Results 41 to 50 of about 165,849 (202)
In-silico modeling of granulomatous diseases [PDF]
Current Opinion in Pulmonary Medicine, 2016 The pathogenesis of genetically complex granulomatous diseases, such as sarcoidosis and latent tuberculosis, remains largely unknown. With the recent advent of more powerful research tools, such as genome-wide expression platforms, comes the challenge of making sense of the enormous data sets so generated. This manuscript will provide demonstrations of
openaire +2 more sources
Scientific ReportsCervical cancer stands as a prevalent gynaecologic malignancy affecting women globally, often linked to persistent human papillomavirus infection. Biomarkers associated with cervical cancer, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E, show ...
Anuraj Nayarisseri +12 more
doaj +1 more source
CDR1 Composition Can Affect Nanobody Recombinant Expression Yields
Biomolecules, 2021 The isolation of nanobodies from pre-immune libraries by means of biopanning is a straightforward process. Nevertheless, the recovered candidates often require optimization to improve some of their biophysical characteristics.
Marco Orlando +5 more
doaj +1 more source
Tubulin bond energies and microtubule biomechanics determined from nanoindentation in silico [PDF]
, 2015 Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral non-covalent bonds between the tubulin subunits.
Ataullakhanov, Fazly I. +7 more
core +1 more source
$In~Silico$ Electrical Modeling of Cell Aggregates [PDF]
IEEE Transactions on Magnetics, 2020 The paper deals with two different approaches to model cell aggregates submitted to an electric stimulation, namely the equivalent circuit approach and the theoretical homogenization. For each approach, the effective impedance of the cell aggregate is given, enabling a comparison between the different models.
Floriane Gidel +2 more
openaire +1 more source
Scientific ReportsPhthalic acid esters are pivotal plasticizers in various applications, including cosmetics, packaging materials, and medical devices. They have garnered significant attention from the scientific community due to their persistence in ecosystems.
Khushboo Sharma +2 more
doaj +1 more source
Developments in the tools and methodologies of synthetic biology. [PDF]
, 2014 Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices, or systems. However, biological systems are generally complex and unpredictable, and are therefore, intrinsically difficult to ...
Freemont, P +3 more
core +1 more source
Characterization and optimization of azo dyes degrading microbes isolated from textile effluent
Scientific ReportsAzo dyes are highly recalcitrant, persistent, and toxic compounds, extensively used in the textile industry. The untreated discharge of dye effluents from the textile industry poses severe environmental and health risks.
Arshiya Khan +2 more
doaj +1 more source
In silico modelling of hormone response elements [PDF]
BMC Bioinformatics, 2006 Abstract Background An important step in understanding the conditions that specify gene expression is the recognition of gene regulatory elements. Due to high diversity of different types of transcription factors and their DNA binding preferences, it is a challenging problem to establish an accurate model for ...
Stepanova, Maria +2 more
openaire +2 more sources
Dravet Variant SCN1AA1783V Impairs Interneuron Firing Predominantly by Altered Channel Activation
Frontiers in Cellular Neuroscience, 2021 Dravet syndrome (DS) is a developmental epileptic encephalopathy mainly caused by functional NaV1.1 haploinsufficiency in inhibitory interneurons. Recently, a new conditional mouse model expressing the recurrent human p.(Ala1783Val) missense variant has ...
Nikolas Layer +10 more
doaj +1 more source