Results 51 to 60 of about 120,404,711 (181)

Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo

Journal of Traditional Chinese Medical Sciences, 2021
Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption.
Yang Liu, Jing Sun, Linying Zhong, Yu Li, A Na Er, Tong Li, Le Yang, Ling Dong   +7 more
doaj   +1 more source

Infused Oyster Mushroom (Pleurotus ostreatus) Inhibits Glucose Absorption through Intestinal Mucosal Membrane in Wistar Rats

International Journal of Integrated Health Sciences, 2018
Objective: To observe the effects of infused oyster mushroom (latin name: Pleurotus ostreatus) on glucose absorption through the intestinal mucosal membrane in Wistar rats. Methods: This study used experimental design. Subjects of this study were six
Eko Fuji Ariyanto, Muhammad Nurhalim Shahib, Abdullah Firmansah Wargahadibrata   +2 more
doaj   +1 more source

Intestinal absorption mechanisms of araloside A in situ single-pass intestinal perfusion and in vitro Caco-2 cell model

Biomedicine & Pharmacotherapy, 2018
Araloside A is a triterpenoid saponin,which exhibits a broad spectrum of pharmacological activities, such as stimulating fibrinolysis, preventing coagulant, inhibiting renin, and decreasing blood pressure. Our previous report found that the compound exhibits a poor absolute bioavailability.
Hui, Yang, Bingtao, Zhai, Yu, Fan, Jing, Wang, Jing, Sun, Yajun, Shi, Dongyan, Guo   +6 more
openaire   +2 more sources

A study of intestinal absorption of bicyclol in rats: active efflux transport and metabolism as causes of its poor bioavailability

Journal of Pharmacy & Pharmaceutical Sciences, 2008
Purpose.To determine the possible mechanism of poor bioavailability of bicyclol, and clarify the respective contribution of P- glycoprotein (P-gp) and Cytochrome 3A (CYP3A). Methods. Rat in situ single-pass intestinal perfusion and Caco-2 cell monolayer
Wei Tan, Hui Chen, Jinping Hu, Yan Li
doaj   +1 more source

Experimental studies on coronary perfusion with pump-oxygenator [PDF]

, 1959
1. Methods of retrograde coronary perfusion and direct coronary artery perfusion in combination with a bubble oxygenator were investigated in dogs. 2.
Hayashi, Naomi
core   +1 more source

Bovine colostrum increases pore-forming claudin-2 protein expression but paradoxically not ion permeability possibly by a change of the intestinal cytokine milieu. [PDF]

PLoS ONE, 2013
An impaired intestinal barrier function is involved in the pathogenesis of inflammatory bowel disease (IBD). Several nutritional factors are supposed to be effective in IBD treatment but scientific data about the effects on the intestinal integrity ...
Peggy Bodammer, Claus Kerkhoff, Claudia Maletzki, Georg Lamprecht   +3 more
doaj   +1 more source

Intestinal Water and Solute Absorption Studies: Comparison of in Situ Perfusion with Chronic Isolated Loops in Rats [PDF]

Pharmaceutical Research, 1992
The effects of lumenal glucose on jejunal water transport and the influence of glucose-induced water absorption on solute uptake from single-pass perfusions are compared in anesthetized rats in situ and isolated chronic loops in unanesthetized rats in vivo.
Fleisher, David, Lu, Hsiao-Hwa, Tukker, Josef J., Thomas, James D.   +3 more
openaire   +3 more sources

Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat

, 2017
The flower bud of Daphne genkwa (Genkwa Flos) is a commonly used herbal medicine in Asian countries. Luteolin and apigenin are two recognized active flavonoids in Genkwa Flos. The aim of this study was to investigate the intestinal absorption mechanisms
Xin He, Cui-Ping Jiang, Zi-Jing Song, Chun-Feng Zhang   +3 more
core   +1 more source

Absorption Characteristics of U-63,287 as Evaluated by In Situ Rat Gut Perfusion

, 1984
vi, 64 p.This project characterizes the absorption in the rat's Intestines of U-63,287, an oral antidiabetic drug. The method used to study U-63,287's absorption is a modification of an in situ intestinal perfusion technique developed by ...
Bangs, Mark E.
core   +2 more sources

Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin

Acta Pharmaceutica Sinica B, 2014
The aim of this study was to develop a formulation to improve the oral absorption of baicalin (BA) by combining a phospholipid complex (PC) and self-emulsifying microemulsion drug delivery system (SMEDDS), termed BA–PC–SMEDDS.
Huiyi Wu, Xiaoying Long, Fei Yuan, Li Chen, Sujing Pan, Yunjun Liu, Yoshiko Stowell, Xiaoling Li   +7 more
doaj   +1 more source