Journal of Pharmaceutical and Biopharmaceutical Research, 2019 Garcinia Glycosides is a candidate drug obtained by structural modification of Gambogic Acid (GA), which was acquired through High Throughput Screening(HTS). As Garcinia Glycosides is an effective but insoluble anti-tumor drug, the aim of this study was to obtain a solid dispersion form Garcinia Glycosides by using solvent-melt method so that improve ...
Shengnan Li, Ye Chen
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Indian Journal of Pharmaceutical Sciences, 2010 Previously, permeability and site of intestinal absorption of propranolol have been reported using the Ussing chamber. In the present study, the utility of Single-Pass Intestinal Perfusion to study permeability and site of intestinal absorption of propranolol was evaluated in rats. Drug permeability in different regions of rat intestine viz.
Anagha Damre +6 more
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The assessment of absorption of periplocinin situvia intestinal perfusion of rats by HPLC [PDF]
Biomedical Chromatography, 2007 AbstractPeriplocin is an important compound of Cortex Periplocae, which shows poor absorption when administered orally. The effective intestinal permeability of periplocin was investigated using single‐pass intestinal perfusion technique in male Wistar rats. SPIP was performed in rat jejunum.
Yue‐Sheng Xie +4 more
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Glyceroniosomes for enhanced intestinal absorption of hydrochlorothiazide and lisinopril in their fixed dose combination [PDF]
Scientific ReportsThe objective was to investigate the effect of co-administration of hydrochlorothiazide and lisinopril as fixed dose combination on their intestinal absorption. The scope was extended to enhance intestinal absorption of both drugs.
Aya R. Elbasuony +3 more
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Intestinal Water and Solute Absorption Studies: Comparison of in Situ Perfusion with Chronic Isolated Loops in Rats [PDF]
Pharmaceutical Research, 1992 The effects of lumenal glucose on jejunal water transport and the influence of glucose-induced water absorption on solute uptake from single-pass perfusions are compared in anesthetized rats in situ and isolated chronic loops in unanesthetized rats in vivo.
Hsiao‐Hwa Lu +3 more
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Repaglinide-loaded nanostructured lipid carriers with different particle sizes for improving oral absorption: preparation, characterization, pharmacokinetics, and in situ intestinal perfusion [PDF]
Drug Deliv, 2019 Lei Wu +4 more
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Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation [PDF]
Nature CommunicationsTrillions of intestinal microbiota are essential to the permeability of orally administered drugs. However, identifying microbial-drug interactions remains challenging due to the highly variable composition of intestinal flora among individuals.
Yu-Hang Zhang +7 more
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Bilosomes and Niosomes for Enhanced Intestinal Absorption and In Vivo Efficacy of Cytarabine in Treatment of Acute Myeloid Leukemia [PDF]
PharmaceuticalsCytarabine (CTR) is a hydrophilic anticancer drug used to treat leukemia. It suffers from poor permeability and intestinal metabolism, diminishing its oral bioavailability.
Abdelrahman R. Said +4 more
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Estimation of Catha edulis (Vahl) Forssk. ex Endl. – antidiabetic drug interactions by using closed-loop Doluisio’s method [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Catha edulis (khat) is a prevalent plant in Yemen and other African regions. In Yemen and other countries, most people chew this plant, which may change the pharmacokinetics of many drugs, such as anti-diabetics (glibenclamide and metformin).
Ahmed M. Al-Ghani +2 more
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