Intestinal water and solute absorption studies: comparison of in situ perfusion with chronic isolated loops in rats. [PDF]
Pharmaceutical research, 1992 The effects of lumenal glucose on jejunal water transport and the influence of glucose-induced water absorption on solute uptake from single-pass perfusions are compared in anesthetized rats in situ and isolated chronic loops in unanesthetized rats in vivo.
Hsiao‐Hwa Lu +3 more
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Chemical and Pharmaceutical Bulletin, 1981 The effect of carbachol on the absorptions of caffeine, aminopyrine and salicylic acid in the rat small intestine was studied, using an in situ recirculating perfusion method. Carbachol, either added to the perfusate or injected intravenously, remarkably reduced drug absorption.
Osami Tsuzuki +3 more
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Bilosomes and Niosomes for Enhanced Intestinal Absorption and In Vivo Efficacy of Cytarabine in Treatment of Acute Myeloid Leukemia [PDF]
PharmaceuticalsCytarabine (CTR) is a hydrophilic anticancer drug used to treat leukemia. It suffers from poor permeability and intestinal metabolism, diminishing its oral bioavailability.
Abdelrahman R. Said +4 more
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Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models [PDF]
Biopharmaceutics & Drug Disposition, 2015 AbstractIn recent years prodrug strategy has been used extensively to improve the pharmacokinetic properties of compounds exhibiting poor bioavailability. Mechanistic understanding of the absorption and the role of intestine and liver in the activation of oral prodrugs is crucial.
Vinay K. Holenarsipur +11 more
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Preparation, optimization, and characterization of genistein-ginseng long-acting polymeric gel as a breast cancer treatment alternative [PDF]
Discover OncologyTo address the prevalent genistein (GST) metabolism and inadequate intestinal absorption, an oral long-acting and gastric in-situ gelling gel was designed to encapsulate and localize the intestinal release of the loaded genistein-ginseng (GST-GNS) solid ...
Samaa Abdullah +6 more
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Towards Effective Antiviral Oral Therapy: Development of a Novel Self-Double Emulsifying Drug Delivery System for Improved Zanamivir Intestinal Permeability [PDF]
Pharmaceutics, 2023 Self-double emulsifying drug delivery systems have the potential to enhance the intestinal permeability of drugs classified under the Biopharmaceutics Classification System (BCS) class III.
Sapir Ifrah, Arik Dahan, Nir Debotton
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Repaglinide-loaded nanostructured lipid carriers with different particle sizes for improving oral absorption: preparation, characterization, pharmacokinetics, and in situ intestinal perfusion [PDF]
Drug Deliv, 2019 Lei Wu +4 more
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Estimation of Catha edulis (Vahl) Forssk. ex Endl. – antidiabetic drug interactions by using closed-loop Doluisio’s method [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Catha edulis (khat) is a prevalent plant in Yemen and other African regions. In Yemen and other countries, most people chew this plant, which may change the pharmacokinetics of many drugs, such as anti-diabetics (glibenclamide and metformin).
Ahmed M. Al-Ghani +2 more
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Optimization of a Self-microemulsifying Drug Delivery System for Oral Administration of the Lipophilic Drug, Resveratrol: Enhanced Intestinal Permeability in Rat [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: This study aimed to formulate Resveratrol, a practically water-insoluble antioxidant in a self-microemulsifying drug delivery system (SMEDDS) to improve the solubility, release rate, and intestinal permeability of the drug. Methods: The suitable
Shahla Mirzaeei +2 more
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