Oleacein Intestinal Permeation and Metabolism in Rats Using an In Situ Perfusion Technique [PDF]
Pharmaceutics, 2021 Oleacein (OLEA) is one of the most important phenolic compounds in extra virgin olive oil in terms of concentration and health-promoting properties, yet there are insufficient data on its absorption and metabolism.
Anallely López-Yerena +5 more
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Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method [PDF]
Brazilian Journal of Medical and Biological Research, 2017 This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study
Y.-H. Wang +3 more
doaj +6 more sources
Application of Rat In Situ Single-pass Intestinal Perfusion in the Evaluation of Presystemic Extraction of Indinavir Under Different Perfusion Rates [PDF]
Journal of the Formosan Medical Association, 2008 First-pass effect has been an important concern for oral pharmaceuticals. An in vivo system was developed for measuring different concentrations of pharmaceuticals in the portal vein and hepatic vein (via the inferior vena cava) for delineating ...
Yunn-Fang Ho +6 more
doaj +6 more sources
Effect of berbamine hydrochloride on the absorption of berberine hydrochloride in an in situ single-pass intestinal perfusion system in rats [PDF]
, 2022 Purpose: To investigate the intestinal absorption characteristics of berberine hydrochloride (BBH) under different perfusion conditions in rats.Methods: Based on the in situ single-pass intestinal perfusion model of rats, HPLC was used to determine the ...
Xi Tang +7 more
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In situ perfusion in rodents to explore intestinal drug absorption: Challenges and opportunities
International Journal of Pharmaceutics, 2014 The in situ intestinal perfusion technique in rodents is a very important absorption model, not only because of its predictive value, but it is also very suitable to unravel the mechanisms underlying intestinal drug absorption. This literature overview covers a number of specific applications for which the in situ intestinal perfusion set-up can be ...
Jef Stappaerts +3 more
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Intestinal absorption of forsythoside A in in situ single-pass intestinal perfusion and in vitro Caco-2 cell models [PDF]
Acta Pharmacologica Sinica, 2012 To investigate the mechanisms underlying the intestinal absorption of the major bioactive component forsythoside A (FTA) extracted from Forsythiae fructus.An in vitro Caco-2 cell model and a single-pass intestinal perfusion in situ model in SD rats were used.In the in vitro Caco-2 cell model, the mean apparent permeability value (P(app)-value) was 4.15×
Wei Zhou +6 more
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The assessment of absorption of periplocin in situ via intestinal perfusion of rats by HPLC [PDF]
Biomedical Chromatography, 2007 AbstractPeriplocin is an important compound of Cortex Periplocae, which shows poor absorption when administered orally. The effective intestinal permeability of periplocin was investigated using single‐pass intestinal perfusion technique in male Wistar rats. SPIP was performed in rat jejunum.
Yue‐Sheng Xie +4 more
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Mechanisms of gemcitabine oral absorption as determined by in situ intestinal perfusions in mice
Biochemical Pharmacology, 2019 Gemcitabine is a widely used chemotherapeutic drug that is administered via intravenous infusion due to a low oral bioavailability of only 10%. This low oral bioavailability is believed to be the result of gemcitabine's low intestinal permeability and oral absorption, followed by significant presystemic metabolism.
Brian R. Thompson +2 more
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The Absorption Characteristics of Nonvolatile Components in a Water Extraction From Amomi fructus as Determined by In Situ Single-Pass Intestinal Perfusion and High-Performance Liquid Chromatography [PDF]
Frontiers in Pharmacology, 2020 BackgroundAmomi fructus is a famous traditional Chinese medicine (TCM) that can exert beneficial effects during the treatment of gastrointestinal diseases and is used widely in China and other countries in Southeast Asia.
Yuebao Yao +7 more
doaj +2 more sources
Journal of Pharmacy & Pharmaceutical Sciences, 2011 PURPOSE: To determine experimentally the intestinal permeability of the anticancer prodrug irinotecan, and to quantify the amount of its cytotoxic metabolite SN-38 that is intestinally excreted (exsorped) as a predictor of intestinal toxicity, and to ...
Abdullah Khalil Rabba +4 more
doaj +3 more sources