adipose tissue and in blood plasma and some FAHFAs were found to be associated with type 2 diabetes.
Fahrmann, Johannes F +5 more
core +2 more sources
In vitro and in silico Approaches to the Identification of New Compounds with Antibacterial Profile [PDF]
Journal of Systemics, Cybernetics and Informatics, 2013 The emergence of multidrug-resistant bacterial strains is a world problem that increases the need for new and more effective antimicrobials. On that purpose, derivatives of cyclic systems may serve as new leads for discovering new active molecules.
Carlos R. Rodrigues +9 more
doaj
Molecules, 2022 Aptamers, the nucleic acid analogs of antibodies, bind to their target molecules with remarkable specificity and sensitivity, making them promising diagnostic and therapeutic tools. The systematic evolution of ligands by exponential enrichment (SELEX) is
Ashraf M. Muhammad +5 more
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Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]
, 2009 We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon +54 more
core +3 more sources