Repaglinide-loaded nanostructured lipid carriers with different particle sizes for improving oral absorption: preparation, characterization, pharmacokinetics, and in situ intestinal perfusion. [PDF]
Drug Deliv, 2020 Wu L, Zhao L, Su X, Zhang P, Ling G.
europepmc +3 more sources
Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats [PDF]
Pharmaceutics, 2020 An increased interest in colonic drug delivery has led to a higher focus on the design of delivery devices targeting this part of the gastrointestinal tract. Microcontainers have previously facilitated an increase in oral bioavailability of drugs.
Juliane Fjelrad Christfort +7 more
doaj +3 more sources
Assessment of absorption of four lignan constituents of JingNing particles in rat gut using in situ single-pass intestinal perfusion [PDF]
, 2017 Purpose: To study small intestinal absorption of schisadrol A, schisandrol B, schizandrin A and schisandrin B in JingNing particles using in situ single-pass intestinal perfusion (SPIP).Methods: Absorption rate constant (Ka) and apparent permeability ...
Cao, Sali +10 more
core +3 more sources
In situ perfusion in rodents to explore intestinal drug absorption: Challenges and opportunities
International Journal of Pharmaceutics, 2014 The in situ intestinal perfusion technique in rodents is a very important absorption model, not only because of its predictive value, but it is also very suitable to unravel the mechanisms underlying intestinal drug absorption. This literature overview covers a number of specific applications for which the in situ intestinal perfusion set-up can be ...
Jef Stappaerts +3 more
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Intestinal absorption of forsythoside A in in situ single-pass intestinal perfusion and in vitro Caco-2 cell models [PDF]
Acta Pharmacologica Sinica, 2012 To investigate the mechanisms underlying the intestinal absorption of the major bioactive component forsythoside A (FTA) extracted from Forsythiae fructus.An in vitro Caco-2 cell model and a single-pass intestinal perfusion in situ model in SD rats were used.In the in vitro Caco-2 cell model, the mean apparent permeability value (P(app)-value) was 4.15×
Wei Zhou +6 more
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The assessment of absorption of periplocin in situ via intestinal perfusion of rats by HPLC [PDF]
Biomedical Chromatography, 2007 AbstractPeriplocin is an important compound of Cortex Periplocae, which shows poor absorption when administered orally. The effective intestinal permeability of periplocin was investigated using single‐pass intestinal perfusion technique in male Wistar rats. SPIP was performed in rat jejunum.
Yue‐Sheng Xie +4 more
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Mechanisms of gemcitabine oral absorption as determined by in situ intestinal perfusions in mice
Biochemical Pharmacology, 2019 Gemcitabine is a widely used chemotherapeutic drug that is administered via intravenous infusion due to a low oral bioavailability of only 10%. This low oral bioavailability is believed to be the result of gemcitabine's low intestinal permeability and oral absorption, followed by significant presystemic metabolism.
Brian R. Thompson +2 more
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Estimation of Catha edulis (Vahl) Forssk. ex Endl. – antidiabetic drug interactions by using closed-loop Doluisio’s method [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Catha edulis (khat) is a prevalent plant in Yemen and other African regions. In Yemen and other countries, most people chew this plant, which may change the pharmacokinetics of many drugs, such as anti-diabetics (glibenclamide and metformin).
Ahmed M. Al-Ghani +2 more
doaj +1 more source
Journal of Pharmaceutical and Biopharmaceutical Research, 2019 Garcinia Glycosides is a candidate drug obtained by structural modification of Gambogic Acid (GA), which was acquired through High Throughput Screening(HTS). As Garcinia Glycosides is an effective but insoluble anti-tumor drug, the aim of this study was to obtain a solid dispersion form Garcinia Glycosides by using solvent-melt method so that improve ...
Shengnan Li, Ye Chen
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INTESTINAL SINGLE-PASS IN SITU PERFUSION TECHNIQUE IN RAT: THE INFLUENCE OF L-CARNITINE ON ABSORPTION OF 7-METHOXYTACRINE [PDF]
Biomedical Papers, 2005 7-Methoxytacrine (7-MEOTA) is an acetylcholine-esterase inhibitor that is potentially useful in the therapy of some neurodegenerative disorders. L-carnitine (CRT) is a naturally occuring compound that is known to increase penetration of some compounds through biological barriers.
Martin Kuneš +5 more
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