Results 21 to 30 of about 26,404 (336)

Optimization of a Self-microemulsifying Drug Delivery System for Oral Administration of the Lipophilic Drug, Resveratrol: Enhanced Intestinal Permeability in Rat [PDF]

Advanced Pharmaceutical Bulletin, 2023
Purpose: This study aimed to formulate Resveratrol, a practically water-insoluble antioxidant in a self-microemulsifying drug delivery system (SMEDDS) to improve the solubility, release rate, and intestinal permeability of the drug. Methods: The suitable
Shahla Mirzaeei, Negar Tahmasebi, Ziba Islambulchilar   +2 more
doaj   +1 more source

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

Pharmaceutics, 2022
The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent anti-ischemic and neuroprotective effects. In this study, the pKa and the pH-solubility profile were
Claudia Miranda, Alejandro Ruiz-Picazo, Paula Pomares, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Alex Avdeef, Miguel-Ángel Cabrera-Pérez   +7 more
doaj   +1 more source

Investigating the Mechanisms behind the Positive Food Effect of Abiraterone Acetate: In Vitro and Rat In Situ Studies

Pharmaceutics, 2022
The anticancer agent abiraterone suffers from an extensive positive food effect after oral intake of the prodrug abiraterone acetate (Zytiga). The underlying processes determining postprandial abiraterone absorption were investigated in this study.
Marlies Braeckmans, Patrick Augustijns, Raf Mols, Cécile Servais, Joachim Brouwers   +4 more
doaj   +1 more source

Synthesis and Evaluation of PEG-PR for Water Flux Correction in an In Situ Rat Perfusion Model

Molecules, 2020
Phenol red (PR) is a widely used marker for water flux correction in studies of in situ perfusion, in which intestinal absorption usually leads to the underestimation of results. In this paper, we propose a novel marker polyethylene glycol (PEG)-PR (i.e.,
Guo Chen, Xingqi Min, Qunqun Zhang, Zhiqiang Zhang, Meiqiang Wen, Jun Yang, Meijuan Zou, Wei Sun, Gang Cheng   +8 more
doaj   +1 more source

Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Polyphenols, a group of complex naturally occurring compounds, are widely distributed throughout the plant kingdom and are therefore readily consumed by humans.
Zenghui Teng, Chengjun Yuan, Feng Zhang, Menglei Huan, Weidong Cao, Kangchu Li, Jingyue Yang, Dayong Cao, Siyuan Zhou, Qibing Mei   +9 more
doaj   +1 more source

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]

, 2003
The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William, Dufès, Christine, Gaillard, Afsaneh, Gaillard, Frédéric, Muller, Jean-Marc, Olivier, Jean-Christophe   +5 more
core   +3 more sources

Antihyperglycemic potential of the Lavandula stoechas aqueous extract via inhibition of digestive enzymes and reduction of intestinal glucose absorption

Journal of Ayurveda and Integrative Medicine, 2023
Background: Diabetes mellitus is a widespread metabolic disorder affecting global populations. Lavandula stoechas from Moroccan traditional medicine is used for its potential anti-diabetic effects.
Amal Elrherabi, Mohamed Bouhrim, Rhizlan Abdnim, Ali Berraaouan, Abderrahim Ziyyat, Hassane Mekhfi, Abdelkhaleq Legssyer, Mohamed Bnouham   +7 more
doaj   +1 more source

Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat

Molecules, 2014
Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the
Yan Huo, Yuxing Huang, Xiangmei Hou, Lifeng Han, Lei Wang, Erwei Liu, Xiumei Gao   +6 more
doaj   +1 more source

Effect of ischemia on the canine large bowel: A comparison with the small intestine [PDF]

, 1996
Mucosal injury caused by ischemia and reperfusion has been well documented with the small intestine, but little is known about the colon. In the present study, the effect of warm and cold ischemia on the canine colon was studied and compared to that on ...
Ikoma, A, Nakamura, K, Starzl, TE, Takeyoshi, I, Todo, S, Zhang, S, Zhu, Y   +6 more
core   +1 more source

Etretinate absorption in the in situ perfused intestinal lumen: Preliminary studies in the rat [PDF]

Biopharmaceutics & Drug Disposition, 1991
AbstractThe absorption characteristics of etretinate were examined in the Sprague‐Dawley rat with the use of the in situ intestinal lumen perfusion model. Intestinal segments of 15–50cm were cannulated and perfused with etretinate solutions of 178–1405 μgml−1 in a single‐pass manner at flow rates of 0·15–0·96 ml min−1.
C L, Zimmerman, K E, Johnson
openaire   +2 more sources