Results 1 to 10 of about 26,329 (273)

Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method [PDF]

Brazilian Journal of Medical and Biological Research, 2017
This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study
Y.-H. Wang, X.-M. Ke, C.-H. Zhang, R.-P. Yang   +3 more
doaj   +6 more sources

Application of Rat In Situ Single-pass Intestinal Perfusion in the Evaluation of Presystemic Extraction of Indinavir Under Different Perfusion Rates [PDF]

Journal of the Formosan Medical Association, 2008
First-pass effect has been an important concern for oral pharmaceuticals. An in vivo system was developed for measuring different concentrations of pharmaceuticals in the portal vein and hepatic vein (via the inferior vena cava) for delineating ...
Yunn-Fang Ho, Ming-Yen Lai, Hsiu-Ying Yu, Da-Kong Huang, Wei-Cherng Hsueh, Tung-Hu Tsai, Chia-Chun Lin   +6 more
doaj   +5 more sources

Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique [PDF]

Pharmaceutics, 2021
Oleacein (OLEA) is one of the most important phenolic compounds in extra virgin olive oil in terms of concentration and health-promoting properties, yet there are insufficient data on its absorption and metabolism.
Anallely López-Yerena, Maria Pérez, Anna Vallverdú-Queralt, Eleftherios Miliarakis, Rosa M. Lamuela-Raventós, Elvira Escribano-Ferrer   +5 more
doaj   +4 more sources

Glyceroniosomes for enhanced intestinal absorption of hydrochlorothiazide and lisinopril in their fixed dose combination [PDF]

Scientific Reports
The objective was to investigate the effect of co-administration of hydrochlorothiazide and lisinopril as fixed dose combination on their intestinal absorption. The scope was extended to enhance intestinal absorption of both drugs.
Aya R. Elbasuony, Abdelaziz E. Abdelaziz, Eman A. Mazyed, Gamal M. El Maghraby   +3 more
doaj   +2 more sources

Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation [PDF]

Nature Communications
Trillions of intestinal microbiota are essential to the permeability of orally administered drugs. However, identifying microbial-drug interactions remains challenging due to the highly variable composition of intestinal flora among individuals.
Yu-Hang Zhang, Chen-Shu Dai, Ya-Jie Wang, Wen-Yu Wang, Tian-Tian Qi, Man-Cheng Xia, Gan Zhou, Yi-Min Cui   +7 more
doaj   +2 more sources

Bilosomes and Niosomes for Enhanced Intestinal Absorption and In Vivo Efficacy of Cytarabine in Treatment of Acute Myeloid Leukemia [PDF]

Pharmaceuticals
Cytarabine (CTR) is a hydrophilic anticancer drug used to treat leukemia. It suffers from poor permeability and intestinal metabolism, diminishing its oral bioavailability.
Abdelrahman R. Said, Mona F. Arafa, Walaa A. El-Dakroury, Sultan Alshehri, Gamal M. El Maghraby   +4 more
doaj   +2 more sources

Estimation of Catha edulis (Vahl) Forssk. ex Endl. – antidiabetic drug interactions by using closed-loop Doluisio’s method [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2023
Context: Catha edulis (khat) is a prevalent plant in Yemen and other African regions. In Yemen and other countries, most people chew this plant, which may change the pharmacokinetics of many drugs, such as anti-diabetics (glibenclamide and metformin).
Ahmed M. Al-Ghani, Mohammed A. Al-Khawlani, Anes A.M. Thabet   +2 more
doaj   +1 more source

Optimization of a Self-microemulsifying Drug Delivery System for Oral Administration of the Lipophilic Drug, Resveratrol: Enhanced Intestinal Permeability in Rat [PDF]

Advanced Pharmaceutical Bulletin, 2023
Purpose: This study aimed to formulate Resveratrol, a practically water-insoluble antioxidant in a self-microemulsifying drug delivery system (SMEDDS) to improve the solubility, release rate, and intestinal permeability of the drug. Methods: The suitable
Shahla Mirzaeei, Negar Tahmasebi, Ziba Islambulchilar   +2 more
doaj   +1 more source

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

Pharmaceutics, 2022
The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent anti-ischemic and neuroprotective effects. In this study, the pKa and the pH-solubility profile were
Claudia Miranda, Alejandro Ruiz-Picazo, Paula Pomares, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Alex Avdeef, Miguel-Ángel Cabrera-Pérez   +7 more
doaj   +1 more source

Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies

Pharmaceutics, 2022
The anticancer agent abiraterone suffers from an extensive positive food effect after oral intake of the prodrug abiraterone acetate (Zytiga). The underlying processes determining postprandial abiraterone absorption were investigated in this study.
Marlies Braeckmans, Patrick Augustijns, Raf Mols, Cécile Servais, Joachim Brouwers   +4 more
doaj   +1 more source