Results 51 to 60 of about 236,648 (327)

Insights from the in silico structural, functional and phylogenetic characterization of canine lysyl oxidase protein

Journal of Genetic Engineering and Biotechnology, 2020
Background Lysyl oxidase is an extracellular regulatory enzyme with an imperative role in interlinking of collagen and elastin by oxidizing lysine residues. Lysyl oxidase has been implicated in incidence of mammary tumors in bitches.
Afnan Saleem, Shiveeli Rajput
doaj   +1 more source

Building blocks of microphysiological system to model physiology and pathophysiology of human heart

Frontiers in Physiology, 2023
Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology.
Hanna Vuorenpää, Hanna Vuorenpää, Hanna Vuorenpää, Miina Björninen, Miina Björninen, Miina Björninen, Hannu Välimäki, Hannu Välimäki, Antti Ahola, Antti Ahola, Mart Kroon, Mart Kroon, Laura Honkamäki, Laura Honkamäki, Jussi T. Koivumäki, Jussi T. Koivumäki, Mari Pekkanen-Mattila, Mari Pekkanen-Mattila   +17 more
doaj   +1 more source

Virtual In-Silico Modeling Guided Catheter Ablation Predicts Effective Linear Ablation Lesion Set for Longstanding Persistent Atrial Fibrillation: Multicenter Prospective Randomized Study

Frontiers in Physiology, 2017
Objective: Radiofrequency catheter ablation for persistent atrial fibrillation (PeAF) still has a substantial recurrence rate. This study aims to investigate whether an AF ablation lesion set chosen using in-silico ablation (V-ABL) is clinically feasible
J. Shim, M. Hwang, Jun-Seop Song, B. Lim, Tae‐Hoon Kim, B. Joung, Sung-Hwan Kim, Y. Oh, G. Nam, Y. On, Seil Oh, Young-Hoon Kim, H. Pak   +12 more
semanticscholar   +1 more source

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? [PDF]

, 2006
The organization and mining of malaria genomic and post-genomic data is highly motivated by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data
Bastien, Olivier, Birkholtz, Lyn-Marie, Breton, Vincent, Grando, Delphine, Hofmann-Apitius, Martin, Jacq, Nicolas, Joubert, Fourie, Kasam, Vinod, Louw, Abraham I, Maréchal, Eric, Ortet, Philippe, Roy, Sylvaine, Saïdani, Nadia, Wells, Gordon, Zimmermann, Marc   +14 more
core   +5 more sources

BCNNM: A Framework for in silico Neural Tissue Development Modeling

Frontiers in Computational Neuroscience, 2021
Cerebral (“brain”) organoids are high-fidelity in vitro cellular models of the developing brain, which makes them one of the go-to methods to study isolated processes of tissue organization and its electrophysiological properties, allowing to collect ...
Dmitrii V. Bozhko, Georgii K. Galumov, Aleksandr I. Polovian, Sofiia Kolchanova, Vladislav O. Myrov, Viktor A. Stelmakh, H. Schiöth   +6 more
semanticscholar   +1 more source

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping and in silico modeling to identify new therapeutics

Frontiers in Cellular and Infection Microbiology
Sepsis is a global health concern accounting for more than 1 in 5 deaths worldwide. Sepsis is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.
Dan Liu, J. Langston, B. Prabhakarpandian, Mohammad F. Kiani, Laurie E. Kilpatrick   +4 more
semanticscholar   +1 more source

Discovering Novel Alternaria solani Succinate Dehydrogenase Inhibitors by in Silico Modeling and Virtual Screening Strategies to Combat Early Blight

Frontiers in Chemistry, 2017
Alternaria blight is an important foliage disease caused by Alternaria solani. The enzyme Succinate dehydrogenase (SDH) is a potential drug target because of its role in tricarboxylic acid cycle.
S. Iftikhar, A. A. Shahid, S. Halim, P. J. Wolters, V. Vleeshouwers, Ajmal Khan, A. Al‐Harrasi, Shahbaz Ahmad   +7 more
semanticscholar   +1 more source

Novel Design of RNA Aptamers as Cancer Inhibitors and Diagnosis Targeting the Tyrosine Kinase Domain of the NT-3 Growth Factor Receptor Using a Computational Sequence-Based Approach

Molecules, 2022
Aptamers, the nucleic acid analogs of antibodies, bind to their target molecules with remarkable specificity and sensitivity, making them promising diagnostic and therapeutic tools. The systematic evolution of ligands by exponential enrichment (SELEX) is
Ashraf M. Muhammad, Ali Zari, Nouf H. Alsubhi, Maryam H. Al-Zahrani, Rana Abdullah Alghamdi, Mai M. Labib   +5 more
doaj   +1 more source

Improved Accuracy for Modeling PROTAC-Mediated Ternary Complex Formation and Targeted Protein Degradation via New In Silico Methodologies.

Journal of Chemical Information and Modeling, 2020
Extending upon our previous publication (Drummond, M., Williams, C., In Silico Modeling of PROTAC-mediated Ternary Complexes: Validation and Application, J. Chem. Inf.
M. Drummond, Andrew Henry, Huifang Li, C. Williams   +3 more
semanticscholar   +1 more source